| Protein Name: | GPI-linked NAD (P)(+)--arginine ADP-ribosyltransferase (P52961) |
|---|---|
| Gene Name: | BCHE |
| Description: | GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1 precursor (EC 2 4 2 31) (Mono(ADP-ribosyl)transferase) (CD296 antigen) |
| PDB ID: | |
| Protein Family: | |
| Protein Category: | Enzyme |
This panel provides drug-protein interaction and their ADRs along with references
| Interacting Drugs | Toxicity | Mechanism | Reference |
|---|---|---|---|
| Uracil Mustard | Cell Death | In cultured human epidermal cells exposure to the vesicant sulfur mustard (HD) causes a decrease of the NAD+ content@this NAD+ loss is due to activation of the enzyme NAD:protein ADP-ribosyltransferase (ADPRT) and may lead to eventually cell death. [ ADR Type 1 ] | NAD+ levels and glucose uptake of cultured human epidermal cells exposed to sulfur mustard |
| Uracil Mustard | Disturbance Of Energy Metabolism | In cultured human epidermal cells exposure to the vesicant sulfur mustard (HD) causes a decrease of the NAD+ content@this NAD+ loss is due to activation of the enzyme NAD:protein ADP-ribosyltransferase (ADPRT) and may lead to disturbance of energy metabolism [ ADR Type 1 ] | NAD+ levels and glucose uptake of cultured human epidermal cells exposed to sulfur mustard |
| Uracil Mustard | Glycolysis Inhibition | In cultured human epidermal cells exposure to the vesicant sulfur mustard (HD) causes a decrease of the NAD+ content@this NAD+ loss is due to activation of the enzyme NAD:protein ADP-ribosyltransferase (ADPRT) and may lead to glycolysis inhibition [ ADR Type 1 ] | NAD+ levels and glucose uptake of cultured human epidermal cells exposed to sulfur mustard |
This panel provides information on drug category
| Toxicity | Source |
|---|