InAADR

Drug Information

Drug Name: Procainamide (51-06-9)
PubChem ID: 4913
SMILES: CCN(CC)CCNC(=O)C1=CC=C(C=C1)N
InchiKey: REQCZEXYDRLIBE-UHFFFAOYSA-N
Therapeutic Category: Anti-Arrhythmia Agents, Cardiovascular Agents, Membrane Transport Modulators, Sodium Channel Blockers, Voltage-Gated Sodium Channel Blockers

Computed Drug Properties

Molecular Weight (dalton): 235.331
LogP: 1.3404
Ring Count: 1
Hydrogen Bond Acceptor Count: 3
Hydrogen Bond Donor Count: 2
Total Polar Surface Area: 58.36

This panel provides information on interacting drugs and their ADRs along with references

Interacting drug Toxicity Interaction Type Mechanism Reference
Lidocaine (137-58-6) Delirious Additive Uncertain Plasma levels of lidocaine during combined treatment with phenytoin and procainamide
Lidocaine (137-58-6) Restless Additive Uncertain Plasma levels of lidocaine during combined treatment with phenytoin and procainamide
Amiodarone (1951-25-3) Prolongs The Qt Interval Additive The mechanism behind the pharmacokinetic interaction is not understood. The QT prolonging effects of the two drugs would be expected to be additive. Effect of amiodarone on serum quinidine and procainamide levels
Gatifloxacin (112811-59-3) Torsade De Pointes Antagonistic The probable reason for the interaction is that gatifloxacininhibit the secretion of unchanged procainamide by the kidney tubules via renal drug transporters. It also appears to inhibit the secretion of N-acetylprocainamide Rates of torsades de pointes associated with ciprofloxacin, ofloxacin, levofloxacin, gatifloxacin, and moxifloxacin
Quinidine (56-54-2) Prolongs The Qt Interval Additive It has been suggested that the quinidine interferes with one or more of the renal pathways by which procainamide is cleared from the body Increased procainamide plasma concentrations caused by quinidine: a new drug interaction
Sotalol (3930-20-9) Prolongs The Qt Interval Additive Uncertain Sotalol and type IA drugs in combination prevent recurrence of sustained ventricular tachycardia
Captopril (62571-86-2) Leucopenia Antagonistic Uncertain Effect of Multiple Dose Omeprazole on the Pharmacokinetics of Carbamazepine

This panel provides drug-protein interaction and their ADRs along with references

Toxicity Interacting Protein Mechanism Reference
Hepatotoxicity CYP2D6 (P10635) CYP2D6 is the major human cytochrome P450 isozyme involved in the formation of the reactive metabolite of procainamide@ namely N-hydroxyprocainamide Associated with idiosyncratic hepatotoxicity [ ADR Type 2 ] Role of CYP2D6 in the N-hydroxylation of procainamide
Lupus N-acetyltransferase (P61599) Drug-induced lupus [ ADR Type 5 ] Drugs in special patient groups: clinical importance of genomics in drug effects In: Carruthers GS, Hoffmann BB,Melmon KL, Nierenberg DW
Proarrhythmia CYP2D6 (P10635) Proarrhythmic and other toxic effects [ ADR Type 2 ] Drugs in special patient groups: clinical importance of genomics in drug effects In: Carruthers GS, Hoffmann BB,Melmon KL, Nierenberg DW
Sudden Cardiac Death Potassium voltage-gated channel subfamily E member 1 (P15382) Sudden cardiac death due to long-QT syndrome [ ADR Type 2 ] Genetic and molecular basis of cardiac arrhythmias: impact on clinical management parts I and II
Sudden Cardiac Death Potassium voltage-gated channel subfamily H member 2 (Q12809) Sudden cardiac death due to long-QT syndrome [ ADR Type 2 ] Genetic and molecular basis of cardiac arrhythmias: impact on clinical management parts I and II
Sudden Cardiac Death Potassium voltage-gated channel subfamily KQT member 1 (P51787) Sudden cardiac death due to long-QT syndrome [ ADR Type 2 ] Genetic and molecular basis of cardiac arrhythmias: impact on clinical management parts I and II
Sudden Cardiac Death Sodium channel protein type 5 subunit alpha (Q14524) Sudden cardiac death due to long-QT syndrome [ ADR Type 2 ] Genetic and molecular basis of cardiac arrhythmias: impact on clinical management parts I and II

This panel provides drug-food interactions and their ADRs along with references

Food Toxicity Reference

This panel provides information on metabolites and their ADRs along with references

Metabolite Toxicity Place of Metabolism Mechanism Reference

This panel provides information on drug category

Toxicity Source
Abdominal Discomfort ADReCS
Abdominal Pain ADReCS
Abdominal Pain ADReCS
Acidosis Lactic MetaADEDB
Agranulocytosis ADReCS
Anaemia ADReCS
Anemia MetaADEDB
Anemia Hemolytic MetaADEDB
Anemia Hemolytic Autoimmune MetaADEDB
Angioedema ADReCS
Anorexia ADReCS
Antinuclear Antibody Positive SIDER
Arrhythmia Sinus MetaADEDB
Arrhythmias Cardiac MetaADEDB
Arthralgia ADReCS
Arthritis ADReCS
Asthenia ADReCS
Atrial Fibrillation MetaADEDB
Atrial Flutter MetaADEDB
Atrioventricular Block ADReCS
Atrioventricular Block Second Degree ADReCS
Autoimmune Diseases MetaADEDB
Bipolar Disorder MetaADEDB
Block Heart SIDER
Blood Alkaline Phosphatase Increased ADReCS
Blood Bilirubin Increased ADReCS
Blood Coagulation Disorders MetaADEDB
Body Temperature Increased ADReCS
Bradycardia ADReCS
Bundle-Branch Block MetaADEDB
Cardiac Arrest ADReCS
Cardiac Failure ADReCS
Cardiac Fibrillation ADReCS
Cardiac Output Low MetaADEDB
Cerebellar Ataxia MetaADEDB
Chest Pain MetaADEDB
Chills ADReCS
Cholestasis Intrahepatic MetaADEDB
Coronary Artery Disease MetaADEDB
Death ADReCS
Decreased Appetite ADReCS
Deglutition Disorders MetaADEDB
Delirium MetaADEDB
Depression ADReCS
Dermatitis ADReCS
Diarrhea MetaADEDB
Diarrhoea ADReCS
Discomfort ADReCS
Disseminated Intravascular Coagulation MetaADEDB
Dizziness ADReCS
Drug Eruptions MetaADEDB
Drug Fever ADReCS
Drug Hypersensitivity MetaADEDB
Drug Toxicity MetaADEDB
Dysgeusia ADReCS
Dyspnea MetaADEDB
Effusion ADReCS
Emotional Distress ADReCS
Eosinophilia ADReCS
Exanthema MetaADEDB
Fatigue MetaADEDB
Feeling Abnormal ADReCS
Fever MetaADEDB
Flushing ADReCS
Gastrointestinal Pain ADReCS
Gastrointestinal Tract Irritation ADReCS
Giddiness SIDER
Glomerulonephritis MetaADEDB
Haemolytic Anaemia ADReCS
Hallucination ADReCS
Hallucinations MetaADEDB
Headache MetaADEDB
Heart Arrest MetaADEDB
Heart Block MetaADEDB
Heart Failure MetaADEDB
Heart Rate Abnormal ADReCS
Hepatic Enzyme Increased ADReCS
Hepatic Failure ADReCS
Hypergammaglobulinaemia SIDER
Hypertension MetaADEDB
Hypotension ADReCS
Hypotension Orthostatic MetaADEDB
Ill-Defined Disorder ADReCS
Jaundice Obstructive MetaADEDB
Long Qt Syndrome MetaADEDB
Lupus Erythematosus SIDER
Lupus Erythematosus Cutaneous MetaADEDB
Lupus Erythematosus Systemic MetaADEDB
Lupus Nephritis MetaADEDB
Malaise ADReCS
Muscle Weakness MetaADEDB
Muscular Diseases MetaADEDB
Muscular Weakness ADReCS
Musculoskeletal Discomfort ADReCS
Myalgia ADReCS
Myasthenia Gravis MetaADEDB
Myocardial Infarction MetaADEDB
Myocarditis MetaADEDB
Myoclonus MetaADEDB
Myositis MetaADEDB
Nausea ADReCS
Necrosis MetaADEDB
Nephrotic Syndrome MetaADEDB
Neuromuscular Diseases MetaADEDB
Neutropenia ADReCS
Oedema ADReCS
Pain ADReCS
Pericardial Effusion MetaADEDB
Pericarditis ADReCS
Peripheral Nervous System Diseases MetaADEDB
Pleural Disorder ADReCS
Pleural Effusion ADReCS
Pleurisy MetaADEDB
Pleuritic Pain ADReCS
Polyradiculoneuropathy MetaADEDB
Polyradiculoneuropathy Chronic Inflammatory Demyelinating MetaADEDB
Proteinuria MetaADEDB
Pruritus ADReCS
Psychoses Substance-Induced MetaADEDB
Psychotic Disorder ADReCS
Pyrexia ADReCS
Rash ADReCS
Rash Maculo-Papular ADReCS
Red-Cell Aplasia Pure MetaADEDB
Renal Insufficiency MetaADEDB
Respiratory Insufficiency MetaADEDB
Respiratory Paralysis MetaADEDB
Right Upper Quadrant Pain SIDER
Shock ADReCS
Shock Cardiogenic MetaADEDB
Sleep Initiation And Maintenance Disorders MetaADEDB
Systemic Lupus Erythematosus ADReCS
Tachycardia MetaADEDB
Tachycardia Paroxysmal MetaADEDB
Tachycardia Supraventricular MetaADEDB
Tachycardia Ventricular MetaADEDB
Taste Bitter ADReCS
Thrombocytopenia ADReCS
Thrombosis MetaADEDB
Torsades De Pointes MetaADEDB
Transaminases Increased ADReCS
Tremor MetaADEDB
Urticaria ADReCS
Vasculitis MetaADEDB
Vasculitis Leukocytoclastic Cutaneous MetaADEDB
Ventricular Asystole ADReCS
Ventricular Fibrillation MetaADEDB
Ventricular Premature Complexes MetaADEDB
Vomiting ADReCS
Weakness SIDER
Wolff-Parkinson-White Syndrome MetaADEDB

InAADR: Drug-Protein-ADRs database