| Protein Name: | Perforin (P14222) |
|---|---|
| Gene Name: | PRF1 |
| Description: | Perforin-1 precursor (P1) (Lymphocyte pore-forming protein) (PFP) (Cytolysin) |
| PDB ID: | |
| Protein Family: | |
| Protein Category: | Ion Channels |
This panel provides drug-protein interaction and their ADRs along with references
| Interacting Drugs | Toxicity | Mechanism | Reference |
|---|---|---|---|
| Pentoxifylline | Inhibitory Effect | Anti-CD3-activated killer (AK) cell expression of the cytoplasmic granule-associated cytolytic effector molecules granzyme B and perforin was markedly reduced when AK cells were induced in the presence of Pentoxifylline(PTX),PTX thus has a profound inhibitory effect in vitro on the induction of granule-dependent cytolytic effector mechanisms in a mouse model system [ ADR Type 5 ] | Pentoxifylline inhibits granzyme B and perforin expression following T-lymphocyte activation by anti-CD3 antibody |
This panel provides information on drug category
| Toxicity | Source |
|---|