| Drug Name: | Sulfasalazine (599-79-1) |
|---|---|
| PubChem ID: | 5384001 |
| SMILES: | C1=CC=NC(=C1)NS(=O)(=O)C2=CC=C(C=C2)NN=C3C=CC(=O)C(=C3)C(=O)O |
| InchiKey: | OQANPHBRHBJGNZ-UHFFFAOYSA-N |
| Therapeutic Category: | Analgesics, Anti-Infective Agents, Anti-Inflammatory Agents, Antirheumatic Agents, Gastrointestinal Agents, Peripheral Nervous System Agents, Sensory System Agents |
| Molecular Weight (dalton) | : | 398.4 |
| LogP | : | 1.8002 |
| Ring Count | : | 2 |
| Hydrogen Bond Acceptor Count | : | 7 |
| Hydrogen Bond Donor Count | : | 3 |
| Total Polar Surface Area | : | 137.82 |
This panel provides information on interacting drugs and their ADRs along with references
| Interacting drug | Toxicity | Interaction Type | Mechanism | Reference |
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This panel provides drug-protein interaction and their ADRs along with references
| Toxicity | Interacting Protein | Mechanism | Reference |
|---|---|---|---|
| Leucopenia | Cytochrome P450 1A2 (P05177) | In patients with Crohn#s disease receiving azathioprine or 6-mercaptopurine@ coadministration of mesalamine@ sulphasalazine@ and possibly balsalazide results in an increase in whole blood 6-thioguanine nucleotide concentrations and a high frequency of leucopenia [ ADR Type 4 ] | Lowry PW, Franklin CL, Weaver AL, Szumlanski CL, Mays DC, Loftus EV, Tremaine WJ, Lipsky JJ, Weinshilboum RM, Sandborn WJ Leucopenia resulting from a drug interaction between azathioprine or 6-mercaptopurine and mesalamine, sulphasalazine, or balsalazide |
| Vasculitis | Myeloperoxidase precursor (P05164) | Perinuclear antineutrophil cytoplasmic antibodies with specificity for myeloperoxidase were found critically increased just before the occurrence of vasculitis. [ ADR Type 3 ] | Sulfasalazine induced lupus in rheumatoid arthritis |
This panel provides drug-food interactions and their ADRs along with references
| Food | Toxicity | Reference |
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This panel provides information on metabolites and their ADRs along with references
| Metabolite | Toxicity | Place of Metabolism | Mechanism | Reference |
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This panel provides information on drug category