| Drug Name: | Phenylpropanolamine (14838-15-4) |
|---|---|
| PubChem ID: | 26934 |
| SMILES: | C[C@H]([C@H](C1=CC=CC=C1)O)N |
| InchiKey: | DLNKOYKMWOXYQA-VXNVDRBHSA-N |
| Therapeutic Category: | Adrenergic Agents, Adrenergic Agonists, Adrenergic alpha-Agonists, Anti-Obesity Agents, Appetite Depressants, Autonomic Agents, Cardiovascular Agents, Central Nervous System Agents, Nasal Decongestants, Neurotransmitter Agents, Peripheral Nervous System Agents, Respiratory System Agents, Sympathomimetics, Vasoconstrictor Agents |
| Molecular Weight (dalton) | : | 151.209 |
| LogP | : | 1.0672 |
| Ring Count | : | 1 |
| Hydrogen Bond Acceptor Count | : | 2 |
| Hydrogen Bond Donor Count | : | 2 |
| Total Polar Surface Area | : | 46.25 |
This panel provides information on interacting drugs and their ADRs along with references
| Interacting drug | Toxicity | Interaction Type | Mechanism | Reference |
|---|---|---|---|---|
| Linezolid (165800-03-3) | Hypertension | Additive | Linezolid acts as a weak MAO-inhibitor, which allows the accumulation of some noradrenaline at adrenergic nerve endings associated with arterial blood vessels. Phenylpropanolamine is indirectly- acting sympathomimetic, can release these above-normal amounts of noradrenaline resulting in blood vessel constriction and a rise in blood pressure | Linezolid: pharmacokinetic and pharmacodynamic evaluation of coadministration with pseudoephedrine HCl, phenylpropanolamine HCl, and dextromethorpan HBr |
| Bromocriptine (25614-03-3) | Vasospasm Cerebral | Additive | Not understood | Bromocriptine-associated headache: possible life-threatening sympathomimetic interaction |
This panel provides drug-protein interaction and their ADRs along with references
| Toxicity | Interacting Protein | Mechanism | Reference |
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This panel provides drug-food interactions and their ADRs along with references
| Food | Toxicity | Reference |
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This panel provides information on metabolites and their ADRs along with references
| Metabolite | Toxicity | Place of Metabolism | Mechanism | Reference |
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This panel provides information on drug category