| Protein Name: | Multidrug resistance-associated protein (P33527) |
|---|---|
| Gene Name: | ABCC1 |
| Description: | Multidrug resistance-associated protein 1 (ATP-binding cassette sub- family C member 1) (Leukotriene C(4) transporter) (LTC4 transporter) |
| PDB ID: | 2CBZ |
| Protein Family: | |
| Protein Category: | Transporters |
| Protein Name: | Multidrug resistance-associated protein (Q92887) |
| Gene Name: | ABCC2 |
| Description: | Canalicular multispecific organic anion transporter 1 (ATP-binding cassette sub-family C member 2) (Multidrug resistance-associated protein 2) (Canalicular multidrug resistance protein) |
| PDB ID: | |
| Protein Family: | |
| Protein Category: | Transporters |
This panel provides drug-protein interaction and their ADRs along with references
| Interacting Drugs | Toxicity | Mechanism | Reference |
|---|---|---|---|
| Ivermectin | Cytotoxicity | Ivermectin efficiently inhibites the fully activated ATPase of MRP2 with respective IC50 values of 18 ? 5 ?M@ thus increases the Cytotoxicity of verapamil [ ADR Type 4 ] | P-glycoprotein and multidrug resistance-associated protein mediate specific patterns of multidrug resistance in malignant glioma cell lines, but not in primary glioma cells |
This panel provides information on drug category
| Toxicity | Source |
|---|