| Protein Name: | Urokinase plasminogen activator surface receptor (Q03405) |
|---|---|
| Gene Name: | PLAUR |
| Description: | Urokinase plasminogen activator surface receptor precursor (uPAR) (U- PAR) (Monocyte activation antigen Mo3) (CD87 antigen) |
| PDB ID: | 1YWH |
| Protein Family: | |
| Protein Category: | Membrane Receptors |
This panel provides drug-protein interaction and their ADRs along with references
| Interacting Drugs | Toxicity | Mechanism | Reference |
|---|---|---|---|
| urokinase-type Plasminogen activator (pro-u-PA) | Cell Cytoskeleton Reorganization | induced a chemotactic response in rat smooth muscle cells (RSMC) through binding to the membrane receptor of urokinase (u-PA receptor [u-PAR]);Pro-u-PA induced a decrease in stress fiber content@ membrane ruffling@ actin ring formation@ and disruption leading to the characteristic elongated cell shape of motile cells with an actin semi-ring located close to the leading edge of cells@ leading to cell cytoskeleton reorganization and cell migration. [ ADR Type 1 ] | Src-dependence and pertussis-toxin sensitivity of urokinase receptor-dependent chemotaxis and cytoskeleton reorganization in rat smooth muscle cells |
This panel provides information on drug category
| Toxicity | Source |
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