| Protein Name: | UDP-glucuronosyltransferase (P22309) |
|---|---|
| Gene Name: | UGT1A1 |
| Description: | UDP-glucuronosyltransferase 1-1 precursor (EC 2 4 1 17) (UDP- glucuronosyltransferase 1A1) (UDPGT) (UGT1 1) (UGT1-01) (UGT1 1) (UGT- 1A) (UGT1A) (Bilirubin-specific UDPGT isozyme 1) (HUG-BR1) |
| PDB ID: | |
| Protein Family: | |
| Protein Category: | Enzyme |
This panel provides drug-protein interaction and their ADRs along with references
| Interacting Drugs | Toxicity | Mechanism | Reference |
|---|---|---|---|
| Acetaminophen | Toxicity In Human Hepatocytes | The inhibition of APAP glucuronidation by phenobarbital leads to an increase in APAP-mediated toxicity in human hepatocytes;The toxicity to hepatocytes was further increased by coadministering APAP with phenytoin and phenobarbital;This synergistic increase in toxicity is postulated to be due to inhibition of UGTs. [ ADR Type 4 ] | Kinetics of acetaminophen glucuronidation by UDP-glucuronosyltransferases 1A1, 1A6, 1A9 and 2B15 Potential implications in acetaminophen-induced hepatotoxicity |
| Cimetidine | Hemolytic Anemia | Biochemical examinations revealed that the serum indirect bilirubin and LDH levels were elevated@which indicated the development of hemolytic anemia. [ ADR Type 2 ] | Hemolytic anemia and thrombocytopenia induced by cimetidine: recurrence with ranitidine administration |
| Cimetidine | Thrombocytopenia | Biochemical examinations revealed that the serum indirect bilirubin and LDH levels were elevated@which leads to gradually progressed thrombocytopenia [ ADR Type 2 ] | Hemolytic anemia and thrombocytopenia induced by cimetidine: recurrence with ranitidine administration |
| Prochlorperazine | Disruption Of The Structural Organization | Prochlorperazine disrupts the structural organization between lipids and proteins in microsomal membranes@ altering thereby the activity and regulation of at least two different integral membrane proteins [ ADR Type 2 ] | Effects of prochlorperazine on the function of integral membrane proteins |
This panel provides information on drug category
| Toxicity | Source |
|---|