| Protein Name: | Epoxide hydrolase (P07099) |
|---|---|
| Gene Name: | EPHX1 |
| Description: | Epoxide hydrolase 1 (EC 3323) (Microsomal epoxide hydrolase) (Epoxide hydratase) |
| PDB ID: | |
| Protein Family: | |
| Protein Category: | Enzyme |
This panel provides drug-protein interaction and their ADRs along with references
| Interacting Drugs | Toxicity | Mechanism | Reference |
|---|---|---|---|
| Carbamazepine | Hypersensitivity Reactions | Idiosyncratic hypersensitivity reactions with carbamazepine have been postulated to be due to a deficiency of microsomal Epoxide hydrolase (HYL1). [ ADR Type 2 ] | Genetic analysis of microsomal epoxide hydrolase in patients with carbamazepine hypersensitivity |
| Indomethacin | Selective Effect Of A P-Chlorophenyl Moiety | Indomethacin in vitro also caused a loss of cytochrome b5@ NADH-cytochrome b5 reductase@ NADPH-cytochrome c reductase and Epoxide hydrolase activities@ but an activation of UDP-glucuronyltransferase@which leads to selective effect of a p-chlorophenyl moiety. [ ADR Type 1 ] | Denaturation of cytochrome P-450 by indomethacin and other non-steroidal anti-inflammatory drugs: evidence for a surfactant mechanism and a selective effect of a p-chlorophenyl moiety |
| Mitoxantrone | Mitozantrone Toxicity | Inhibition of Epoxide hydrolase potentiated mitozantrone toxicity. [ ADR Type 1 ] | The toxicity of menadione and mitozantrone in human liver-derived Hep G2 hepatoma cells |
This panel provides information on drug category
| Toxicity | Source |
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