InAADR

Drug Information

Drug Name: Sulindac (38194-50-2)
PubChem ID: 1548887
SMILES: CC1=C(C2=C(/C1=CC3=CC=C(C=C3)S(=O)C)C=CC(=C2)F)CC(=O)O
InchiKey: MLKXDPUZXIRXEP-MFOYZWKCSA-N
Therapeutic Category: Analgesics, Anti-Inflammatory Agents, Antineoplastic Agents, Antirheumatic Agents, Cyclooxygenase Inhibitors, Enzyme Inhibitors, Peripheral Nervous System Agents, Sensory System Agents

Computed Drug Properties

Molecular Weight (dalton): 356.418
LogP: 4.3655
Ring Count: 2
Hydrogen Bond Acceptor Count: 2
Hydrogen Bond Donor Count: 1
Total Polar Surface Area: 54.37

This panel provides information on interacting drugs and their ADRs along with references

Interacting drug Toxicity Interaction Type Mechanism Reference
Dimethyl sulfoxide (67-68-5) Neuropathy Additive Not Known Peripheral neuropathy after concomitant dimethyl sulfoxide use and sulindac therapy

This panel provides drug-protein interaction and their ADRs along with references

Toxicity Interacting Protein Mechanism Reference

This panel provides drug-food interactions and their ADRs along with references

Food Toxicity Reference

This panel provides information on metabolites and their ADRs along with references

Metabolite Toxicity Place of Metabolism Mechanism Reference

This panel provides information on drug category

Toxicity Source
Abdominal Discomfort MetaADEDB
Abdominal Neoplasm MetaADEDB
Abdominal Pain MetaADEDB
Abdominal Pain MetaADEDB
Abnormal Behaviour MetaADEDB
Abnormal Lfts MetaADEDB
Abnormal Mammogram MetaADEDB
Acarodermatitis MetaADEDB
Accidental Exposure MetaADEDB
Accommodation Disorder MetaADEDB
Aching Joints MetaADEDB
Acid Reflux MetaADEDB
Acromegaly MetaADEDB
Actinomycosis MetaADEDB
Acute Kidney Injury MetaADEDB
Acute Leukaemia ADReCS
Acute Pancreatitis MetaADEDB
Acute Psychosis ADReCS
Acute Respiratory Failure MetaADEDB
Acute Sinusitis MetaADEDB
Adenitis SIDER
Adenocarcinoma MetaADEDB
Adenoma MetaADEDB
Adenomatous Polyposis Coli MetaADEDB
Adenomatous Polyps MetaADEDB
Adenopathy MetaADEDB
Administration Site Pain MetaADEDB
Adverse Drug Reaction ADReCS
Ageusia ADReCS
Agranulocytosis ADReCS
Agraphia MetaADEDB
Alanine Aminotransferase Increased MetaADEDB
Albuminuria MetaADEDB
Allergic Cutaneous Angiitis SIDER
Allergic Rhinitis MetaADEDB
Allergic Sinusitis MetaADEDB
Alopecia ADReCS
Altered State Of Consciousness ADReCS
Alveoloplasty MetaADEDB
Anaemia ADReCS
Anaesthesia MetaADEDB
Anaphylactic Reaction ADReCS
Anaphylactic Shock ADReCS
Anaphylaxis MetaADEDB
Anemia Aplastic MetaADEDB
Anemia Hemolytic MetaADEDB
Anemia Hemolytic Autoimmune MetaADEDB
Angiitis MetaADEDB
Angina MetaADEDB
Angioedema ADReCS
Anhidrosis MetaADEDB
Anorexia ADReCS
Anxiety MetaADEDB
Aortic Stenosis MetaADEDB
Aplastic Anaemia ADReCS
Apoplexy MetaADEDB
Arrhythmia ADReCS
Arterial Occlusive Disease MetaADEDB
Arteriosclerotic Heart Disease MetaADEDB
Arthralgia ADReCS
Arthritis MetaADEDB
Arthritis Rheumatoid MetaADEDB
Ascites MetaADEDB
Aspartate Aminotransferase Increase MetaADEDB
Asthenia ADReCS
Atelectasis MetaADEDB
Autoimmune Hepatitis MetaADEDB
Autoimmune Thrombocytopenia MetaADEDB
Back Ache MetaADEDB
Bacterial Toxaemia MetaADEDB
Band Neutrophil Percentage Increased MetaADEDB
Bile Duct Stone MetaADEDB
Biliary Fibrosis MetaADEDB
Binge Eating MetaADEDB
Biopsy Breast Abnormal MetaADEDB
Birth Defect MetaADEDB
Bladder Catheterisation MetaADEDB
Bladder Inflammation MetaADEDB
Bleeding Vaginal SIDER
Blindness Unilateral MetaADEDB
Blood Alkaline Phosphatase Increased MetaADEDB
Blood Bilirubin Increased MetaADEDB
Blood Cholesterol MetaADEDB
Blood Ketone Body MetaADEDB
Blood Lactate Dehydrogenase Increased MetaADEDB
Blood Potassium Increased MetaADEDB
Blood Pressure Fluctuation ADReCS
Blood Urea Increased MetaADEDB
Blood Urine Present MetaADEDB
Bloody Discharge MetaADEDB
Blurred Vision MetaADEDB
Body Temperature Increased ADReCS
Bone Debridement MetaADEDB
Bone Inflammation MetaADEDB
Bone Lesion MetaADEDB
Bone Marrow Depression SIDER
Bone Marrow Failure ADReCS
Bone Pain MetaADEDB
Bowen Disease MetaADEDB
Bradypnoea MetaADEDB
Brain Death MetaADEDB
Brain Diseases MetaADEDB
Brain Herniation MetaADEDB
Brain Oedema MetaADEDB
Breakthrough Bleeding MetaADEDB
Breast Atrophy MetaADEDB
Breast Lump MetaADEDB
Breast Lump Removal MetaADEDB
Breast Neoplasms MetaADEDB
Bronchitis Viral MetaADEDB
Bronchoalveolar Lavage MetaADEDB
Bronchospasm ADReCS
Bruise MetaADEDB
Bundle Branch Block MetaADEDB
Burn Oesophageal MetaADEDB
Calcium Metabolism Disorder MetaADEDB
Calculus Of Kidney SIDER
Candida Infection MetaADEDB
Carcinoma Of Prostate MetaADEDB
Cardiac Decompensation MetaADEDB
Cardiac Enlargement MetaADEDB
Cardiac Enzymes Increased MetaADEDB
Cardiac Failure ADReCS
Cardiac Failure Congestive ADReCS
Cardiomyopathy MetaADEDB
Cardiovascular Disorder ADReCS
Carotid Artery Stenosis MetaADEDB
Catalepsy MetaADEDB
Cataract MetaADEDB
Cellulitis Gangrenous ADReCS
Cerebral Circulatory Failure MetaADEDB
Cervical Discharge MetaADEDB
Chest Pain ADReCS
Chicken Pox MetaADEDB
Chills ADReCS
Choking Sensation MetaADEDB
Cholangiolitis MetaADEDB
Cholangitis MetaADEDB
Cholecystitis ADReCS
Cholelithiasis ADReCS
Cholestasis ADReCS
Chromaturia ADReCS
Chronic Kidney Disease MetaADEDB
Cirrhosis MetaADEDB
Clostridial Infection MetaADEDB
Clotting MetaADEDB
Colitis ADReCS
Colon Spastic MetaADEDB
Colonic Neoplasms MetaADEDB
Colorectal Neoplasms MetaADEDB
Colour Blindness Acquired MetaADEDB
Coma ADReCS
Confusional State ADReCS
Conjunctivitis ADReCS
Connective Tissue Disorder SIDER
Constipated MetaADEDB
Constipation ADReCS
Convulsion ADReCS
Corneal Ulcer MetaADEDB
Coronary Artery Bypass MetaADEDB
Cramp Muscle SIDER
Crystal Urine ADReCS
Crystalluria ADReCS
Deafness ADReCS
Decreased Appetite ADReCS
Decreased Libido MetaADEDB
Deep Vein Thromboses MetaADEDB
Deglutition Disorder MetaADEDB
Dehydration MetaADEDB
Delirium MetaADEDB
Demyelinating Diseases MetaADEDB
Dental Abscess MetaADEDB
Dental Alveolar Anomaly MetaADEDB
Dental Pain MetaADEDB
Dental Prosthesis Placement MetaADEDB
Depressed Level Of Consciousness ADReCS
Depression ADReCS
Dermatitis ADReCS
Dermatitis Exfoliative ADReCS
Device Related Infection MetaADEDB
Diabetes MetaADEDB
Diabetes Mellitus Inadequate Control MetaADEDB
Diabetes Mellitus Non-Insulin-Dependent MetaADEDB
Diabetic Acidosis MetaADEDB
Diabetic Gastroparesis MetaADEDB
Diabetic Neuropathies MetaADEDB
Diabetic Retinopathy MetaADEDB
Diarrhea MetaADEDB
Diarrhoea ADReCS
Difficulty In Walking MetaADEDB
Discomfort ADReCS
Disease Of Liver MetaADEDB
Disorder Renal MetaADEDB
Disseminated Intravascular Coagulation ADReCS
Disseminated Lupus Erythematosus MetaADEDB
Dizziness ADReCS
Dizziness Exertional MetaADEDB
Dressler Syndrome MetaADEDB
Drug Dose Omission MetaADEDB
Drug Hypersensitivity MetaADEDB
Drug Rash With Eosinophilia And Systemic Symptoms ADReCS
Drug Tolerance MetaADEDB
Drug Withdrawal Headache MetaADEDB
Drug-Induced Liver Injury MetaADEDB
Dry Eye MetaADEDB
Duodenal Ulcer MetaADEDB
Dysgeusia ADReCS
Dyspepsia ADReCS
Dyspnea MetaADEDB
Dyspnoea ADReCS
Dysthymic Disorder MetaADEDB
Dysuria ADReCS
Eating Disorder MetaADEDB
Ecchymosis ADReCS
Edema Extremities MetaADEDB
Effusion ADReCS
Ejection Fraction Decreased MetaADEDB
Electromechanical Dissociation MetaADEDB
Embolism Pulmonary MetaADEDB
Emotional Distress MetaADEDB
Emphysema MetaADEDB
Endocarditis MetaADEDB
Endometriosis MetaADEDB
Eosinophilia ADReCS
Epistaxis ADReCS
Eruption MetaADEDB
Erythema ADReCS
Erythema Multiforme ADReCS
Esophageal Neoplasms MetaADEDB
Essential Hypertension MetaADEDB
Exanthema MetaADEDB
Excess Potassium MetaADEDB
Excessive Sleepiness MetaADEDB
Exophthalmos MetaADEDB
Extremity Pain MetaADEDB
Face Injury MetaADEDB
Faecaloma MetaADEDB
Faeces Pale MetaADEDB
Fasciculation MetaADEDB
Fasciitis ADReCS
Fat Tissue Increased MetaADEDB
Fatigue ADReCS
Fatty Liver MetaADEDB
Fear Of Eating MetaADEDB
Feeling Abnormal ADReCS
Fever MetaADEDB
Fib MetaADEDB
Fibroids MetaADEDB
Fibromatosis Abdominal MetaADEDB
Fibromatosis Aggressive MetaADEDB
Flatulence ADReCS
Flushing ADReCS
Fungal Disease MetaADEDB
Gall Bladder MetaADEDB
Gallbladder Operation MetaADEDB
Gamma-Glutamyltransferase Increased MetaADEDB
Gastric Disorder ADReCS
Gastric Mucosal Lesion MetaADEDB
Gastric Ulcer MetaADEDB
Gastritis ADReCS
Gastroenteritis ADReCS
Gastroesophageal Reflux MetaADEDB
Gastrointestinal Bleed MetaADEDB
Gastrointestinal Cramps ADReCS
Gastrointestinal Haemorrhage ADReCS
Gastrointestinal Pain ADReCS
Gastrointestinal Perforation ADReCS
Glomerular Filtration Rate Decreased MetaADEDB
Glossitis ADReCS
Glucose Urine MetaADEDB
Granuloma MetaADEDB
Gynaecomastia ADReCS
Haematuria ADReCS
Haemobilia MetaADEDB
Haemodialysis MetaADEDB
Haemoglobin ADReCS
Haemolytic Anaemia ADReCS
Haemorrhage ADReCS
Haemosiderosis MetaADEDB
Hallucinations MetaADEDB
Headache ADReCS
Hearing Impaired ADReCS
Hearing Loss MetaADEDB
Heart Attack MetaADEDB
Heart Rate Increased MetaADEDB
Helicobacter Pylori Identification Test Positive MetaADEDB
Hepatic Congestion MetaADEDB
Hepatic Failure ADReCS
Hepatic Function Abnormal ADReCS
Hepatitis ADReCS
Hepatitis Acute MetaADEDB
Hepatitis B Positive MetaADEDB
Hepatomegaly MetaADEDB
Hernia Hiatal MetaADEDB
Herpes Virus Infection MetaADEDB
Herpes Zoster MetaADEDB
High Density Lipoprotein Decreased MetaADEDB
High Risk Pregnancy MetaADEDB
Homicidal Ideation MetaADEDB
Hostility MetaADEDB
Hot Flash MetaADEDB
Hydronephrosis MetaADEDB
Hyperglycaemia ADReCS
Hyperhidrosis ADReCS
Hyperkalaemia ADReCS
Hyperkalemia MetaADEDB
Hyperkeratosis MetaADEDB
Hypersensitive Syndrome SIDER
Hypersensitivity ADReCS
Hypertension ADReCS
Hypertensive Heart Disease MetaADEDB
Hypoacusis ADReCS
Hypoaesthesia MetaADEDB
Hypokalaemia MetaADEDB
Hypomagnesaemia MetaADEDB
Hypotension ADReCS
Hypotension Orthostatic MetaADEDB
Hypothermia MetaADEDB
Ild MetaADEDB
Ileal Ulcer MetaADEDB
Ill-Defined Disorder ADReCS
Immobile MetaADEDB
Implantable Defibrillator Insertion MetaADEDB
Infection ADReCS
Infection Upper Respiratory MetaADEDB
Infection Urinary Tract MetaADEDB
Inflammation MetaADEDB
Injection Site Urticaria MetaADEDB
Insomnia ADReCS
Intervertebral Disc Disorder MetaADEDB
Intestinal Neoplasms MetaADEDB
Intestinal Polyps MetaADEDB
Intestinal Stenosis ADReCS
Iron Deficiency Anaemia MetaADEDB
Ischias MetaADEDB
Itch MetaADEDB
Jaundice ADReCS
Jaundice Obstructive MetaADEDB
Jaw Operation MetaADEDB
Joint Sprain MetaADEDB
Kaposi Varicelliform Eruption MetaADEDB
Kidney Failure Chronic MetaADEDB
Kidney Papillary Necrosis MetaADEDB
Klebsiella Infection MetaADEDB
Lactose Intolerance MetaADEDB
Large Intestinal Ulcer MetaADEDB
Large Intestine Perforation MetaADEDB
Left Ventricular Dysfunction MetaADEDB
Leukocytoclastic Vasculitis ADReCS
Leukocytosis ADReCS
Leukopenia ADReCS
Leukopenia Neonatal MetaADEDB
Ligament Rupture MetaADEDB
Ligament Sprain MetaADEDB
Listeria Sepsis MetaADEDB
Liver Abscess MetaADEDB
Liver Cirrhosis Biliary MetaADEDB
Liver Diseases MetaADEDB
Localised Infection MetaADEDB
Loose Tooth MetaADEDB
Loss Of Consciousness ADReCS
Lower Gastrointestinal Haemorrhage MetaADEDB
Lung Fibrosis MetaADEDB
Lung Infection MetaADEDB
Lung Neoplasms MetaADEDB
Lupus Erythematosus SIDER
Lyell MetaADEDB
Lymphadenectomy MetaADEDB
Lymphadenitis ADReCS
Major Depression MetaADEDB
Malaise ADReCS
Malaria MetaADEDB
Marfan Syndrome MetaADEDB
Mastectomy MetaADEDB
Mean Cell Haemoglobin MetaADEDB
Mean Cell Volume Increased MetaADEDB
Melanoma MetaADEDB
Memory Disorders MetaADEDB
Meningism MetaADEDB
Meningitis ADReCS
Meningitis Aseptic ADReCS
Mental Impairment MetaADEDB
Metabolic Acidosis MetaADEDB
Metabolic Disorder ADReCS
Metastases To Central Nervous System MetaADEDB
Metastases To Lung MetaADEDB
Mixed Connective Tissue Disease ADReCS
Mononeuritis MetaADEDB
Mouth Ulcer MetaADEDB
Mucosal Inflammation ADReCS
Mucous Membrane Disorder ADReCS
Muscle Cramp MetaADEDB
Muscle Spasms ADReCS
Muscle Weakness MetaADEDB
Muscular Diseases MetaADEDB
Muscular Weakness ADReCS
Musculoskeletal Chest Pain MetaADEDB
Musculoskeletal Discomfort ADReCS
Musculoskeletal Disorder MetaADEDB
Musculoskeletal Stiffness MetaADEDB
Myalgia ADReCS
Mycobacterium Tuberculosis Infection MetaADEDB
Myopia MetaADEDB
Nail Tinea MetaADEDB
Nasal Sinus Congestion MetaADEDB
Nausea ADReCS
Necrolysis Epidermal SIDER
Necrotising Fasciitis ADReCS
Neoplasms Experimental MetaADEDB
Nephritic Syndrome ADReCS
Nephritis ADReCS
Nephritis Interstitial SIDER
Nephrocalcinosis MetaADEDB
Nephrolithiasis ADReCS
Nephrotic Syndrome ADReCS
Nervous Tension MetaADEDB
Nervousness ADReCS
Neumonia MetaADEDB
Neuritis ADReCS
Neurodegenerative Diseases MetaADEDB
Neuropathy Peripheral ADReCS
Neurotoxicity ADReCS
Neutropenia ADReCS
Non-Small Cell Lung Cancer MetaADEDB
Normochromic Normocytic Anaemia MetaADEDB
Oedema ADReCS
Oestrogen Receptor Assay Positive MetaADEDB
Osteoarthritis MetaADEDB
Osteomyelitis MetaADEDB
Osteosclerosis MetaADEDB
Pain ADReCS
Palpitation MetaADEDB
Palpitations ADReCS
Pancreatic Neoplasms MetaADEDB
Pancreatic Pseudocyst MetaADEDB
Pancreatitis ADReCS
Pancytopenia ADReCS
Paraesthesia ADReCS
Paresthesia MetaADEDB
Patellofemoral Pain Syndrome MetaADEDB
Peptic Ulcer ADReCS
Peripheral Nervous System Diseases MetaADEDB
Peritonitis MetaADEDB
Photophobia MetaADEDB
Photosensitivity SIDER
Photosensitivity Reaction ADReCS
Pleural Disorder ADReCS
Pleural Effusion ADReCS
Pneumocystis Jiroveci Pneumonia MetaADEDB
Pneumonia ADReCS
Pollakiuria MetaADEDB
Post Herpetic Neuralgia MetaADEDB
Post Nasal Drip MetaADEDB
Postmenopausal Bleeding MetaADEDB
Precancerous Conditions MetaADEDB
Precancerous Skin Lesion MetaADEDB
Presbyopia MetaADEDB
Procedural Pain MetaADEDB
Prostate Examination Abnormal MetaADEDB
Prostatitis MetaADEDB
Prostatomegaly MetaADEDB
Protein Total Decreased MetaADEDB
Protein Urine Present ADReCS
Proteinuria ADReCS
Prothrombin Level Increased ADReCS
Prothrombin Time Prolonged ADReCS
Pruritus ADReCS
Pseudomonal Bacteraemia MetaADEDB
Psoriasis MetaADEDB
Psychoses Substance-Induced MetaADEDB
Psychotic Disorder ADReCS
Pulmonary Arrest MetaADEDB
Pupil Fixed MetaADEDB
Purpura ADReCS
Purulent Discharge MetaADEDB
Pyrexia ADReCS
Radiotherapy MetaADEDB
Rash ADReCS
Red Cell Distribution Width Increased MetaADEDB
Renal Atrophy MetaADEDB
Renal Disorder ADReCS
Renal Failure ADReCS
Renal Impairment ADReCS
Renal Insufficiency MetaADEDB
Respiratory Disorder MetaADEDB
Retinal Disorder ADReCS
Rheumatic Diseases MetaADEDB
Rhinitis MetaADEDB
Rib Fracture MetaADEDB
Right Atrial Dilatation MetaADEDB
Seizures MetaADEDB
Self-Injurious Ideation MetaADEDB
Sensory Loss MetaADEDB
Sequestrectomy MetaADEDB
Shock ADReCS
Shock Haemorrhagic MetaADEDB
Sinus Headache MetaADEDB
Skin Disorder ADReCS
Sleep Apnea MetaADEDB
Sleep Disorder MetaADEDB
Sleep Walking MetaADEDB
Somnolence ADReCS
Stent Placement MetaADEDB
Stevens-Johnson Syndrome ADReCS
Stitch Abscess MetaADEDB
Stomatitis ADReCS
Stress MetaADEDB
Stupor ADReCS
Subarachnoid Haemorrhage MetaADEDB
Sudden Death ADReCS
Supraventricular Tachycardia MetaADEDB
Sweating Increased SIDER
Syncope ADReCS
Systemic Lupus Erythematosus ADReCS
Tachycardia ADReCS
Tachycardia Ventricular MetaADEDB
Tardive Dyskinesia MetaADEDB
Taste Bitter ADReCS
Tenderness ADReCS
Tendinitis MetaADEDB
Tenosynovitis MetaADEDB
Tension ADReCS
Thrombocytopenia ADReCS
Tinea Pedis MetaADEDB
Tinnitus ADReCS
Tobacco User MetaADEDB
Tooth Fracture MetaADEDB
Toxic Encephalopathy MetaADEDB
Toxic Epidermal Necrolysis ADReCS
Toxic Skin Eruption MetaADEDB
Treatment Noncompliance MetaADEDB
Troponin Increased MetaADEDB
Tuberculosis Of Genitourinary System MetaADEDB
Tubulointerstitial Nephritis ADReCS
Ulcer ADReCS
Upper Gastrointestinal Bleeding MetaADEDB
Urinary Tract Infection Bacterial MetaADEDB
Urine Colour Abnormal ADReCS
Urine Output ADReCS
Urticaria ADReCS
Uterine Enlargement MetaADEDB
Uterine Neoplasms MetaADEDB
Vaginal Haemorrhage ADReCS
Vascular Purpura ADReCS
Vasculitis ADReCS
Vertigo ADReCS
Vision Blurred ADReCS
Vision Disorders MetaADEDB
Visual Disturbance ADReCS
Visual Impairment ADReCS
Vomiting ADReCS
Vulvovaginal Mycotic Infection MetaADEDB
Weakness SIDER
Weight Gain MetaADEDB
Wound MetaADEDB
Wound Complication MetaADEDB

InAADR: Drug-Protein-ADRs database