| Protein Name: | Glutathione s-transferase (P09211) |
|---|---|
| Gene Name: | GSTP1 |
| Description: | |
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This panel provides drug-protein interaction and their ADRs along with references
| Interacting Drugs | Toxicity | Mechanism | Reference |
|---|---|---|---|
| Cisplatin | Nephrotoxicity | Glutathione s-transferase (substrate: 1-chloro-2@4-dinitrobenzene) was increased and decreased by cadmium and cisplatin respectively@which leads to cadmium nephrotoxicity was characterized by tubular proximal damage with mitochondrial and lysosomal changes and a widespread vesiculation of tubular cells [ ADR Type 2 ] | Cisplatin nephrotoxicity in cadmium-pretreated rats Enzymatic, functional and morphological studies |
| Paclitaxel | Apoptosis | Apoptosis [ ADR Type 2 ] | Paclitaxel-induced apoptosis is associated with expression and activation of c-Mos gene product in human ovarian carcinoma SKOV3 cells |
This panel provides information on drug category
| Toxicity | Source |
|---|---|
| Nephrotoxicity | Cisplatin nephrotoxicity in cadmium-pretreated rats Enzymatic, functional and morphological studies |