| Protein Name: | Mitogen-activated protein kinase (P45983) |
|---|---|
| Gene Name: | Not Available |
| Description: | Mitogen-activated protein kinase 8 (EC 2 7 11 24) (Stress-activated protein kinase JNK1) (c-Jun N-terminal kinase 1) (JNK-46) |
| PDB ID: | 1UKH |
| Protein Family: | |
| Protein Category: | Enzyme |
This panel provides drug-protein interaction and their ADRs along with references
| Interacting Drugs | Toxicity | Mechanism | Reference |
|---|---|---|---|
| Cisplatin | Apoptosis | Activation of JNK and cell death by cisplatin is mediated by the MEKK1/SEK1 cascade@ since expression of dominant negative expression vectors of these kinases blocked both processes;The increase in JNK activity was necessary for cisplatin-mediated apoptosis but it was dispensable for adriamycin-induced cell death. [ ADR Type 2 ] | Lack of c-Jun activity increases survival to cisplatin |
| Etoposide | Apoptosis | Induction of apoptotic cell death and DNA damage by treatment of U937 cells with etoposide (100 microM) was associated with a modest@ but sustained@ recruitment of the mitogen-activated protein kinases p42-extracellular signal receptor-activated kinase (ERK)1 and p44-extracellular signal receptor-activated kinase 2. [ ADR Type 2 ] | Evidence that the apoptotic actions of etoposide are independent of c-Jun/activating protein-1-mediated transregulation |
| Haloperidol | Neuronal Apoptosis | The c-Jun-NH(2)-terminal protein kinase and p38 mitogen-activated protein kinase were activated within 1 h and were sustained over the next 3 h following exposure of cortical neurons to haloperidol@which leads to Haloperidol-induced neuronal apoptosis [ ADR Type 2 ] | Haloperidol-induced neuronal apoptosis: role of p38 and c-Jun-NH(2)-terminal protein kinase |
This panel provides information on drug category
| Toxicity | Source |
|---|