| Protein Name: | Defender against cell death 1 (P61803) |
|---|---|
| Gene Name: | DAD1 |
| Description: | Defender against cell death 1 (DAD-1) |
| PDB ID: | |
| Protein Family: | |
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This panel provides drug-protein interaction and their ADRs along with references
| Interacting Drugs | Toxicity | Mechanism | Reference |
|---|---|---|---|
| Paclitaxel | Apoptosis | Paclitaxel-induced apoptosis of breast cancer cells.Expression of the anti-apoptotic tumor necrosis factor receptor associated factor 1 (TRAF1) and defender-against cell death (DAD-1) is regulated by NF-kappaB in certain breast cancer cells. [ ADR Type 2 ] | Paclitaxel sensitivity of breast cancer cells with constitutively active NF-kappaB is enhanced by IkappaBalpha super-repressor |
| Paclitaxel | Apoptosis Of Breast Cancer Cells | Expression of the anti-apoptotic tumor necrosis factor receptor associated factor 1 (TRAF1) and defender-against cell death (DAD-1) is regulated by NF-kappaB in certain breast cancer cells@which increases paclitaxel-induced apoptosis of breast cancer cells. [ ADR Type 2 ] | Paclitaxel sensitivity of breast cancer cells with constitutively active NF-kappaB is enhanced by IkappaBalpha super-repressor |
This panel provides information on drug category
| Toxicity | Source |
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