| Protein Name: | Methylenetetrahydrofolate reductase (P42898) |
|---|---|
| Gene Name: | MTHFR |
| Description: | |
| PDB ID: | |
| Protein Family: | PF02219 |
| Protein Category: |
This panel provides drug-protein interaction and their ADRs along with references
| Interacting Drugs | Toxicity | Mechanism | Reference |
|---|---|---|---|
| Methionine | Lipoprotein Peroxidation | Genetic defects such as cystathionine beta-synthase or methylene-tetrahydrofolate reductase may contribute to increasing plasma homocysteine levels@which could lead to the pathogenesis of Hcy(formed by demethylation of methionine)-induced vascular damage may be multifactorial@ including direct Hcy damage to the endothelium@ stimulation of proliferation of smooth muscle cells@ enhanced low-density lipoprotein peroxidation@ increase of platelet aggregation@ and effects on the coagulation system. [ ADR Type 3 ] | Hyperhomocysteinemia: atherothrombosis and neurotoxicity |
| Methionine | Platelet Aggregation | Genetic defects such as cystathionine beta-synthase or methylene-tetrahydrofolate reductase may contribute to increasing plasma homocysteine levels@which could lead to the pathogenesis of Hcy(formed by demethylation of methionine)-induced vascular damage may be multifactorial@ including direct Hcy damage to the endothelium@ stimulation of proliferation of smooth muscle cells@ enhanced low-density lipoprotein peroxidation@ increase of platelet aggregation@ and effects on the coagulation system. [ ADR Type 3 ] | Hyperhomocysteinemia: atherothrombosis and neurotoxicity |
This panel provides information on drug category