InAADR

Protein Information

Protein Name: Muscarinic acetylcholine receptor M1 (P11229)
Gene Name: CHRM1
Description:
PDB ID: 5CXV
Protein Family: PF00001, PS00237
Protein Category: Membrane Receptors

This panel provides drug-protein interaction and their ADRs along with references

Interacting Drugs Toxicity Mechanism Reference
Gabapentin Anxiety Significant adverse effects may occur through the interaction of the antidepressants with other receptors believed not to be related to the therapeutic action@ most importantly the muscarinic acetylcholine receptor (M)@ the histamine-1 (H1) receptor and the alpha-1 (alpha 1) adrenergic receptor@leading to anxiety [ ADR Type 2 ] Cell-mediated side effects of psychopharmacological treatment
Gabapentin Nausea Significant adverse effects may occur through the interaction of the antidepressants with other receptors believed not to be related to the therapeutic action@ most importantly the muscarinic acetylcholine receptor (M)@ the histamine-1 (H1) receptor and the alpha-1 (alpha 1) adrenergic receptor@leading to nausea. [ ADR Type 2 ] Cell-mediated side effects of psychopharmacological treatment
Gabapentin Sleep Disturbances Significant adverse effects may occur through the interaction of the antidepressants with other receptors believed not to be related to the therapeutic action@ most importantly the muscarinic acetylcholine receptor (M)@ the histamine-1 (H1) receptor and the alpha-1 (alpha 1) adrenergic receptor@leading to sleep disturbances. [ ADR Type 2 ] Cell-mediated side effects of psychopharmacological treatment
Masoprocol Dry Mouth Not Available Large-scale prediction and testing of drug activity on side-effect targets
Pirenzepine Impair Working Memory Blockade of hippocampal M2 muscarinic receptors impairs working memory performance of rats [ ADR Type 1 ] Blockade of hippocampal M1 muscarinic receptors impairs working memory performance of rats
Ritodrine Hyperhidrosis Not Available Large-scale prediction and testing of drug activity on side-effect targets
Ritodrine Mental Disorder Not Available Large-scale prediction and testing of drug activity on side-effect targets

This panel provides information on drug category

Toxicity Source
Anticholinergic Syndrome Large-scale prediction and testing of drug activity on side-effect targets
Constipation Large-scale prediction and testing of drug activity on side-effect targets
Cycloplegia Large-scale prediction and testing of drug activity on side-effect targets
Diabetic Eye Disease Large-scale prediction and testing of drug activity on side-effect targets
Dry Mouth Large-scale prediction and testing of drug activity on side-effect targets
Dry Skin Large-scale prediction and testing of drug activity on side-effect targets
Dysphagia Large-scale prediction and testing of drug activity on side-effect targets
Dysuria Large-scale prediction and testing of drug activity on side-effect targets
Extrapyramidal Disorder Large-scale prediction and testing of drug activity on side-effect targets
Hyperpyrexia Large-scale prediction and testing of drug activity on side-effect targets
Hyperthermia Large-scale prediction and testing of drug activity on side-effect targets
Hyperventilation Large-scale prediction and testing of drug activity on side-effect targets
Hypohidrosis Large-scale prediction and testing of drug activity on side-effect targets
Intraocular Pressure Increased Large-scale prediction and testing of drug activity on side-effect targets
Mydriasis Large-scale prediction and testing of drug activity on side-effect targets
Neuroleptic Malignant Syndrome Large-scale prediction and testing of drug activity on side-effect targets
Photophobia Large-scale prediction and testing of drug activity on side-effect targets
Suppressed Lactation Large-scale prediction and testing of drug activity on side-effect targets
Tachycardia Large-scale prediction and testing of drug activity on side-effect targets
Urinary Retention Large-scale prediction and testing of drug activity on side-effect targets
Vision Blurred Large-scale prediction and testing of drug activity on side-effect targets

InAADR: Drug-Protein-ADRs database