InAADR

Drug Information

Drug Name: hydrocodone (125-29-1)
PubChem ID: 5284569
SMILES: CN1CC[C@]23[C@@H]4[C@H]1CC5=C2C(=C(C=C5)OC)O[C@H]3C(=O)CC4
InchiKey: LLPOLZWFYMWNKH-CMKMFDCUSA-N
Therapeutic Category: Analgesics, Antitussive Agents, Central Nervous System Agents, Central Nervous System Depressants, Narcotics, Peripheral Nervous System Agents, Respiratory System Agents, Sensory System Agents

Computed Drug Properties

Molecular Weight (dalton): 299.37
LogP: 1.9333
Ring Count: 1
Hydrogen Bond Acceptor Count: 4
Hydrogen Bond Donor Count: 0
Total Polar Surface Area: 38.77

This panel provides information on interacting drugs and their ADRs along with references

Interacting drug Toxicity Interaction Type Mechanism Reference

This panel provides drug-protein interaction and their ADRs along with references

Toxicity Interacting Protein Mechanism Reference

This panel provides drug-food interactions and their ADRs along with references

Food Toxicity Reference

This panel provides information on metabolites and their ADRs along with references

Metabolite Toxicity Place of Metabolism Mechanism Reference

This panel provides information on drug category

Toxicity Source
Abasia MetaADEDB
Abdominal Abscess MetaADEDB
Abdominal Adhesions MetaADEDB
Abdominal Discomfort MetaADEDB
Abdominal Distension MetaADEDB
Abdominal Hernia MetaADEDB
Abdominal Pain MetaADEDB
Abdominal Pain MetaADEDB
Abdominal Tenderness MetaADEDB
Abnormal Behaviour MetaADEDB
Abnormal Ecg MetaADEDB
Abnormal Lfts MetaADEDB
Abnormal Movements MetaADEDB
Abnormal Vision MetaADEDB
Abortion MetaADEDB
Abscess Jaw MetaADEDB
Accidental Exposure MetaADEDB
Accidental Overdose MetaADEDB
Aching Joints MetaADEDB
Aching Muscles MetaADEDB
Acid Reflux MetaADEDB
Acquired Protein S Deficiency MetaADEDB
Actinomycosis MetaADEDB
Acute Brain Syndrome MetaADEDB
Acute Endocarditis MetaADEDB
Acute Kidney Failure MetaADEDB
Acute Pancreatitis MetaADEDB
Acute Respiratory Failure MetaADEDB
Adenocarcinoma MetaADEDB
Adenopathy MetaADEDB
Adrenal Gland Cancer Metastatic MetaADEDB
Adrenal Insufficiency MetaADEDB
Adrenal Neoplasm MetaADEDB
Afib MetaADEDB
Ageusia MetaADEDB
Alanine Aminotransferase MetaADEDB
Alanine Aminotransferase Abnormal MetaADEDB
Alopecia MetaADEDB
Alpha Haemolytic Streptococcal Infection MetaADEDB
Amentia MetaADEDB
Amnesia MetaADEDB
Anaemia MetaADEDB
Aneurysm MetaADEDB
Anger MetaADEDB
Angina MetaADEDB
Angina Unstable MetaADEDB
Anhedonia MetaADEDB
Animal Scratch MetaADEDB
Anorexia MetaADEDB
Anosmia MetaADEDB
Anxiety MetaADEDB
Aortic Regurgitation MetaADEDB
Aortic Stenosis MetaADEDB
Aortic Valve Repair MetaADEDB
Aortic Valve Replacement MetaADEDB
Aphonia MetaADEDB
Apoplexy MetaADEDB
Application Site Burn MetaADEDB
Application Site Rash MetaADEDB
Application Site Reaction MetaADEDB
Arrhythmia MetaADEDB
Arrhythmia Supraventricular MetaADEDB
Arterial Pressure Nos Decreased MetaADEDB
Arterial Thrombosis MetaADEDB
Arteriosclerosis MetaADEDB
Arteriosclerotic Heart Disease MetaADEDB
Arteriospasm Coronary MetaADEDB
Arthritis MetaADEDB
Arthropathy MetaADEDB
Asbestosis MetaADEDB
Ascites MetaADEDB
Aseptic Necrosis Bone MetaADEDB
Aspartate Aminotransferase MetaADEDB
Aspartate Aminotransferase Abnormal MetaADEDB
Aspiration Pleural Cavity MetaADEDB
Asthenia MetaADEDB
Asystole MetaADEDB
Atelectasis MetaADEDB
Atrial Ectopic Beats MetaADEDB
Atrial Septal Defect MetaADEDB
Atrial Tachycardia MetaADEDB
Atrioventricular Block Complete MetaADEDB
Atrophy MetaADEDB
Attempted Suicide MetaADEDB
Attention Deficit/Hyperactivity Disorder MetaADEDB
Aura MetaADEDB
Back Ache MetaADEDB
Back Disorder MetaADEDB
Back Injury MetaADEDB
Bacterial Toxaemia MetaADEDB
Benign Bone Neoplasm MetaADEDB
Bile Duct Stone MetaADEDB
Biliary Sepsis MetaADEDB
Biopsy Colon MetaADEDB
Bipolar Disorder MetaADEDB
Bladder Disorder MetaADEDB
Bladder Inflammation MetaADEDB
Bleb MetaADEDB
Bleeding Gums MetaADEDB
Bleeding Vaginal MetaADEDB
Blood Albumin MetaADEDB
Blood Albumin Abnormal MetaADEDB
Blood Albumin Decreased MetaADEDB
Blood Alkaline Phosphatase MetaADEDB
Blood Alkaline Phosphatase Increased MetaADEDB
Blood Bilirubin MetaADEDB
Blood Calcium MetaADEDB
Blood Cholesterol MetaADEDB
Blood Creatinine MetaADEDB
Blood Creatinine Decreased MetaADEDB
Blood In Urine MetaADEDB
Blood Magnesium MetaADEDB
Blood Magnesium Decreased MetaADEDB
Blood Ph Decreased MetaADEDB
Blood Phosphorus MetaADEDB
Blood Potassium MetaADEDB
Blood Potassium Decreased MetaADEDB
Blood Pressure Immeasurable MetaADEDB
Blood Sodium Abnormal MetaADEDB
Blood Testosterone Decreased MetaADEDB
Body Temperature MetaADEDB
Body Temperature Increased MetaADEDB
Body Tinea MetaADEDB
Bone Cancer Metastatic MetaADEDB
Bone Density Decreased MetaADEDB
Bone Disorder MetaADEDB
Bone Marrow Failure MetaADEDB
Bone Neoplasm Malignant MetaADEDB
Bowel Movement Irregularity MetaADEDB
Bradypnoea MetaADEDB
Brain Death MetaADEDB
Brain Herniation MetaADEDB
Brain Mass MetaADEDB
Brain Oedema MetaADEDB
Breast Lump MetaADEDB
Breast Neoplasm MetaADEDB
Bronchitis MetaADEDB
Bronchoscopy MetaADEDB
Bulging MetaADEDB
Burn Oesophageal MetaADEDB
Burning Sensation MetaADEDB
Cancer MetaADEDB
Cardiac Ablation MetaADEDB
Cardiac Decompensation MetaADEDB
Cardiac Disease MetaADEDB
Cardiac Enlargement MetaADEDB
Cardiac Enzymes Increased MetaADEDB
Cardiac Operation MetaADEDB
Cardiac Valve Vegetation MetaADEDB
Cardio-Respiratory Arrest MetaADEDB
Cardioactive Drug Level Increased MetaADEDB
Carotid Artery Occlusion MetaADEDB
Carotid Artery Stenosis MetaADEDB
Cataract MetaADEDB
Catheter Related Infection MetaADEDB
Catheter Site Haemorrhage MetaADEDB
Cellulitis MetaADEDB
Central Nervous System Lesion MetaADEDB
Central Venous Catheterisation MetaADEDB
Cerebellar Infarction MetaADEDB
Cerebral Vascular Disorder MetaADEDB
Cervical Cord Compression MetaADEDB
Cervicalgia MetaADEDB
Chest Pain MetaADEDB
Chest X-Ray Abnormal MetaADEDB
Chill MetaADEDB
Choking Sensation MetaADEDB
Cholecystitis Chronic MetaADEDB
Chondropathy MetaADEDB
Chromaturia MetaADEDB
Chronic Kidney Disease MetaADEDB
Chronic Obstructive Airway Disease MetaADEDB
Circumstance Or Information Capable Of Leading To Medication Error MetaADEDB
Clotting MetaADEDB
Cold Extremities MetaADEDB
Colitis Ischaemic MetaADEDB
Colitis Viral MetaADEDB
Colon Adenoma MetaADEDB
Colonic Polyp MetaADEDB
Confabulation MetaADEDB
Congenital Mitral Valve Incompetence MetaADEDB
Congenital Tricuspid Valve Incompetence MetaADEDB
Conjunctivitis Allergic MetaADEDB
Constipated MetaADEDB
Coronary Artery Bypass MetaADEDB
Cough MetaADEDB
Coughing Blood MetaADEDB
Csf Protein MetaADEDB
Culture Positive MetaADEDB
Culture Wound Positive MetaADEDB
Cyst MetaADEDB
Cystitis Interstitial MetaADEDB
Death MetaADEDB
Debridement MetaADEDB
Decubitus Ulcer MetaADEDB
Defaecation Urgency MetaADEDB
Deglutition Disorder MetaADEDB
Dehydration MetaADEDB
Demyelination MetaADEDB
Dental Abscess MetaADEDB
Dental Caries MetaADEDB
Dental Fistula MetaADEDB
Dental Necrosis MetaADEDB
Dental Operation MetaADEDB
Dental Pain MetaADEDB
Device Leakage MetaADEDB
Diabetes MetaADEDB
Diabetes Mellitus Insulin-Dependent MetaADEDB
Diabetes Mellitus Non-Insulin-Dependent MetaADEDB
Diabetic Acidosis MetaADEDB
Diabetic Hyperosmolar Coma MetaADEDB
Diabetic Neuropathy MetaADEDB
Diabetic Retinopathy MetaADEDB
Diarrhea MetaADEDB
Dislocation MetaADEDB
Disorder Lung MetaADEDB
Disorder Peripheral Vascular MetaADEDB
Disorder Renal MetaADEDB
Disseminated Intravascular Coagulation MetaADEDB
Diverticulum MetaADEDB
Dizziness MetaADEDB
Dizziness Exertional MetaADEDB
Documented Hypersensitivity To Administered Drug MetaADEDB
Drowning MetaADEDB
Drowsiness MetaADEDB
Drug Addict MetaADEDB
Drug Administered At Inappropriate Site MetaADEDB
Drug Dose Omission MetaADEDB
Drug Hypersensitivity MetaADEDB
Drug Ineffective MetaADEDB
Drug Prescribing Error MetaADEDB
Drug Screen MetaADEDB
Drug Screen Positive MetaADEDB
Drug Therapy Changed MetaADEDB
Drug Toxicity MetaADEDB
Drug Withdrawal Headache MetaADEDB
Dysgeusia MetaADEDB
Dyslipidaemia MetaADEDB
Dyspepsia MetaADEDB
Dysphonia MetaADEDB
Dyspnea Exertional MetaADEDB
Dysthymic Disorder MetaADEDB
Dysuria MetaADEDB
Ear Disorder MetaADEDB
Ear Infection MetaADEDB
Early Morning Awakening MetaADEDB
Early Satiety MetaADEDB
Eating Disorder MetaADEDB
Ecg Signs Of Ventricular Hypertrophy MetaADEDB
Echocardiogram Abnormal MetaADEDB
Economic Problem MetaADEDB
Edema Extremities MetaADEDB
Effusion MetaADEDB
Ejection Fraction Decreased MetaADEDB
Electrolyte Disorder MetaADEDB
Elevated Triglycerides MetaADEDB
Embolic Stroke MetaADEDB
Embolism Pulmonary MetaADEDB
Emesis MetaADEDB
Emotional Distress MetaADEDB
Encephalopathy MetaADEDB
Endocarditis MetaADEDB
Endotracheal Intubation MetaADEDB
Enterocolitis MetaADEDB
Epistaxis MetaADEDB
Erythema Migrans MetaADEDB
Eschar MetaADEDB
Esophageal Ulcer MetaADEDB
Expired Drug Administered MetaADEDB
Extrasystoles Ventricular MetaADEDB
Extremity Pain MetaADEDB
Eye Swelling MetaADEDB
Eyelid Diseases MetaADEDB
Factor V Leiden Mutation MetaADEDB
Failure To Thrive MetaADEDB
Fat Tissue Increased MetaADEDB
Fatigue MetaADEDB
Fatty Liver MetaADEDB
Feeling Abnormal MetaADEDB
Fibrin D Dimer MetaADEDB
Fibrinolysis Increased MetaADEDB
Fibromyalgia MetaADEDB
Flat Affect MetaADEDB
Fluid Overload MetaADEDB
Foaming At Mouth MetaADEDB
Formication MetaADEDB
Fungal Disease MetaADEDB
Gallbladder Cholesterolosis MetaADEDB
Gallbladder Non-Functioning MetaADEDB
Gangrene MetaADEDB
Gastric Disorder MetaADEDB
Gastrointestinal Bleed MetaADEDB
Gastrointestinal Disorder MetaADEDB
Gastrointestinal Obstruction MetaADEDB
Gastrointestinal Perforation MetaADEDB
Genital Burning Sensation MetaADEDB
Glaucoma MetaADEDB
Globulinuria MetaADEDB
Glucose Intolerance MetaADEDB
Gout MetaADEDB
Granulocytosis MetaADEDB
Groin Abscess MetaADEDB
Haemangioma Of Liver MetaADEDB
Haematochezia MetaADEDB
Haemorrhage Intracranial MetaADEDB
Haemorrhagic Anaemia MetaADEDB
Hallucinations MetaADEDB
Hearing Loss MetaADEDB
Heart Attack MetaADEDB
Heart Rate Increased MetaADEDB
Hemianopia MetaADEDB
Heparin-Induced Thrombocytopenia MetaADEDB
Hepatitis C MetaADEDB
Hernia MetaADEDB
Herpes Zoster MetaADEDB
Herpes Zoster Disseminated MetaADEDB
High Blood Pressure MetaADEDB
Histiocytosis Haematophagic MetaADEDB
Hyperemesis Gravidarum MetaADEDB
Hyperhidrosis MetaADEDB
Hyperlipaemia MetaADEDB
Hypertonia MetaADEDB
Hypoaesthesia MetaADEDB
Hypoaesthesia Facial MetaADEDB
Hypokalaemia MetaADEDB
Hypokinesia MetaADEDB
Hypomagnesaemia MetaADEDB
Hypomania MetaADEDB
Hypophosphataemia MetaADEDB
Hypovolaemia MetaADEDB
Immunosuppression MetaADEDB
Impaired Driving Ability MetaADEDB
Impaired Healing MetaADEDB
Impingement Syndrome MetaADEDB
Inappropriate Schedule Of Drug Administration MetaADEDB
Incoherent MetaADEDB
Infection MetaADEDB
Infection Upper Respiratory MetaADEDB
Infection Urinary Tract MetaADEDB
Injection Site Irritation MetaADEDB
Injection Site Pruritus MetaADEDB
Inspiratory Capacity Decreased MetaADEDB
Insulin-Requiring Type 2 Diabetes Mellitus MetaADEDB
Intention Tremor MetaADEDB
Intentional Drug Misuse MetaADEDB
Intertrigo MetaADEDB
Intervertebral Disc Degeneration MetaADEDB
Intervertebral Disc Disorder MetaADEDB
Intestinal Perforation MetaADEDB
Intestinal Polyp MetaADEDB
Intestinal Ulcer MetaADEDB
Intraocular Lens Implant MetaADEDB
Iron Deficiency Anaemia MetaADEDB
Irritable Bowel Syndrome MetaADEDB
Ischaemia MetaADEDB
Ischaemic Cardiomyopathy MetaADEDB
Ischaemic Stroke MetaADEDB
Joint Abscess MetaADEDB
Joint Effusion MetaADEDB
Joint Lock MetaADEDB
Kidney Failure MetaADEDB
Kidney Infection MetaADEDB
Laryngeal Inflammation MetaADEDB
Left Atrial Dilatation MetaADEDB
Left Ventricular Dysfunction MetaADEDB
Left Ventricular Hypertrophy MetaADEDB
Lethargy MetaADEDB
Leukopenia Neonatal MetaADEDB
Ligament Injury MetaADEDB
Localised Infection MetaADEDB
Loose Tooth MetaADEDB
Loss Of Employment MetaADEDB
Loss Of Proprioception MetaADEDB
Loss Of Weight MetaADEDB
Lumbar Radiculopathy MetaADEDB
Lung Cyst MetaADEDB
Lung Edema MetaADEDB
Lung Infection Pseudomonal MetaADEDB
Lung Infiltration MetaADEDB
Lung Neoplasm MetaADEDB
Lymphadenopathy Mediastinal MetaADEDB
Lymphocyte Count MetaADEDB
Lymphocytes Decreased MetaADEDB
Major Depression MetaADEDB
Malignant Neoplasm Progression MetaADEDB
Malnourished MetaADEDB
Mastication Disorder MetaADEDB
Megacolon MetaADEDB
Meningitis Bacterial MetaADEDB
Meniscus Lesion MetaADEDB
Mental Disorder MetaADEDB
Mental Status Changes MetaADEDB
Metabolic Acidosis MetaADEDB
Metabolic Encephalopathy MetaADEDB
Metastases To Central Nervous System MetaADEDB
Metastases To Liver MetaADEDB
Metastases To Spine MetaADEDB
Metastases To The Mediastinum MetaADEDB
Middle Ear Inflammation MetaADEDB
Migraine MetaADEDB
Mouth Pain MetaADEDB
Mouth Ulcer MetaADEDB
Mucosal Atrophy MetaADEDB
Mucosal Inflammation MetaADEDB
Multi-Organ Failure MetaADEDB
Multiple Drug Overdose MetaADEDB
Multiple Injuries MetaADEDB
Multiple Myeloma MetaADEDB
Multiple Sclerosis Relapse MetaADEDB
Musculoskeletal Chest Pain MetaADEDB
Musculoskeletal Discomfort MetaADEDB
Musculoskeletal Pain MetaADEDB
Musculoskeletal Stiffness MetaADEDB
Myelodysplasia MetaADEDB
Nausea MetaADEDB
Nephrectomy MetaADEDB
Nephrogenic Fibrosing Dermopathy MetaADEDB
Nephrolithiasis MetaADEDB
Nervous Tension MetaADEDB
Neumonia MetaADEDB
Neuralgia MetaADEDB
Neuropathy Peripheral MetaADEDB
Nightmare MetaADEDB
Non-Cardiac Chest Pain MetaADEDB
Nuclear Magnetic Resonance Imaging Brain Abnormal MetaADEDB
Nutritional Condition Abnormal MetaADEDB
Obstruction MetaADEDB
Occult Blood Positive MetaADEDB
Oesophageal Candidiasis MetaADEDB
Off Label Use MetaADEDB
Oral Discharge MetaADEDB
Oral Discomfort MetaADEDB
Oral Fungal Infection MetaADEDB
Oral Infection MetaADEDB
Oral Mucosal Exfoliation MetaADEDB
Oropharyngeal Pain MetaADEDB
Osteoarthritis MetaADEDB
Osteomyelitis MetaADEDB
Osteoporosis MetaADEDB
Ovarian Enlargement MetaADEDB
Overdose MetaADEDB
Oxygen Saturation Decreased MetaADEDB
Pain MetaADEDB
Pain In Throat MetaADEDB
Palmar-Plantar Erythrodysaesthesia Syndrome MetaADEDB
Palpitation MetaADEDB
Palsies MetaADEDB
Pancreatic Cancer MetaADEDB
Pancreatic Pseudocyst MetaADEDB
Pancreatitis MetaADEDB
Pancreatitis Chronic MetaADEDB
Papilloma Viral Infection MetaADEDB
Paraplegia MetaADEDB
Paronychia MetaADEDB
Pelvic Fluid Collection MetaADEDB
Performance Status Decreased MetaADEDB
Pericarditis MetaADEDB
Periodontitis MetaADEDB
Peripheral Ischaemia MetaADEDB
Peripheral Nerve Lesion MetaADEDB
Peritoneal Effusion MetaADEDB
Peritonitis MetaADEDB
Peyronie Disease MetaADEDB
Phantom Pain MetaADEDB
Phlebolith MetaADEDB
Phlebothrombosis MetaADEDB
Platelet Count MetaADEDB
Pleural Effusion MetaADEDB
Pleural Fibrosis MetaADEDB
Pleurisy MetaADEDB
Pneumonia Staphylococcal MetaADEDB
Polyp MetaADEDB
Poor Venous Access MetaADEDB
Post Procedural Haemorrhage MetaADEDB
Post Traumatic Stress Disorder MetaADEDB
Prostatomegaly MetaADEDB
Protein Total Decreased MetaADEDB
Prothrombin Time Prolonged MetaADEDB
Pseudomonas Infection MetaADEDB
Psychoses MetaADEDB
Psychosexual Disorder MetaADEDB
Pterygium MetaADEDB
Pulmonary Congestion MetaADEDB
Pulmonary Hypertension MetaADEDB
Pulmonary Valve Incompetence MetaADEDB
Pulpitis Dental MetaADEDB
Radiation Pneumonitis MetaADEDB
Rales MetaADEDB
Raynaud Phenomenon MetaADEDB
Rectal Polyp MetaADEDB
Renal Cancer Metastatic MetaADEDB
Respiratory Failure MetaADEDB
Respiratory Syncytial Virus Infection MetaADEDB
Rheumatoid Factor Increased MetaADEDB
Rhinorrhea MetaADEDB
Road Traffic Accident MetaADEDB
Scab MetaADEDB
Schamberg Disease MetaADEDB
Scleroderma MetaADEDB
Scotoma MetaADEDB
Sensation Of Heaviness MetaADEDB
Sensitivity Of Teeth MetaADEDB
Sepsis Syndrome MetaADEDB
Septic Shock MetaADEDB
Shoulder Pain MetaADEDB
Sickle Cell Anaemia With Crisis MetaADEDB
Sinus Disorder MetaADEDB
Sinusitis MetaADEDB
Skeletal Injury MetaADEDB
Skin Discolouration MetaADEDB
Skin Necrosis MetaADEDB
Sleep Apnea MetaADEDB
Sleep Disorder MetaADEDB
Soft Tissue Disorder MetaADEDB
Spinal Column Stenosis MetaADEDB
Spinal Compression Fracture MetaADEDB
Spinal Cord Compression MetaADEDB
Spinal Osteoarthritis MetaADEDB
Spinning Sensation MetaADEDB
Spondylolisthesis MetaADEDB
Staphylococcal Bacteraemia MetaADEDB
Staphylococcal Infection MetaADEDB
Stasis Dermatitis MetaADEDB
Stereotypy MetaADEDB
Still Disease Adult Onset MetaADEDB
Subdural Haematoma Evacuation MetaADEDB
Sudden Cardiac Death MetaADEDB
Superior Sagittal Sinus Thrombosis MetaADEDB
Surgery MetaADEDB
Synovial Cyst MetaADEDB
Tachyphrenia MetaADEDB
Tendon Disorder MetaADEDB
Tendon Pain MetaADEDB
Tendon Rupture MetaADEDB
Terminal State MetaADEDB
Therapeutic Response Decreased MetaADEDB
Thinking Abnormal MetaADEDB
Thoracic Vertebral Fracture MetaADEDB
Thrombosis In Device MetaADEDB
Thyroid Disease MetaADEDB
Tibia Fracture MetaADEDB
Tinea Pedis MetaADEDB
Tinnitus MetaADEDB
Tongue Biting MetaADEDB
Tooth Extraction MetaADEDB
Tooth Fracture MetaADEDB
Tooth Loss MetaADEDB
Tooth Resorption MetaADEDB
Total Lung Capacity Decreased MetaADEDB
Transient Ischaemic Attack MetaADEDB
Treatment Noncompliance MetaADEDB
Tumour Marker Increased MetaADEDB
Ulcer Haemorrhage MetaADEDB
Umbilical Hernia MetaADEDB
Unresponsive To Stimuli MetaADEDB
Urinary Tract Disorder MetaADEDB
Urine Analysis Abnormal MetaADEDB
Vaginal Stricture MetaADEDB
Vascular Headache MetaADEDB
Vascular Insufficiency MetaADEDB
Vena Cava Thrombosis MetaADEDB
Venous Insufficiency MetaADEDB
Vertebroplasty MetaADEDB
Vestibular Disorder MetaADEDB
Weight Bearing Difficulty MetaADEDB
Weight Gain MetaADEDB
Wheeze MetaADEDB
Withdrawal Syndrome MetaADEDB
Wound MetaADEDB
Wrong Technique In Drug Usage Process MetaADEDB

InAADR: Drug-Protein-ADRs database