InAADR

Protein Information

Protein Name: Sterol regulatory element-binding protein 1 (P36956)
Gene Name: SREBF1
Description: Sterol regulatory element-binding protein 1 (SREBP-1) (Sterol regulatory element-binding transcription factor 1)
PDB ID: 1AM9
Protein Family:
Protein Category:

This panel provides drug-protein interaction and their ADRs along with references

Interacting Drugs Toxicity Mechanism Reference
Ritonavir Abnormality Of Hepatic Steatosis Abnormality of hepatic steatosis after Ritonavir treatment is due to ritonavir-induced accumulation of the activated forms of sterol regulatory binding protein (SREBP)-1 in the nucleus of liver and adipose@ resulting in elevated expression of lipid metabolism genes [ ADR Type 1 ] HIV protease inhibitor induces fatty acid and sterol biosynthesis in liver and adipose tissues due to the accumulation of activated sterol regulatory element-binding proteins in the nucleus
Ritonavir Abnormality Of Hepatomegaly Abnormality of hepatomegaly after Ritonavir treatment is due to ritonavir-induced accumulation of the activated forms of sterol regulatory binding protein (SREBP)-1 in the nucleus of liver and adipose@ resulting in elevated expression of lipid metabolism genes [ ADR Type 1 ] HIV protease inhibitor induces fatty acid and sterol biosynthesis in liver and adipose tissues due to the accumulation of activated sterol regulatory element-binding proteins in the nucleus
Troglitazone Obesity Hepatic SREBP-1 mRNA was 2.4 times higher than in lean +/+ controls@ primarily because of increased SREBP-1c expression@which may play a role in the ectopic lipogenesis and lipotoxicity complicating obesity in Zucker diabetic fatty rats. [ ADR Type 1 ] Leptin, troglitazone, and the expression of sterol regulatory element binding proteins in liver and pancreatic islets

This panel provides information on drug category

Toxicity Source

InAADR: Drug-Protein-ADRs database