InAADR

Protein Information

Protein Name: D(2) dopamine receptor (P14416)
Gene Name: DRD2
Description:
PDB ID: 1I15
Protein Family: PF00001, PS00237
Protein Category: Membrane Receptors

This panel provides drug-protein interaction and their ADRs along with references

Interacting Drugs Toxicity Mechanism Reference
Chlorpromazine Akathisia Antipsychotic response (D2@ D3@ D4)@antipsychotic-induced tardive dyskinesia (D3)@antipsychotic-induced acute akathisia (D3) [ ADR Type 2 ] Pharmacogenetics and antipsychotic drugs
Chlorpromazine Tardive Dyskinesia Antipsychotic response (D2@ D3@ D4)@antipsychotic-induced tardive dyskinesia (D3)@antipsychotic-induced acute akathisia (D3) [ ADR Type 2 ] Pharmacogenetics and antipsychotic drugs
Clozapine Akathisia Antipsychotic response (D2@ D3@ D4)@antipsychotic-induced tardive dyskinesia (D3)@antipsychotic-induced acute akathisia (D3) [ ADR Type 2 ] Pharmacogenetics and antipsychotic drugs
Clozapine Tardive Dyskinesia Antipsychotic response (D2@ D3@ D4)@antipsychotic-induced tardive dyskinesia (D3)@antipsychotic-induced acute akathisia (D3) [ ADR Type 2 ] Pharmacogenetics and antipsychotic drugs
Dehydrated Alcohol Pancreatitis Alcohol induced chronic pancreatitis [ ADR Type 1 ] Male limited association of the dopamine receptor D2 gene TaqI a polymorphism and alcohol dependence
Diperodon Bradycardia Not Available Large-scale prediction and testing of drug activity on side-effect targets
Droperidol Akathisia Antipsychotic response (D2@ D3@ D4)@antipsychotic-induced tardive dyskinesia (D3)@antipsychotic-induced acute akathisia (D3) [ ADR Type 2 ] Pharmacogenetics and antipsychotic drugs
Droperidol Tardive Dyskinesia Antipsychotic response (D2@ D3@ D4)@antipsychotic-induced tardive dyskinesia (D3)@antipsychotic-induced acute akathisia (D3) [ ADR Type 2 ] Pharmacogenetics and antipsychotic drugs
Flupenthixol Akathisia Antipsychotic response (D2@ D3@ D4)@antipsychotic-induced tardive dyskinesia (D3)@antipsychotic-induced acute akathisia (D3) [ ADR Type 2 ] Pharmacogenetics and antipsychotic drugs
Flupenthixol Tardive Dyskinesia Antipsychotic response (D2@ D3@ D4)@antipsychotic-induced tardive dyskinesia (D3)@antipsychotic-induced acute akathisia (D3) [ ADR Type 2 ] Pharmacogenetics and antipsychotic drugs
Fluphenazine Akathisia Antipsychotic response (D2@ D3@ D4)@antipsychotic-induced tardive dyskinesia (D3)@antipsychotic-induced acute akathisia (D3). [ ADR Type 2 ] Pharmacogenetics and antipsychotic drugs
Fluphenazine Tardive Dyskinesia Antipsychotic response (D2@ D3@ D4)@antipsychotic-induced tardive dyskinesia (D3)@antipsychotic-induced acute akathisia (D3). [ ADR Type 2 ] Pharmacogenetics and antipsychotic drugs
Haloperidol Akathisia Antipsychotic response (D2@ D3@ D4)@antipsychotic-induced tardive dyskinesia (D3)@antipsychotic-induced acute akathisia (D3) [ ADR Type 2 ] Pharmacogenetics and antipsychotic drugs
Haloperidol Tardive Dyskinesia Antipsychotic response (D2@ D3@ D4)@antipsychotic-induced tardive dyskinesia (D3)@antipsychotic-induced acute akathisia (D3) [ ADR Type 2 ] Pharmacogenetics and antipsychotic drugs
Olanzapine Akathisia Antipsychotic response (D2@ D3@ D4)@antipsychotic-induced tardive dyskinesia (D3)@antipsychotic-induced acute akathisia (D3). [ ADR Type 2 ] Pharmacogenetics and antipsychotic drugs
Olanzapine Tardive Dyskinesia Antipsychotic response (D2@ D3@ D4)@antipsychotic-induced tardive dyskinesia (D3)@antipsychotic-induced acute akathisia (D3). [ ADR Type 2 ] Pharmacogenetics and antipsychotic drugs
Risperidone Akathisia Antipsychotic response (D2@ D3@ D4)@antipsychotic-induced tardive dyskinesia (D3)@antipsychotic-induced acute akathisia (D3) [ ADR Type 2 ] Pharmacogenetics and antipsychotic drugs
Risperidone Tardive Dyskinesia Antipsychotic response (D2@ D3@ D4)@antipsychotic-induced tardive dyskinesia (D3)@antipsychotic-induced acute akathisia (D3) [ ADR Type 2 ] Pharmacogenetics and antipsychotic drugs
Thioridazine Akathisia Antipsychotic response (D2@ D3@ D4)@antipsychotic-induced tardive dyskinesia (D3)@antipsychotic-induced acute akathisia (D3). [ ADR Type 2 ] Pharmacogenetics and antipsychotic drugs
Thioridazine Tardive Dyskinesia Antipsychotic response (D2@ D3@ D4)@antipsychotic-induced tardive dyskinesia (D3)@antipsychotic-induced acute akathisia (D3). [ ADR Type 2 ] Pharmacogenetics and antipsychotic drugs
Trifluoperazine Akathisia Antipsychotic response (D2@ D3@ D4)@antipsychotic-induced tardive dyskinesia (D3)@antipsychotic-induced acute akathisia (D3) [ ADR Type 2 ] Pharmacogenetics and antipsychotic drugs
Trifluoperazine Tardive Dyskinesia Antipsychotic response (D2@ D3@ D4)@antipsychotic-induced tardive dyskinesia (D3)@antipsychotic-induced acute akathisia (D3) [ ADR Type 2 ] Pharmacogenetics and antipsychotic drugs
zuclopenthixol Akathisia Antipsychotic response (D2@ D3@ D4)@antipsychotic-induced tardive dyskinesia (D3)@antipsychotic-induced acute akathisia (D3). [ ADR Type 2 ] Pharmacogenetics and antipsychotic drugs
zuclopenthixol Tardive Dyskinesia Antipsychotic response (D2@ D3@ D4)@antipsychotic-induced tardive dyskinesia (D3)@antipsychotic-induced acute akathisia (D3). [ ADR Type 2 ] Pharmacogenetics and antipsychotic drugs

This panel provides information on drug category

Toxicity Source
Akathisia Large-scale prediction and testing of drug activity on side-effect targets
Amenorrhoea Large-scale prediction and testing of drug activity on side-effect targets
Cataract Large-scale prediction and testing of drug activity on side-effect targets
Cholestasis Large-scale prediction and testing of drug activity on side-effect targets
Constipation Large-scale prediction and testing of drug activity on side-effect targets
Convulsion Large-scale prediction and testing of drug activity on side-effect targets
Corneal Opacity Large-scale prediction and testing of drug activity on side-effect targets
Corneal Pigmentation Large-scale prediction and testing of drug activity on side-effect targets
Dermatitis Allergic Large-scale prediction and testing of drug activity on side-effect targets
Dermatitis Exfoliative Large-scale prediction and testing of drug activity on side-effect targets
Dry Mouth Large-scale prediction and testing of drug activity on side-effect targets
Dyskinesia Large-scale prediction and testing of drug activity on side-effect targets
Dystonia Large-scale prediction and testing of drug activity on side-effect targets
Ejaculation Disorder Large-scale prediction and testing of drug activity on side-effect targets
Electrocardiogram Change Large-scale prediction and testing of drug activity on side-effect targets
Endocrine Disorder Large-scale prediction and testing of drug activity on side-effect targets
Erectile Dysfunction Large-scale prediction and testing of drug activity on side-effect targets
Extrapyramidal Disorder Large-scale prediction and testing of drug activity on side-effect targets
Eyelash Discolouration Large-scale prediction and testing of drug activity on side-effect targets
Fibrocystic Breast Disease Large-scale prediction and testing of drug activity on side-effect targets
Galactorrhoea Large-scale prediction and testing of drug activity on side-effect targets
Gynaecomastia Large-scale prediction and testing of drug activity on side-effect targets
Hypercholesterolaemia Large-scale prediction and testing of drug activity on side-effect targets
Hyperprolactinaemia Large-scale prediction and testing of drug activity on side-effect targets
Hyperthermia Large-scale prediction and testing of drug activity on side-effect targets
Hypothermia Large-scale prediction and testing of drug activity on side-effect targets
Insomnia Large-scale prediction and testing of drug activity on side-effect targets
Lenticular Opacities Large-scale prediction and testing of drug activity on side-effect targets
Lipid Metabolism Disorder Large-scale prediction and testing of drug activity on side-effect targets
Menstrual Disorder Large-scale prediction and testing of drug activity on side-effect targets
Miosis Large-scale prediction and testing of drug activity on side-effect targets
Mydriasis Large-scale prediction and testing of drug activity on side-effect targets
Nasal Congestion Large-scale prediction and testing of drug activity on side-effect targets
Neuroleptic Malignant Syndrome Large-scale prediction and testing of drug activity on side-effect targets
Orthostatic Hypotension Large-scale prediction and testing of drug activity on side-effect targets
Parkinsonism Large-scale prediction and testing of drug activity on side-effect targets
Sexual Dysfunction Large-scale prediction and testing of drug activity on side-effect targets
Tachycardia Large-scale prediction and testing of drug activity on side-effect targets
Tardive Dyskinesia Large-scale prediction and testing of drug activity on side-effect targets
Urinary Retention Large-scale prediction and testing of drug activity on side-effect targets
Vision Blurred Large-scale prediction and testing of drug activity on side-effect targets
Weight Increased Large-scale prediction and testing of drug activity on side-effect targets

InAADR: Drug-Protein-ADRs database