InAADR: Drug-Protein-ADRs database

InAADR

Enter Protein Name or Uniprot ID:

Protein Information

Protein Name:	Carbonic anhydrase 12 precursor (O43570)
Gene Name:	CA12
Description:
PDB ID:	1JCZ
Protein Family:	PF00194, PS00162
Protein Category:	Enzyme

Drug-Protein Interaction
Adverse Drug Reactions

This panel provides drug-protein interaction and their ADRs along with references

Interacting Drugs	Toxicity	Mechanism	Reference
Acetazolamide	Acidosis Impair Parathyroid Hormone-Mediated Bone Buffering	Because parathyroid hormone, 1,25-dihydroxyvitamin D and carbonic anhydrase are thought to be involved in bone buffering,the marked acidosis seen in haemodialysis patients treated with acetazolamide may be due to impaired parathyroid hormone-mediated bone buffering. [ ADR Type 2 ]	Severe metabolic acidosis and disturbances of calcium metabolism induced by acetazolamide in patients on haemodialysis
Acetazolamide	Increase In Blood Flow	The inhibition of carbonic anhydrase activity by acetazolamide (AZ), which decreases the rate of CO2 conversion to HCO3-, causes the retention of CO2 in tissues and organs, and thus increases BF in specific organs,which lead to acetazolamide-induced increase in blood flow to rabbit organs. [ ADR Type 1 ]	Acetazolamide-induced increase in blood flow to rabbit organs is confirmed using colored microspheres Heart Vessels

This panel provides information on drug category

Toxicity	Source
Aplastic Anaemia	Large-scale prediction and testing of drug activity on side-effect targets
Electrolyte Imbalance	Large-scale prediction and testing of drug activity on side-effect targets
Glycosuria	Large-scale prediction and testing of drug activity on side-effect targets
Gout	Large-scale prediction and testing of drug activity on side-effect targets
Haemolytic Anaemia	Large-scale prediction and testing of drug activity on side-effect targets
Haemorrhagic Diathesis	Large-scale prediction and testing of drug activity on side-effect targets
Hyperuricaemia	Large-scale prediction and testing of drug activity on side-effect targets
Hypokalaemia	Large-scale prediction and testing of drug activity on side-effect targets
Pancreatitis	Large-scale prediction and testing of drug activity on side-effect targets
Photosensitivity Reaction	Large-scale prediction and testing of drug activity on side-effect targets
Purine Metabolism Disorder	Large-scale prediction and testing of drug activity on side-effect targets
Thrombocytopenia	Large-scale prediction and testing of drug activity on side-effect targets

InAADR: Drug-Protein-ADRs database