InAADR

Drug Information

Drug Name: Nitisinone (104206-65-7)
PubChem ID: 115355
SMILES: C1CC(=O)C(C(=O)C1)C(=O)C2=C(C=C(C=C2)C(F)(F)F)[N+](=O)[O-]
InchiKey: OUBCNLGXQFSTLU-UHFFFAOYSA-N
Therapeutic Category: Enzyme Inhibitors

Computed Drug Properties

Molecular Weight (dalton): 329.23
LogP: 2.7346
Ring Count: 1
Hydrogen Bond Acceptor Count: 5
Hydrogen Bond Donor Count: 0
Total Polar Surface Area: 94.35

This panel provides information on interacting drugs and their ADRs along with references

Interacting drug Toxicity Interaction Type Mechanism Reference

This panel provides drug-protein interaction and their ADRs along with references

Toxicity Interacting Protein Mechanism Reference

This panel provides drug-food interactions and their ADRs along with references

Food Toxicity Reference

This panel provides information on metabolites and their ADRs along with references

Metabolite Toxicity Place of Metabolism Mechanism Reference

This panel provides information on drug category

Toxicity Source
Abasia MetaADEDB
Abdominal Pain ADReCS
Abnormal Behaviour MetaADEDB
Activated Partial Thromboplastin Time Prolonged MetaADEDB
Acute Polyneuropathy MetaADEDB
Adrenal Neoplasm MetaADEDB
Allergic Dermatitis MetaADEDB
Alopecia ADReCS
Alpha 1 Foetoprotein Increased MetaADEDB
Amenorrhoea ADReCS
Amino Acid Level Increased PROTECT
Amnesia MetaADEDB
Anaemia MetaADEDB
Anaesthesia MetaADEDB
Anger MetaADEDB
Apnea MetaADEDB
Appendicitis MetaADEDB
Ascites MetaADEDB
Bacterial Toxaemia MetaADEDB
Blepharitis ADReCS
Body Temperature Increased MetaADEDB
Brain Neoplasm ADReCS
Bronchitis ADReCS
Bulbar Palsy MetaADEDB
Cardioactive Drug Level MetaADEDB
Cataract ADReCS
Cirrhosis MetaADEDB
Clotting MetaADEDB
Cognitive Disorder MetaADEDB
Complications Of Transplanted Liver MetaADEDB
Condition Aggravated MetaADEDB
Conjunctival Deposit MetaADEDB
Conjunctivitis ADReCS
Convulsion ADReCS
Convulsions Grand Mal MetaADEDB
Corneal Opacity ADReCS
Cyanosis ADReCS
Cytolytic Hepatitis MetaADEDB
Death ADReCS
Dehydration ADReCS
Dermatitis Exfoliative ADReCS
Developmental Delay MetaADEDB
Diarrhea MetaADEDB
Diarrhoea ADReCS
Disease Of Liver MetaADEDB
Drug Ineffective MetaADEDB
Drug Toxicity MetaADEDB
Dry Skin ADReCS
Ear Infection ADReCS
Educational Problem MetaADEDB
Enanthema ADReCS
Encephalopathy ADReCS
Encopresis MetaADEDB
Enlarged Liver MetaADEDB
Epistaxis ADReCS
Eye Pain ADReCS
Eye Redness MetaADEDB
Faecal Incontinence MetaADEDB
Faecaloma MetaADEDB
Fluid Overload MetaADEDB
Gastritis ADReCS
Gastroenteritis ADReCS
Gastrointestinal Bleed MetaADEDB
Gastrointestinal Haemorrhage ADReCS
Granulocytopenia PROTECT
Headache ADReCS
Henoch-Schonlein Purpura MetaADEDB
Hepatic Dysplasia MetaADEDB
Hepatic Enzyme MetaADEDB
Hepatic Enzyme Increased ADReCS
Hepatic Failure ADReCS
Hepatic Function Abnormal ADReCS
Hepatic Neoplasia MetaADEDB
Hepatic Neoplasm ADReCS
Hepatic Neoplasm Malignant MetaADEDB
Hepatic Neoplasm Malignant Resectable MetaADEDB
Hepatoblastoma MetaADEDB
Hepatomegaly ADReCS
Hepatorenal Failure MetaADEDB
Hepatosplenomegaly MetaADEDB
Hyperkeratosis PROTECT
Hyperkinesia ADReCS
Hypoglycaemia ADReCS
Hyporeflexia MetaADEDB
Hypotonia MetaADEDB
Increased Platelet Count MetaADEDB
Infection ADReCS
Infection Viral MetaADEDB
Intestinal Obstruction MetaADEDB
Itch MetaADEDB
Keratitis ADReCS
Learning Disorder MetaADEDB
Leukocytosis PROTECT
Leukopenia ADReCS
Liver Transplant MetaADEDB
Lymphoma MetaADEDB
Melaena ADReCS
Mental Retardation MetaADEDB
Metastases To Liver MetaADEDB
Microcephaly MetaADEDB
Mucosal Inflammation MetaADEDB
Multi-Organ Failure MetaADEDB
Neonatal Hypotension MetaADEDB
Neonatal Respiratory Failure MetaADEDB
Nervousness ADReCS
No Therapeutic Response MetaADEDB
Opisthotonus MetaADEDB
Pathological Fracture ADReCS
Peritonitis Bacterial MetaADEDB
Photophobia ADReCS
Platelet Count MetaADEDB
Polyneuropathy MetaADEDB
Porphyria ADReCS
Portal Hypertension MetaADEDB
Protein Total Decreased MetaADEDB
Prothrombin Level Increased MetaADEDB
Prothrombin Time Prolonged MetaADEDB
Pruritus ADReCS
Quadriparesis MetaADEDB
Rash Erythematous PROTECT
Rash Maculo-Papular ADReCS
Respiratory Failure ADReCS
Respiratory Rate Increased MetaADEDB
Rhagades MetaADEDB
Scrotal Swelling MetaADEDB
Sepsis ADReCS
Septicemia SIDER
Somnolence ADReCS
Speech Disorder Developmental MetaADEDB
Thirst ADReCS
Thrombocytopenia ADReCS
Tooth Discolouration ADReCS
Treatment Noncompliance MetaADEDB
Urine Delta Aminolevulinate Increased MetaADEDB

InAADR: Drug-Protein-ADRs database