| Protein Name: | Cytochrome P450 reductase (P16435) |
|---|---|
| Gene Name: | POR |
| Description: | NADPH--cytochrome P450 reductase (EC 1 6 2 4) (CPR) (P450R) |
| PDB ID: | 1B1C |
| Protein Family: | |
| Protein Category: | Enzyme |
This panel provides drug-protein interaction and their ADRs along with references
| Interacting Drugs | Toxicity | Mechanism | Reference |
|---|---|---|---|
| Indomethacin | Selective Effect Of A P-Chlorophenyl Moiety | Indomethacin in vitro also caused a loss of cytochrome b5@ NADH-cytochrome b5 reductase@ NADPH-cytochrome c reductase and Epoxide hydrolase activities@ but an activation of UDP-glucuronyltransferase@which leads to selective effect of a p-chlorophenyl moiety. [ ADR Type 1 ] | Denaturation of cytochrome P-450 by indomethacin and other non-steroidal anti-inflammatory drugs: evidence for a surfactant mechanism and a selective effect of a p-chlorophenyl moiety |
| RB90740(fused pyrazine mono-N-oxide bioreductive drugs) | Hypoxia | Relationship between the intracellular levels of P450 reductase and cytochrome b5 reductase and the hypoxic toxicity of RB90740 [ ADR Type 1 ] | Enzymology of the reduction of the novel fused pyrazine mono-n-oxide bioreductive drug, RB90740 roles for P450 reductase and cytochrome b5 reductase |
This panel provides information on drug category
| Toxicity | Source |
|---|