| Protein Name: | Cytochrome P450 2B6 (P20813) |
|---|---|
| Gene Name: | CYP2B6 |
| Description: | Cytochrome P450 2B6 (EC 1 14 14 1) (CYPIIB6) (P450 IIB1) |
| PDB ID: | 3IBD |
| Protein Family: | |
| Protein Category: | Enzyme |
This panel provides drug-protein interaction and their ADRs along with references
| Interacting Drugs | Toxicity | Mechanism | Reference |
|---|---|---|---|
| Methyltestosterone | Dangerous Side Effects | Estratest inhibits CYP2B6 activity@ as a result it increases the level of mephenytoin in blood and causes dangerous side effects [ ADR Type 4 ] | Inhibition of cytochrome P450 2B6 activity by hormone replacement therapy and oral contraceptive as measured by bupropion hydroxylation |
| Phenytoin | Bradycardia | In vitro studies indicate that bupropion is primarily metabolized to hydroxybupropion by the cytochrome P450IIB6 (CYP2B6) isoenzyme Therefore@ the potential exists for a drug interaction between ZYBAN and drugs that affect the CYP2B6 isoenzyme (e g @ orphenadrine and cyclophosphamide) [ ADR Type 4 ] | Retrospective evaluation of tiagabine overdose |
| S-mephenytoin | Dangerous Side Effects | Estradiol inhibits CYP2B6 activity@ as a result it increases the level of mephenytoin in blood and causes dangerous side effects [ ADR Type 4 ] | Oxidation of quinidine by human liver cytochrome P-450 |
This panel provides information on drug category
| Toxicity | Source |
|---|