InAADR

Protein Information

Protein Name: Thiopurine S-methyltransferase (P51580)
Gene Name: TPMT
Description: Thiopurine S-methyltransferase (EC 2 1 1 67) (Thiopurine methyltransferase)
PDB ID: 2BZG
Protein Family:
Protein Category: Enzyme

This panel provides drug-protein interaction and their ADRs along with references

Interacting Drugs Toxicity Mechanism Reference
Azathioprine Bone Marrow Toxicity Thiopurine methyltransferase (TPMT) deficiency has been reported as a cause of AZA-related bone marrow toxicity. [ ADR Type 2 3 ] A Azathioprine-related bone marrow toxicity and low activities of purine enzymes in patients with rheumatoid arthritis
Azathioprine Decrease In Vcs-Responsive Cells Hormone-induced decrease in VCS-responsive cells [ ADR Type 1 ] Identification of thiopurine methyltransferase (TPMT) polymorphisms cannot predict myelosuppression in systemic lupus erythematosus patients taking azathioprine Rheumatology
Azathioprine Myelotoxicity Myelotoxicity [ ADR Type 2 ] Pharmacogenetics in cancer chemotherapy: balancing toxicity and response
Esmolol Diarrhoea Diarrhoea [ ADR Type 2 ] Pharmacogenetics in cancer chemotherapy: balancing toxicity and response
Esmolol Myelosuppression Myelosuppression [ ADR Type 1 ] Pharmacogenetics in cancer chemotherapy: balancing toxicity and response
Mercaptopurine Myelotoxicity Myelotoxicity [ ADR Type 2 ] Pharmacogenetics in cancer chemotherapy: balancing toxicity and response
Mercuric Chloride Autoimmune Syndrome And Necrotizing Leucocytoclastic Vasculitis Mercuric chloride (HgCl2) treatment induces an autoimmune syndrome and necrotizing leucocytoclastic vasculitis in the Brown Norway (BN) rat. [ ADR Type 5 ] Human lymphocyte thiopurine methyltransferase pharmacogenetics: effect of phenotype on 6-mercaptopurine-induced inhibition of mitogen stimulation
Thioguanine Myelotoxicity Myelotoxicity [ ADR Type 2 ] Pharmacogenetics in cancer chemotherapy: balancing toxicity and response

This panel provides information on drug category

Toxicity Source

InAADR: Drug-Protein-ADRs database