| Protein Name: | Adenosine A1 receptor (P30542) |
|---|---|
| Gene Name: | ADORA1 |
| Description: | Adenosine A1 receptor |
| PDB ID: | |
| Protein Family: | |
| Protein Category: | Membrane Receptors |
This panel provides drug-protein interaction and their ADRs along with references
| Interacting Drugs | Toxicity | Mechanism | Reference |
|---|---|---|---|
| Baclofen | Threshold Normalization | In SCS responding rats@ combination of a selective GABA(B) and an adenosine A1 receptor antaGOnist (CGP 55845@ CPT) in low@ ineffective doses abolished the SCS-induced threshold normalization [ ADR Type 1 ] | Effect of spinal cord stimulation on tactile hypersensitivity in mononeuropathic rats is potentiated by simultaneous GABA(B) and adenosine receptor activation |
| Interferon gamma-1b | Analgesia | Formalin-induced pain and mu-opioid receptor density in brain and spinal cord are modulated by A1 and A2a adenosine aGOnists in mice@which lead to dose-dependent analgesia [ ADR Type 1 ] | Formalin-induced pain and mu-opioid receptor density in brain and spinal cord are modulated by A1 and A2a adenosine agonists in mice |
This panel provides information on drug category
| Toxicity | Source |
|---|