InAADR

Protein Information

Protein Name: Adiponectin (Q15848)
Gene Name: ADIPOQ
Description: Adiponectin precursor (Adipocyte, C1q and collagen domain-containing protein) (30 kDa adipocyte complement-related protein) (ACRP30) (Adipose most abundant gene transcript 1) (apM-1) (Gelatin-binding protein)
PDB ID: 4DOU
Protein Family:
Protein Category:

This panel provides drug-protein interaction and their ADRs along with references

Interacting Drugs Toxicity Mechanism Reference
Amprenavir Hyperlipidemia Dose-responsive inhibition of adipogenesis by amprenavir was noted as measured by reduced triglyceride accumulation and attenuated induction of three differentiation marker genes -- aP2@ lipoprotein lipase@ and Adipo Q@which leads to a syndrome characterized by lipodystrophy (fat redistribution favoring the accumulation of abdominal and cervical adipose tissue)@ hyperlipidemia@ and insulin resistance [ ADR Type 1 ] Inhibition of adipocyte differentiation by HIV protease inhibitors
Amprenavir Insulin Resistance Dose-responsive inhibition of adipogenesis by amprenavir was noted as measured by reduced triglyceride accumulation and attenuated induction of three differentiation marker genes -- aP2@ lipoprotein lipase@ and Adipo Q@which leads to a syndrome characterized by lipodystrophy (fat redistribution favoring the accumulation of abdominal and cervical adipose tissue)@ hyperlipidemia@ and insulin resistance [ ADR Type 1 ] Inhibition of adipocyte differentiation by HIV protease inhibitors
Amprenavir Lipodystrophy Dose-responsive inhibition of adipogenesis by amprenavir was noted as measured by reduced triglyceride accumulation and attenuated induction of three differentiation marker genes -- aP2@ lipoprotein lipase@ and Adipo Q@which leads to a syndrome characterized by lipodystrophy (fat redistribution favoring the accumulation of abdominal and cervical adipose tissue)@ hyperlipidemia@ and insulin resistance [ ADR Type 1 ] Inhibition of adipocyte differentiation by HIV protease inhibitors
Indinavir Hyperlipidemia Dose-responsive inhibition of adipogenesis by indinavir was noted as measured by reduced triglyceride accumulation and attenuated induction of three differentiation marker genes -- aP2@ lipoprotein lipase@ and Adipo Q@which leads to a syndrome characterized by lipodystrophy (fat redistribution favoring the accumulation of abdominal and cervical adipose tissue)@ hyperlipidemia@ and insulin resistance. [ ADR Type 1 ] Inhibition of adipocyte differentiation by HIV protease inhibitors
Indinavir Insulin Resistance Dose-responsive inhibition of adipogenesis by indinavir was noted as measured by reduced triglyceride accumulation and attenuated induction of three differentiation marker genes -- aP2@ lipoprotein lipase@ and Adipo Q@which leads to a syndrome characterized by lipodystrophy (fat redistribution favoring the accumulation of abdominal and cervical adipose tissue)@ hyperlipidemia@ and insulin resistance. [ ADR Type 1 ] Inhibition of adipocyte differentiation by HIV protease inhibitors
Indinavir Lipodystrophy Dose-responsive inhibition of adipogenesis by indinavir was noted as measured by reduced triglyceride accumulation and attenuated induction of three differentiation marker genes -- aP2@ lipoprotein lipase@ and Adipo Q@which leads to a syndrome characterized by lipodystrophy (fat redistribution favoring the accumulation of abdominal and cervical adipose tissue)@ hyperlipidemia@ and insulin resistance. [ ADR Type 1 ] Inhibition of adipocyte differentiation by HIV protease inhibitors
Nelfinavir Hyperlipidemia Dose-responsive inhibition of adipogenesis by nelfinavir was noted as measured by reduced triglyceride accumulation and attenuated induction of three differentiation marker genes -- aP2@ lipoprotein lipase@ and Adipo Q@which leads to a syndrome characterized by lipodystrophy (fat redistribution favoring the accumulation of abdominal and cervical adipose tissue)@ hyperlipidemia@ and insulin resistance. [ ADR Type 1 ] Inhibition of adipocyte differentiation by HIV protease inhibitors
Nelfinavir Insulin Resistance Dose-responsive inhibition of adipogenesis by nelfinavir was noted as measured by reduced triglyceride accumulation and attenuated induction of three differentiation marker genes -- aP2@ lipoprotein lipase@ and Adipo Q@which leads to a syndrome characterized by lipodystrophy (fat redistribution favoring the accumulation of abdominal and cervical adipose tissue)@ hyperlipidemia@ and insulin resistance. [ ADR Type 1 ] Inhibition of adipocyte differentiation by HIV protease inhibitors
Nelfinavir Lipodystrophy Dose-responsive inhibition of adipogenesis by nelfinavir was noted as measured by reduced triglyceride accumulation and attenuated induction of three differentiation marker genes -- aP2@ lipoprotein lipase@ and Adipo Q@which leads to a syndrome characterized by lipodystrophy (fat redistribution favoring the accumulation of abdominal and cervical adipose tissue)@ hyperlipidemia@ and insulin resistance. [ ADR Type 1 ] Inhibition of adipocyte differentiation by HIV protease inhibitors
Ritonavir Hyperlipidemia Dose-responsive inhibition of adipogenesis by ritonavir was noted as measured by reduced triglyceride accumulation and attenuated induction of three differentiation marker genes -- aP2@ lipoprotein lipase@ and Adipo Q@which leads to a syndrome characterized by lipodystrophy (fat redistribution favoring the accumulation of abdominal and cervical adipose tissue)@ hyperlipidemia@ and insulin resistance [ ADR Type 1 ] Inhibition of adipocyte differentiation by HIV protease inhibitors
Ritonavir Insulin Resistance Dose-responsive inhibition of adipogenesis by ritonavir was noted as measured by reduced triglyceride accumulation and attenuated induction of three differentiation marker genes -- aP2@ lipoprotein lipase@ and Adipo Q@which leads to a syndrome characterized by lipodystrophy (fat redistribution favoring the accumulation of abdominal and cervical adipose tissue)@ hyperlipidemia@ and insulin resistance [ ADR Type 1 ] Inhibition of adipocyte differentiation by HIV protease inhibitors
Ritonavir Lipodystrophy Dose-responsive inhibition of adipogenesis by ritonavir was noted as measured by reduced triglyceride accumulation and attenuated induction of three differentiation marker genes -- aP2@ lipoprotein lipase@ and Adipo Q@which leads to a syndrome characterized by lipodystrophy (fat redistribution favoring the accumulation of abdominal and cervical adipose tissue)@ hyperlipidemia@ and insulin resistance [ ADR Type 1 ] Inhibition of adipocyte differentiation by HIV protease inhibitors

This panel provides information on drug category

Toxicity Source

InAADR: Drug-Protein-ADRs database