| Protein Name: | p21(Waf1) (P00039) |
|---|---|
| Gene Name: | Not Available |
| Description: | |
| PDB ID: | |
| Protein Family: | |
| Protein Category: |
This panel provides drug-protein interaction and their ADRs along with references
| Interacting Drugs | Toxicity | Mechanism | Reference |
|---|---|---|---|
| Zidovudine | Tumor Cell Death | Inhibition of telomerase activity,progressive telomere shortening and increase p14(ARF) expression,elicit stabilization and reactivation of the tumor suppressor p53-dependent transcription, increased expression of the cyclin-dependent kinase inhibitor p21(Waf1) and accumulation of p27(kip1), thereby inducing cellular senescence and tumor cell death [ ADR Type 1 ] | Persistent inhibition of telomerase reprograms adult T-cell leukemia to p53-dependent senescence |
This panel provides information on drug category
| Toxicity | Source |
|---|