InAADR

Protein Information

Protein Name: Phosphatidylinositol-4-phosphate 3-kinase (O00443)
Gene Name: PIK3C2A
Description: Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha polypeptide (EC 2 7 1 154) (Phosphoinositide 3-Kinase-C2-alpha) (PtdIns-3-kinase C2 alpha) (PI3K-C2alpha)
PDB ID: 2AR5
Protein Family:
Protein Category: Enzyme

This panel provides drug-protein interaction and their ADRs along with references

Interacting Drugs Toxicity Mechanism Reference
Dehydrated Alcohol Impair Liver Regeneration Ethanol treatment is associated with phosphatidylinositol-3 kinase with tyrosyl-phosphorylated IRS-1, and MAP kinase and phosphatidylinositol-3 kinase activities,suggesting that ethanol treatment substantially inhibits IRS-1 and MAP kinase signaling and growth-associated gene expression,which leads to chronic ethanol toxicity impairs liver regeneration, inhibits DNA synthesis, and mutes cellular responses to growth factor stimulation [ ADR Type 1 ] Ethanol inhibition of insulin signaling in hepatocellular carcinoma cells
Dehydrated Alcohol Inhibit Dna Synthesis Ethanol treatment is associated with phosphatidylinositol-3 kinase with tyrosyl-phosphorylated IRS-1, and MAP kinase and phosphatidylinositol-3 kinase activities,suggesting that ethanol treatment substantially inhibits IRS-1 and MAP kinase signaling and growth-associated gene expression,which leads to chronic ethanol toxicity impairs liver regeneration, inhibits DNA synthesis, and mutes cellular responses to growth factor stimulation [ ADR Type 1 ] Ethanol inhibition of insulin signaling in hepatocellular carcinoma cells
Dehydrated Alcohol Mute Cellular Responses To Growth Factor Stimulation Ethanol treatment is associated with phosphatidylinositol-3 kinase with tyrosyl-phosphorylated IRS-1, and MAP kinase and phosphatidylinositol-3 kinase activities,suggesting that ethanol treatment substantially inhibits IRS-1 and MAP kinase signaling and growth-associated gene expression,which leads to chronic ethanol toxicity impairs liver regeneration, inhibits DNA synthesis, and mutes cellular responses to growth factor stimulation [ ADR Type 1 ] Ethanol inhibition of insulin signaling in hepatocellular carcinoma cells

This panel provides information on drug category

Toxicity Source

InAADR: Drug-Protein-ADRs database