InAADR

Protein Information

Protein Name: delta-Type opioid receptor (P41143)
Gene Name: OPRD1
Description:
PDB ID: 1OZC
Protein Family: PF00001, PS00237
Protein Category: Membrane Receptors

This panel provides drug-protein interaction and their ADRs along with references

Interacting Drugs Toxicity Mechanism Reference
Clonidine Side Effects Of Clozapine Effects of clozapine on the delta- and kappa-opioid receptors and the G-protein-activated K+ (GIRK) channel expressed in Xenopus oocytes@which suggests efficacy and side effects of clozapine under clinical conditions may be partly due to activation of the delta-opioid receptor and blockade of the GIRK channel [ ADR Type 1 ] Effects of clozapine on the delta- and kappa-opioid receptors and the G-protein-activated K+ (GIRK) channel expressed in Xenopus oocytes
Pilocarpine Seizures Changes in hippocampal circuitry after pilocarpine-induced seizures@which caused a decrease in mu- and delta-opioid receptor immunoreactive (MOR-IR and DOR-IR@ respectively) neurons in the hilus and MOR-IR neurons in the granule cell layer. [ ADR Type 5 ] Changes in hippocampal circuitry after pilocarpine-induced seizures as revealed by opioid receptor distribution and activation

This panel provides information on drug category

Toxicity Source
Biliary Colic Large-scale prediction and testing of drug activity on side-effect targets
Bladder Disorder Large-scale prediction and testing of drug activity on side-effect targets
Bradycardia Large-scale prediction and testing of drug activity on side-effect targets
Cerebrovascular Disorder Large-scale prediction and testing of drug activity on side-effect targets
Constipation Large-scale prediction and testing of drug activity on side-effect targets
Death Large-scale prediction and testing of drug activity on side-effect targets
Dependence Large-scale prediction and testing of drug activity on side-effect targets
Dermatitis Contact Large-scale prediction and testing of drug activity on side-effect targets
Drug Tolerance Large-scale prediction and testing of drug activity on side-effect targets
Dysuria Large-scale prediction and testing of drug activity on side-effect targets
Euphoric Mood Large-scale prediction and testing of drug activity on side-effect targets
Hyperhidrosis Large-scale prediction and testing of drug activity on side-effect targets
Hypothermia Large-scale prediction and testing of drug activity on side-effect targets
Injection Site Irritation Large-scale prediction and testing of drug activity on side-effect targets
Injection Site Pain Large-scale prediction and testing of drug activity on side-effect targets
Intracranial Pressure Increased Large-scale prediction and testing of drug activity on side-effect targets
Mental Disorder Large-scale prediction and testing of drug activity on side-effect targets
Miosis Large-scale prediction and testing of drug activity on side-effect targets
Mood Altered Large-scale prediction and testing of drug activity on side-effect targets
Muscle Spasms Large-scale prediction and testing of drug activity on side-effect targets
Oliguria Large-scale prediction and testing of drug activity on side-effect targets
Orthostatic Hypotension Large-scale prediction and testing of drug activity on side-effect targets
Pruritus Large-scale prediction and testing of drug activity on side-effect targets
Respiratory Depression Large-scale prediction and testing of drug activity on side-effect targets
Restlessness Large-scale prediction and testing of drug activity on side-effect targets
Shock Large-scale prediction and testing of drug activity on side-effect targets
Somnolence Large-scale prediction and testing of drug activity on side-effect targets
Ureteral Spasm Large-scale prediction and testing of drug activity on side-effect targets
Urticaria Large-scale prediction and testing of drug activity on side-effect targets
Withdrawal Syndrome Large-scale prediction and testing of drug activity on side-effect targets

InAADR: Drug-Protein-ADRs database