InAADR

Protein Information

Protein Name: 5-hydroxytryptamine receptor 2A (P28223)
Gene Name: HTR2A
Description:
PDB ID:
Protein Family: PF00001, PS00237
Protein Category: Membrane Receptors

This panel provides drug-protein interaction and their ADRs along with references

Interacting Drugs Toxicity Mechanism Reference
Gabapentin Anxiety Adverse effects may@ however@ occur through the stimulation of different serotonin receptor subtypes (5-HT2A@ 5-HT2B@ and 5-HT3)@ leading to anxiety [ ADR Type 2 ] Cell-mediated side effects of psychopharmacological treatment
Gabapentin Nausea Adverse effects may@ however@ occur through the stimulation of different serotonin receptor subtypes (5-HT2A@ 5-HT2B@ and 5-HT3)@ leading to nausea. [ ADR Type 2 ] Cell-mediated side effects of psychopharmacological treatment
Gabapentin Sleep Disturbances Adverse effects may@ however@ occur through the stimulation of different serotonin receptor subtypes (5-HT2A@ 5-HT2B@ and 5-HT3)@ leading to sleep disturbances [ ADR Type 2 ] Cell-mediated side effects of psychopharmacological treatment
Tamsulosin Palpitations Not Available Large-scale prediction and testing of drug activity on side-effect targets

This panel provides information on drug category

Toxicity Source
Akathisia Large-scale prediction and testing of drug activity on side-effect targets
Anticholinergic Syndrome Large-scale prediction and testing of drug activity on side-effect targets
Anxiety Cortical 5-HT2A receptor signaling modulates anxiety-like behaviors in mice
Bipolar Disorder A European multicenter association study of HTR2A receptor polymorphism in bipolar affective disorder
Corneal Pigmentation Large-scale prediction and testing of drug activity on side-effect targets
Dermatitis Allergic Large-scale prediction and testing of drug activity on side-effect targets
Dry Mouth Large-scale prediction and testing of drug activity on side-effect targets
Dystonia Large-scale prediction and testing of drug activity on side-effect targets
Ejaculation Disorder Large-scale prediction and testing of drug activity on side-effect targets
Electrocardiogram Change Large-scale prediction and testing of drug activity on side-effect targets
Erectile Dysfunction Large-scale prediction and testing of drug activity on side-effect targets
Extrapyramidal Disorder Large-scale prediction and testing of drug activity on side-effect targets
Fibrocystic Breast Disease Large-scale prediction and testing of drug activity on side-effect targets
Galactorrhoea Large-scale prediction and testing of drug activity on side-effect targets
Gynaecomastia Large-scale prediction and testing of drug activity on side-effect targets
Hypercholesterolaemia Large-scale prediction and testing of drug activity on side-effect targets
Hyperprolactinaemia Large-scale prediction and testing of drug activity on side-effect targets
Hyperthermia Large-scale prediction and testing of drug activity on side-effect targets
Insomnia Large-scale prediction and testing of drug activity on side-effect targets
Lenticular Opacities Large-scale prediction and testing of drug activity on side-effect targets
Lipid Metabolism Disorder Large-scale prediction and testing of drug activity on side-effect targets
Mania Large-scale prediction and testing of drug activity on side-effect targets
Miosis Large-scale prediction and testing of drug activity on side-effect targets
Mydriasis Large-scale prediction and testing of drug activity on side-effect targets
Nasal Congestion Large-scale prediction and testing of drug activity on side-effect targets
Neuroleptic Malignant Syndrome Large-scale prediction and testing of drug activity on side-effect targets
Obsessive Compulsive Disorder The role of 5-HT2A and 5-HT2C receptors in the signal attenuation rat model of obsessive-compulsive disorder
Orthostatic Hypotension Large-scale prediction and testing of drug activity on side-effect targets
Parkinsonism Large-scale prediction and testing of drug activity on side-effect targets
Schizophrenia Lack of allelic association between 102T/C polymorphism of serotonin receptor type 2A gene and schizophrenia in Chinese
Tachycardia Large-scale prediction and testing of drug activity on side-effect targets
Tardive Dyskinesia Large-scale prediction and testing of drug activity on side-effect targets
Tremor Acute immobilization stress reduces (+/-)DOI-induced 5-HT2A receptor-mediated head shakes in rats
Weight Increased Large-scale prediction and testing of drug activity on side-effect targets

InAADR: Drug-Protein-ADRs database