InAADR

Protein Information

Protein Name: Alpha-1A adrenergic receptor (P35348)
Gene Name: ADRA1A
Description:
PDB ID:
Protein Family: PF00001, PS00237
Protein Category: Membrane Receptors

This panel provides drug-protein interaction and their ADRs along with references

Interacting Drugs Toxicity Mechanism Reference
Exemestane Depression Not Available Large-scale prediction and testing of drug activity on side-effect targets
Gabapentin Anxiety Significant adverse effects may occur through the interaction of the antidepressants with other receptors believed not to be related to the therapeutic action@ most importantly the muscarinic acetylcholine receptor (M)@ the histamine-1 (H1) receptor and the alpha-1 (alpha 1) adrenergic receptor@leading to anxiety. [ ADR Type 2 ] Cell-mediated side effects of psychopharmacological treatment
Gabapentin Nausea Significant adverse effects may occur through the interaction of the antidepressants with other receptors believed not to be related to the therapeutic action@ most importantly the muscarinic acetylcholine receptor (M)@ the histamine-1 (H1) receptor and the alpha-1 (alpha 1) adrenergic receptor@leading to nausea. [ ADR Type 2 ] Cell-mediated side effects of psychopharmacological treatment
Gabapentin Sleep Disturbances Significant adverse effects may occur through the interaction of the antidepressants with other receptors believed not to be related to the therapeutic action@ most importantly the muscarinic acetylcholine receptor (M)@ the histamine-1 (H1) receptor and the alpha-1 (alpha 1) adrenergic receptor@leading to sleep disturbances. [ ADR Type 2 ] Cell-mediated side effects of psychopharmacological treatment
Medroxyprogesterone Amenorrhoea Not Available Large-scale prediction and testing of drug activity on side-effect targets
Medroxyprogesterone Cushingoid Not Available Large-scale prediction and testing of drug activity on side-effect targets
Medrysone Electrolyte Imbalance Not Available Large-scale prediction and testing of drug activity on side-effect targets
Medrysone Menstrual Disorder Not Available Large-scale prediction and testing of drug activity on side-effect targets
Sertraline Ataxia Not Available Large-scale prediction and testing of drug activity on side-effect targets

This panel provides information on drug category

Toxicity Source
Anxiety Large-scale prediction and testing of drug activity on side-effect targets
Bradycardia Large-scale prediction and testing of drug activity on side-effect targets
Carbohydrate Metabolism Disorder Large-scale prediction and testing of drug activity on side-effect targets
Cerebral Haemorrhage Large-scale prediction and testing of drug activity on side-effect targets
Dyskinesia Large-scale prediction and testing of drug activity on side-effect targets
Dysuria Large-scale prediction and testing of drug activity on side-effect targets
Ejaculation Disorder Large-scale prediction and testing of drug activity on side-effect targets
Fear Large-scale prediction and testing of drug activity on side-effect targets
Gangrene Large-scale prediction and testing of drug activity on side-effect targets
Gestational Hypertension Large-scale prediction and testing of drug activity on side-effect targets
Hyperhidrosis Large-scale prediction and testing of drug activity on side-effect targets
Hypertension Large-scale prediction and testing of drug activity on side-effect targets
Insomnia Large-scale prediction and testing of drug activity on side-effect targets
Intranasal Paraesthesia Large-scale prediction and testing of drug activity on side-effect targets
Irritability Large-scale prediction and testing of drug activity on side-effect targets
Nasal Congestion Large-scale prediction and testing of drug activity on side-effect targets
Nasal Discomfort Large-scale prediction and testing of drug activity on side-effect targets
Nasal Dryness Large-scale prediction and testing of drug activity on side-effect targets
Nervous System Disorder Large-scale prediction and testing of drug activity on side-effect targets
Orthostatic Hypotension Large-scale prediction and testing of drug activity on side-effect targets
Pallor Large-scale prediction and testing of drug activity on side-effect targets
Palpitations Large-scale prediction and testing of drug activity on side-effect targets
Psychotic Disorder Large-scale prediction and testing of drug activity on side-effect targets
Pulmonary Oedema Large-scale prediction and testing of drug activity on side-effect targets
Restlessness Large-scale prediction and testing of drug activity on side-effect targets
Sleep Disorder Large-scale prediction and testing of drug activity on side-effect targets
Sneezing Large-scale prediction and testing of drug activity on side-effect targets
Sudden Death Large-scale prediction and testing of drug activity on side-effect targets
Tachycardia Large-scale prediction and testing of drug activity on side-effect targets
Vasoconstriction Large-scale prediction and testing of drug activity on side-effect targets
Ventricular Arrhythmia Large-scale prediction and testing of drug activity on side-effect targets

InAADR: Drug-Protein-ADRs database