InAADR

Protein Information

Protein Name: Caspase-8 (Q14790)
Gene Name: CASP8
Description: Caspase-8 precursor (EC 3 4 22 -) (CASP-8) (ICE-like apoptotic protease 5) (MORT1-associated CED-3 homolog) (MACH) (FADD-homoloGOus ICE/CED-3-like protease) (FADD-like ICE) (FLICE) (Apoptotic cysteine protease) (Apoptotic protease Mch-5) (CAP4) [Contains:
PDB ID: 1F9E
Protein Family:
Protein Category: Enzyme

This panel provides drug-protein interaction and their ADRs along with references

Interacting Drugs Toxicity Mechanism Reference
Cisplatin Apoptosis Cisplatin (CDDP) specifically induces apoptosis via sequential activation of caspase-8@ -3 and -6 in osteosarcoma. [ ADR Type 2 ] Cisplatin (CDDP) specifically induces apoptosis via sequential activation of caspase-8, -3 and -6 in osteosarcoma
Etoposide Apoptosis Association of active caspase 8 with the mitochondrial membrane during apoptosis: potential roles in cleaving BAP31 and caspase 3 and mediating mitochondrion-endoplasmic reticulum cross talk in etoposide-induced cell death [ ADR Type 2 ] Association of active caspase 8 with the mitochondrial membrane during apoptosis: potential roles in cleaving BAP31 and caspase 3 and mediating mitochondrion-endoplasmic reticulum cross talk
Etoposide Cell Death Caspase 8 activation plays a causal role in VP16-induced caspase 3 activation and cell death. [ ADR Type 2 ] Association of active caspase 8 with the mitochondrial membrane during apoptosis: potential roles in cleaving BAP31 and caspase 3 and mediating mitochondrion-endoplasmic reticulum cross talk
Lovastatin Apoptosis Consistent with initiation of apoptosis@ cellular caspase-8@ caspase-9 and caspase-3 activities were elevated in lovastatin-treated cells. [ ADR Type 2 ] Lovastatin inhibits tumor growth and lung metastasis in mouse mammary carcinoma model: a p53-independent mitochondrial-mediated apoptotic mechanism

This panel provides information on drug category

Toxicity Source

InAADR: Drug-Protein-ADRs database