InAADR

Protein Information

Protein Name: Cytochrome P450 (P15538)
Gene Name: CYP11B1
Description: Cytochrome P450 11B1, mitochondrial precursor (EC 114154) (CYPXIB1) (P450C11) (P-450c11) (Steroid 11-beta-hydroxylase)
PDB ID:
Protein Family:
Protein Category: Enzyme

This panel provides drug-protein interaction and their ADRs along with references

Interacting Drugs Toxicity Mechanism Reference
Acetaminophen Renal Functional Changes APAP-induced renal functional changes(elevation in blood urea nitrogen and reduction in the accumulation of p-aminohippurate by renal cortical slices) also correlated with strain-dependent histopathological changes. Such strain differences have been attributed to differences in renal P-450 activation of APAP or the deacetylation of APAP to the nephrotoxic metabolite@ p-aminophenol (PAP). [ ADR Type 1 ] Acetaminophen nephrotoxicity in the rat I Strain differences in nephrotoxicity and metabolism

This panel provides information on drug category

Toxicity Source

InAADR: Drug-Protein-ADRs database