InAADR

Protein Information

Protein Name: Angiotensinogen precursor (P01019)
Gene Name: AGT
Description:
PDB ID: 1N9U
Protein Family: PF00079, PS00284
Protein Category:

This panel provides drug-protein interaction and their ADRs along with references

Interacting Drugs Toxicity Mechanism Reference
Estradiol Luteinizing Hormone Surge Dynamic changes in hypothalamic angiotensin II levels and release in association with progesterone-induced luteinizing hormone surge,which is associated with progesterone-induced luteinizing hormone surge. [ ADR Type 1 ] Dynamic changes in hypothalamic angiotensin II levels and release in association with progesterone-induced luteinizing hormone surge
Progesterone Luteinizing Hormone Surge Dynamic changes in hypothalamic angiotensin II levels and release in association with progesterone-induced luteinizing hormone surge,which is associated with progesterone-induced luteinizing hormone surge [ ADR Type 1 ] Dynamic changes in hypothalamic angiotensin II levels and release in association with progesterone-induced luteinizing hormone surge
Sertraline Dry Mouth Not Available Large-scale prediction and testing of drug activity on side-effect targets

This panel provides information on drug category

Toxicity Source
Albuminuria Sex differences in the pressor response to angiotensin II when the endogenous renin-angiotensin system is blocked
Atherosclerotic Vascular Disease Critical role of bone marrow angiotensin II type 1 receptor in the pathogenesis of atherosclerosis in apolipoprotein E deficient mice
Bradycardia Actions of angiotensin peptides after partial denervation of the solitary tract nucleus
Chronic Renal Failure A novel phosphoinositide 3-kinase-dependent pathway for angiotensin II/AT-1 receptor-mediated induction of collagen synthesis in MES-13 mesangial cells
Diabetic Nephropathy Activation of a local renin angiotensin system in podocytes by glucose
Essential Hypertension Genetic polymorphisms of angiotensinogen and essential hypertension in a Tibetan population
Fibrosis Angiotensin II activates the Smad pathway during epithelial mesenchymal transdifferentiation
Hypernatremia Angiotensin II increases intrarenal transforming growth factor-beta1 in rats submitted to sodium overload independently of blood pressure
Hypertension Angiotensin II-induced hypertension regulates AT1 receptor subtypes and extracellular matrix turnover in mouse retinal pigment epithelium
Hypotension Baroreflex modulation by angiotensins at the rat rostral and caudal ventrolateral medulla
Increased Blood Pressure Atorvastatin prevents angiotensin II-induced vascular remodeling and oxidative stress
Nephrosclerosis Mechanisms mediating the renal profibrotic actions of vasoactive peptides in transgenic mice
Renal Failure Severe neonatal renal failure after maternal use of angiotensin II type I receptor antagonists
Tachycardia Positive chronotropic activity of angiotensin II in the pithed normotensive rat is primarily due to activation of cardiac beta 1-adrenoceptors
Toxemia Of Pregnancy Role of the renin-angiotensin system in the pathogenesis of preeclampsia
Type 2 Diabetes Angiotensin II and the development of insulin resistance: implications for diabetes
Vascular Disease Monocyte chemoattractant protein-1 or macrophage inflammatory protein-1alpha deficiency does not affect angiotensin II-induced intimal hyperplasia in carotid artery ligation model

InAADR: Drug-Protein-ADRs database