InAADR

Protein Information

Protein Name: Alkaline phosphatase (P05187)
Gene Name: ALPP
Description: Alkaline phosphatase, placental type precursor (EC 3 1 3 1) (PLAP-1) (Regan isozyme)
PDB ID: 1EW2
Protein Family:
Protein Category: Enzyme

This panel provides drug-protein interaction and their ADRs along with references

Interacting Drugs Toxicity Mechanism Reference
Dexamethasone Osteoblast Differentiation Dexamethasone effects on certain osteoblast differentiated features@ such as induction of alkaline phosphatase activity are not strictly dependent on cadherin function [ ADR Type 1 ] Differential regulation of cadherins by dexamethasone in human osteoblastic cells
Lidocaine Fever The elevation of glutamic oxalacetic transaminase (GOT)@ glutamic pyruvic transaminase (GPT)@ alkaline phosphatase (ALP)@ and gamma glutamyltrans peptidase (gamma-GTP)@ C reactive protein (CRP)@ and blood sedimentation rate (BSR)@suggest strongly that 0.5% lidocaine induced fever. [ ADR Type 2 ] Unknown fever and abnormal liver functions after repeated epidural blocks with lidocaine for management of herpes zoster pain
Lidocaine Hepatitis The elevation of glutamic oxalacetic transaminase (GOT)@ glutamic pyruvic transaminase (GPT)@ alkaline phosphatase (ALP)@ and gamma glutamyltrans peptidase (gamma-GTP)@ C reactive protein (CRP)@ and blood sedimentation rate (BSR)@suggest strongly that 0 5% lidocaine induced hepatitis [ ADR Type 2 ] Unknown fever and abnormal liver functions after repeated epidural blocks with lidocaine for management of herpes zoster pain
Paricalcitol Oversuppression Of Pth Paricalcitol increased serum calcium levels and decreased PTH and bone alkaline phosphatase levels (all P [ ADR Type 1 ] A placebo-controlled trial to evaluate immunomodulatory effects of paricalcitol
Titanocene dichloride (TD) Liver Toxicity Bilirubin and alkaline phosphatase elevation@which lead to liver toxicity. [ ADR Type 1 ] Clinical Trial of a Day-1, -3, -5 Every 3 WeeksPhase I Clinical Trial of Day-1, -3, -5 Every 3 Weeks Schedule with Titanocene Dichloride (MKT 5)

This panel provides information on drug category

Toxicity Source

InAADR: Drug-Protein-ADRs database