| Protein Name: | Transcription factor AP-1 (P05412) |
|---|---|
| Gene Name: | JUN |
| Description: | Transcription factor AP-1 (Activator protein 1) (AP1) (Proto-oncogene c-jun) (V-jun avian sarcoma virus 17 oncogene homolog) (p39) |
| PDB ID: | |
| Protein Family: | |
| Protein Category: | Transcription Factor |
This panel provides drug-protein interaction and their ADRs along with references
| Interacting Drugs | Toxicity | Mechanism | Reference |
|---|---|---|---|
| Acetaminophen | Hepatotoxicity | AP-1 transcription factor and Fos-related antigens (fra) as well as Jun proteins are associated in the hepatotoxic response of liver to APAP and may serve as useful molecular biomarkers for chemical-induced hepatotoxicity. [ ADR Type 2 ] | Acetaminophen-induced hepatotoxicity is associated with early changes in AP-1 DNA binding activity |
| Chloroxine | Apoptosis | Expression of immediate early genes@ including c-jun@ c-fos and egr-1@ was also induced by copper treatment in these cells@which suggests copper@in the presence of 8-hydroxyquinoline@ was able to induce apoptosis of murine J774.A1 cells in culture. [ ADR Type 2 ] | Copper-induced apoptosis and immediate early gene expression in macrophages |
| Curcumin | Apoptosis | Pharmacological inhibition of AP1 activity by diferuloylmethane lead to induction of apoptotic cell death and DNA damage [ ADR Type 2 ] | Evidence that the apoptotic actions of etoposide are independent of c-Jun/activating protein-1-mediated transregulation |
| Curcumin | Dna Damage | Pharmacological inhibition of AP1 activity by diferuloylmethane lead to induction of apoptotic cell death and DNA damage [ ADR Type 2 ] | Evidence that the apoptotic actions of etoposide are independent of c-Jun/activating protein-1-mediated transregulation |
| Mitoxantrone | Apoptosis | Intracellularly@ mitoxantrone-induced programmed cell death (PCD) was associated with a marked induction of c-jun and significant repression of c-myc and BCL-2 oncogenes. [ ADR Type 3 ] | High-dose mitoxantrone induces programmed cell death or apoptosis in human myeloid leukemia cells |
| TAM-67 | Molecular Ablation Of Normal C-Jun Function | Molecular ablation of normal c-Jun function by the Jun dominant-negative mutant TAM-67 [ ADR Type 2 3 ] | Evidence that the apoptotic actions of etoposide are independent of c-Jun/activating protein-1-mediated transregulation |
This panel provides information on drug category
| Toxicity | Source |
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