InAADR

Drug Information

Drug Name: Sitagliptin (486460-32-6)
PubChem ID: 4369359
SMILES: C1CN2C(=NN=C2C(F)(F)F)CN1C(=O)C[C@@H](CC3=CC(=C(C=C3F)F)F)N
InchiKey: MFFMDFFZMYYVKS-SECBINFHSA-N
Therapeutic Category: Dipeptidyl-Peptidase IV Inhibitors, Enzyme Inhibitors, Hormones, Hypoglycemic Agents, Incretins, Protease Inhibitors

Computed Drug Properties

Molecular Weight (dalton): 407.318
LogP: 2.0165
Ring Count: 2
Hydrogen Bond Acceptor Count: 5
Hydrogen Bond Donor Count: 1
Total Polar Surface Area: 77.04

This panel provides information on interacting drugs and their ADRs along with references

Interacting drug Toxicity Interaction Type Mechanism Reference

This panel provides drug-protein interaction and their ADRs along with references

Toxicity Interacting Protein Mechanism Reference

This panel provides drug-food interactions and their ADRs along with references

Food Toxicity Reference

This panel provides information on metabolites and their ADRs along with references

Metabolite Toxicity Place of Metabolism Mechanism Reference

This panel provides information on drug category

Toxicity Source
Abdominal Discomfort ADReCS
Abdominal Pain ADReCS
Abdominal Pain ADReCS
Abnormal Lfts MetaADEDB
Abscess Limb MetaADEDB
Aching Muscles MetaADEDB
Acute Abdomen MetaADEDB
Acute Interstitial Pneumonitis MetaADEDB
Acute Leukaemia MetaADEDB
Acute Myeloblastic Leukemia MetaADEDB
Acute Pancreatitis MetaADEDB
Adrenal Suppression MetaADEDB
Adverse Event MetaADEDB
Adverse Reaction MetaADEDB
Adynamic Ileus MetaADEDB
Ageusia MetaADEDB
Agoraphobia MetaADEDB
Allergic Alveolitis MetaADEDB
Allergic Dermatitis MetaADEDB
Allergic Vasculitis MetaADEDB
Alopecia MetaADEDB
Amentia MetaADEDB
Anal Fistula MetaADEDB
Anaphylactic Reaction ADReCS
Anaphylactic Shock ADReCS
Androgen Deficiency MetaADEDB
Anemia Aplastic MetaADEDB
Angiitis MetaADEDB
Angina Pectoris SIDER
Angioedema ADReCS
Angiopathy ADReCS
Anhedonia MetaADEDB
Anorectal Disorder MetaADEDB
Anuria MetaADEDB
Anxiety ADReCS
Aortic Aneurysm SIDER
Aortic Dissection SIDER
Aphonia MetaADEDB
Appendicitis MetaADEDB
Appendix Disorder MetaADEDB
Appetite Disorder MetaADEDB
Application Site Dermatitis MetaADEDB
Aptyalism MetaADEDB
Arthralgia ADReCS
Aseptic Meningitis MetaADEDB
Asthenia ADReCS
Asthenospermia MetaADEDB
Atrial Septal Defect MetaADEDB
Autoimmune Hepatitis MetaADEDB
Autonomic Instability MetaADEDB
Azoospermia MetaADEDB
Back Pain ADReCS
Bacterial Vaginitis MetaADEDB
Balanitis MetaADEDB
Biliary Dilatation MetaADEDB
Blastomycosis MetaADEDB
Bleb MetaADEDB
Blood 25-Hydroxycholecalciferol Decreased MetaADEDB
Blood Amylase Increased MetaADEDB
Blood Creatine Decreased MetaADEDB
Blood Creatine Increased MetaADEDB
Blood Creatinine Decreased MetaADEDB
Blood Creatinine Increased MetaADEDB
Blood Elastase Increased MetaADEDB
Blood Glucose Abnormal MetaADEDB
Blood Glucose Decreased ADReCS
Blood Glucose Increased ADReCS
Blood Homocysteine MetaADEDB
Blood Urea MetaADEDB
Blurred Vision MetaADEDB
Bone Operation MetaADEDB
Brain Natriuretic Peptide Increased MetaADEDB
Brain Oedema MetaADEDB
Breast Disorder SIDER
Breast Enlargement MetaADEDB
Bronchitis SIDER
Bronchitis ADReCS
Bundle Branch Block ADReCS
Calcium Ionised Increased MetaADEDB
Carbohydrate Antigen 19-9 MetaADEDB
Cardiac Death MetaADEDB
Cardiac Disorder ADReCS
Cardiac Pain SIDER
Cardioactive Drug Level Increased MetaADEDB
Carotid Bruit MetaADEDB
Catheter Site Cellulitis MetaADEDB
Cellulitis ADReCS
Central Nervous System Inflammation MetaADEDB
Central Nervous System Lesion MetaADEDB
Central Venous Catheterisation MetaADEDB
Cerumen Impaction MetaADEDB
Cervicalgia MetaADEDB
Chest Pain ADReCS
Cholecystitis MetaADEDB
Cholecystitis Infective MetaADEDB
Chondritis MetaADEDB
Chronic Active Hepatitis MetaADEDB
Clotting MetaADEDB
Colon Adenoma MetaADEDB
Completed Suicide MetaADEDB
Complex Partial Seizures MetaADEDB
Connective Tissue Disorder SIDER
Constipated MetaADEDB
Constipation ADReCS
Corneal Striae MetaADEDB
Coronary Artery Insufficiency MetaADEDB
Cough ADReCS
Cranial Nerve Infection MetaADEDB
Creatinine Renal Clearance Decreased MetaADEDB
Creatinine Renal Clearance Increased MetaADEDB
Critical Illness Polyneuropathy MetaADEDB
Cutaneous Vasculitis ADReCS
Cyclic Vomiting Syndrome MetaADEDB
Decreased Appetite ADReCS
Decreased Immune Responsiveness MetaADEDB
Decreased Lacrimation MetaADEDB
Deglutition Disorder MetaADEDB
Delusional Disorder Persecutory Type MetaADEDB
Dependence On Respirator MetaADEDB
Dermatitides MetaADEDB
Dermatitis ADReCS
Dermatitis Bullous MetaADEDB
Dermatitis Medicamentosa MetaADEDB
Dermatitis Psoriasiform MetaADEDB
Dermographism MetaADEDB
Diabetic Vascular Disorder MetaADEDB
Diarrhea MetaADEDB
Diarrhoea ADReCS
Discomfort ADReCS
Diverticular Perforation MetaADEDB
Dizziness ADReCS
Drowning MetaADEDB
Drug Administration Error MetaADEDB
Drug Ineffective MetaADEDB
Drug Intolerance MetaADEDB
Drug Screen MetaADEDB
Drug Screen Positive MetaADEDB
Drug Withdrawal Headache MetaADEDB
Dry Mouth PROTECT
Dysmenorrhoea ADReCS
Dyspepsia ADReCS
Dysphonia MetaADEDB
Ear Ache MetaADEDB
Ear Discomfort MetaADEDB
Economic Problem MetaADEDB
Eczema ADReCS
Ejaculation Failure MetaADEDB
Ejection Fraction Decreased MetaADEDB
Elevated Erythrocyte Sedimentation Rate MetaADEDB
Elevated Mood MetaADEDB
Encephalitis Brain Stem MetaADEDB
Epiglottitis MetaADEDB
Epistaxis MetaADEDB
Erectile Dysfunction ADReCS
Eruption MetaADEDB
Erythema Multiforme MetaADEDB
Erythema Of Eyelid MetaADEDB
Eschar MetaADEDB
Exfoliative Rash MetaADEDB
Eye Disorder SIDER
Eye Infection MetaADEDB
Eye Pruritus MetaADEDB
Eye Rolling MetaADEDB
Eye Swelling MetaADEDB
Face Oedema ADReCS
Fat Intolerance MetaADEDB
Fatigue ADReCS
Feeling Abnormal ADReCS
Feeling Of Body Temperature Change MetaADEDB
Flashing Lights MetaADEDB
Flatulence ADReCS
Foetal Growth Retardation MetaADEDB
Foetal Hypokinesia MetaADEDB
Food Allergy MetaADEDB
Formication MetaADEDB
Gammopathy MetaADEDB
Gastric Ulcer ADReCS
Gastric Ulcer Perforated MetaADEDB
Gastritis ADReCS
Gastroenteritis ADReCS
Gastrointestinal Anastomotic Leak MetaADEDB
Gastrointestinal Disorder SIDER
Gastrointestinal Motility Disorder MetaADEDB
Gastrointestinal Oedema MetaADEDB
Gastrointestinal Pain ADReCS
Gastrooesophageal Reflux Disease ADReCS
Genital Rash MetaADEDB
Gingival Erosion MetaADEDB
Glomerular Filtration Rate Decreased MetaADEDB
Glomerular Filtration Rate Increased MetaADEDB
Glomerulosclerosis MetaADEDB
Glucose Decreased SIDER
Glucose Increased SIDER
Glycosylated Haemoglobin MetaADEDB
Glycosylated Haemoglobin Increased MetaADEDB
Granulocyte Count Increased MetaADEDB
Granulomatous Liver Disease MetaADEDB
Head Titubation MetaADEDB
Headache ADReCS
Helicobacter Gastritis ADReCS
Hemicephalalgia MetaADEDB
Hepatic Cancer Metastatic MetaADEDB
Hepatic Enzyme MetaADEDB
Hepatic Enzyme Increased ADReCS
Hepatic Mass MetaADEDB
Hepatic Steatosis ADReCS
Hepatitis MetaADEDB
Hepatobiliary Disease SIDER
Herpes Nos SIDER
Herpes Virus Infection ADReCS
Herpes Zoster ADReCS
Histoplasmosis MetaADEDB
Histoplasmosis Disseminated MetaADEDB
Homicidal Ideation MetaADEDB
Hydroureter MetaADEDB
Hyperglycaemia ADReCS
Hypersensitivity ADReCS
Hypertension ADReCS
Hypoaesthesia ADReCS
Hypoglycaemia ADReCS
Hypotension ADReCS
Idiopathic Thrombocytopenic Purpura MetaADEDB
Idiopathic Urticaria MetaADEDB
Ild MetaADEDB
Ill-Defined Disorder ADReCS
Impaired Driving Ability MetaADEDB
Impaired Gastric Emptying MetaADEDB
Implant Site Erythema MetaADEDB
Inability To Crawl MetaADEDB
Inappropriate Schedule Of Drug Administration MetaADEDB
Increased Upper Airway Secretion MetaADEDB
Infection ADReCS
Infection Upper Respiratory MetaADEDB
Infestation SIDER
Infestation Nos SIDER
Influenza ADReCS
Influenza Like Illness MetaADEDB
Inhalation Therapy MetaADEDB
Insomnia ADReCS
International Normalised Ratio MetaADEDB
International Normalised Ratio Decreased MetaADEDB
International Normalised Ratio Fluctuation MetaADEDB
International Normalised Ratio Increased MetaADEDB
Interstitial Lung Disease PROTECT
Intestinal Infarction MetaADEDB
Intra-abdominal haematoma MetaADEDB
Intraocular Pressure Decreased MetaADEDB
Iritis MetaADEDB
Irregular Menstrual Cycle MetaADEDB
Itch MetaADEDB
Kidney Malformation MetaADEDB
Kidney Pain MetaADEDB
Labour Complication MetaADEDB
Large Intestinal Haemorrhage MetaADEDB
Laryngeal Inflammation MetaADEDB
Learning Disorder MetaADEDB
Left Ventricular Hypertrophy MetaADEDB
Limb Discomfort MetaADEDB
Lip Blister MetaADEDB
Lip Dry MetaADEDB
Lip Exfoliation MetaADEDB
Lip Ulceration MetaADEDB
Lipase MetaADEDB
Lipids Increased MetaADEDB
Local Swelling MetaADEDB
Loss Of Proprioception MetaADEDB
Lower Respiratory Tract Infection Fungal MetaADEDB
Ludwig Angina MetaADEDB
Lung Transplant MetaADEDB
Malaise ADReCS
Malignant Hypertension MetaADEDB
Mastoiditis MetaADEDB
Mean Platelet Volume MetaADEDB
Meconium Stain MetaADEDB
Mediastinal Disorder SIDER
Mediastinitis MetaADEDB
Medication Residue MetaADEDB
Meibomianitis MetaADEDB
Meningioma MetaADEDB
Meningitis Viral MetaADEDB
Mental Disability MetaADEDB
Mental Disorder SIDER
Metabolic Function Test MetaADEDB
Migraine ADReCS
Migraine With Aura MetaADEDB
Mixed Connective Tissue Disease MetaADEDB
Mixed Hyperlipidaemia MetaADEDB
Multiple Injuries MetaADEDB
Muscle Spasms ADReCS
Muscle Tightness ADReCS
Musculoskeletal Chest Pain MetaADEDB
Musculoskeletal Discomfort ADReCS
Musculoskeletal Pain ADReCS
Myalgia ADReCS
Myoclonic Epilepsy MetaADEDB
Myopia MetaADEDB
Nasal Congestion MetaADEDB
Nasal Discomfort MetaADEDB
Nasal Dryness MetaADEDB
Nasal Ulcer MetaADEDB
Nasopharyngitis ADReCS
Nausea ADReCS
Neck Pain ADReCS
Necrotising Colitis MetaADEDB
Nephrolithiasis ADReCS
Nervous System Disorder SIDER
Neural Tube Defect MetaADEDB
Neuropathy ADReCS
Neuropathy Peripheral ADReCS
Nocturia MetaADEDB
Normochromic Normocytic Anaemia MetaADEDB
Obstructive Uropathy MetaADEDB
Oedema ADReCS
Oedema Mouth MetaADEDB
Oedema Peripheral ADReCS
Oesophageal Discomfort MetaADEDB
Oesophageal Oedema MetaADEDB
Oesophagitis ADReCS
Oestrogen Receptor Assay Positive MetaADEDB
Off Label Use MetaADEDB
Oral Mucosal Blistering MetaADEDB
Oropharyngeal Blistering MetaADEDB
Oropharyngeal Pain ADReCS
Orthopnea MetaADEDB
Orthostatic Hypotension ADReCS
Osteoarthritis ADReCS
Ototoxicity MetaADEDB
Ovarian Adenoma MetaADEDB
Overdose MetaADEDB
Pain ADReCS
Pain In Extremity ADReCS
Pain In Throat MetaADEDB
Pain Pelvic MetaADEDB
Palatal Oedema MetaADEDB
Palpable Purpura MetaADEDB
Palpitation MetaADEDB
Pancreatic Cancer MetaADEDB
Pancreatic Carcinoma Stage Iv MetaADEDB
Pancreatic Cyst MetaADEDB
Pancreatic Enzymes Increased MetaADEDB
Pancreatic Islets Hyperplasia MetaADEDB
Pancreatitis ADReCS
Pancreatitis Acute ADReCS
Pancreatitis Chronic MetaADEDB
Pancreatitis Necrotising PROTECT
Paraesthesia Oral MetaADEDB
Parosmia ADReCS
Parotid Gland Enlargement MetaADEDB
Penile Abscess MetaADEDB
Penile Infection MetaADEDB
Penile Necrosis MetaADEDB
Performance Status Decreased MetaADEDB
Perianal Abscess MetaADEDB
Perineal Abscess MetaADEDB
Peritoneal Effusion MetaADEDB
Petechia MetaADEDB
Pharyngeal Inflammation MetaADEDB
Pharyngitis ADReCS
Pharyngolaryngeal Pain SIDER
Physical Assault MetaADEDB
Physical Testicle Examination Abnormal MetaADEDB
Pickwickian Syndrome MetaADEDB
Pleural Fibrosis MetaADEDB
Pneumonia ADReCS
Pneumonia Fungal MetaADEDB
Pneumonia Haemophilus MetaADEDB
Pneumoperitoneum MetaADEDB
Pollakiuria MetaADEDB
Poor Quality Sleep MetaADEDB
Post Inflammatory Pigmentation Change MetaADEDB
Post Nasal Drip MetaADEDB
Presbyopia MetaADEDB
Productive Cough MetaADEDB
Progressive Supranuclear Palsy MetaADEDB
Prostatic Haemorrhage MetaADEDB
Prostatomegaly MetaADEDB
Prothrombin Time Prolonged MetaADEDB
Pruritus Generalised MetaADEDB
Pseudocyst MetaADEDB
Psoriasis MetaADEDB
Pulmonary Hilum Mass MetaADEDB
Pyelonephritis MetaADEDB
Rash ADReCS
Rash Generalised MetaADEDB
Reflux Oesophagitis ADReCS
Renal Embolism MetaADEDB
Renal Failure Acute ADReCS
Renal Impairment ADReCS
Renal Infarct MetaADEDB
Renal Mass MetaADEDB
Respiratory Disorder MetaADEDB
Respiratory Tract Congestion MetaADEDB
Respiratory Tract Infection ADReCS
Respiratory Tract Infection Bacterial MetaADEDB
Retching ADReCS
Retinal Vascular Thrombosis MetaADEDB
Rhinitis MetaADEDB
Rhinorrhea MetaADEDB
Risus Sardonicus MetaADEDB
Saliva Altered MetaADEDB
Sciatica ADReCS
Scleral Haemorrhage MetaADEDB
Scrotal Swelling MetaADEDB
Semen Volume Decreased MetaADEDB
Seroma MetaADEDB
Shoulder Pain ADReCS
Sinus Congestion ADReCS
Sinus Headache ADReCS
Sinusitis ADReCS
Skin Discolouration MetaADEDB
Skin Disorder ADReCS
Skin Exfoliation ADReCS
Small For Dates Baby MetaADEDB
Snoring MetaADEDB
Social Problem MetaADEDB
Somatisation Disorder MetaADEDB
Somnolence ADReCS
Spinning Sensation MetaADEDB
Stevens-Johnson Syndrome PROTECT
Swollen Tongue MetaADEDB
Syncope Vasovagal MetaADEDB
Tachycardia Foetal MetaADEDB
Testicular Atrophy MetaADEDB
Testicular Mass MetaADEDB
Thalamic Infarction MetaADEDB
Therapeutic Response Decreased MetaADEDB
Therapeutic Response Unexpected MetaADEDB
Throat Tightness MetaADEDB
Tinea Cruris MetaADEDB
Tooth Infection ADReCS
Toothache ADReCS
Total Lung Capacity Decreased MetaADEDB
Tracheal Disorder MetaADEDB
Tracheal Fistula MetaADEDB
Tracheobronchitis ADReCS
Transfusion MetaADEDB
Tubulointerstitial Nephritis MetaADEDB
Tumour Lysis Syndrome MetaADEDB
Tympanic Membrane Disorder MetaADEDB
Tympanic Membrane Perforation MetaADEDB
Ulcer ADReCS
Upper Respiratory Tract Infection ADReCS
Urethral Disorder SIDER
Urethral Haemorrhage MetaADEDB
Urinary Tract Disorder SIDER
Urinary Tract Infection ADReCS
Urine Odour Abnormal MetaADEDB
Urticaria ADReCS
Uterine Cancer MetaADEDB
Uterine Spasm MetaADEDB
Velopharyngeal Incompetence MetaADEDB
Venoocclusive Disease MetaADEDB
Vertigo ADReCS
Viral Diarrhoea ADReCS
Vision Blurred ADReCS
Vitrectomy MetaADEDB
Vomiting ADReCS
Vulvovaginal Pain MetaADEDB
Weight Abnormal MetaADEDB
Weight Bearing Difficulty MetaADEDB
Weight Increased ADReCS
White Blood Cell Count Abnormal MetaADEDB
White Blood Cell Count Increased ADReCS
Wound Evisceration MetaADEDB
Wrong Technique In Drug Usage Process MetaADEDB

InAADR: Drug-Protein-ADRs database