InAADR

Drug Information

Drug Name: Nisoldipine (63675-72-9)
PubChem ID: 4499
SMILES: CC1=C(C(C(=C(N1)C)C(=O)OCC(C)C)C2=CC=CC=C2[N+](=O)[O-])C(=O)OC
InchiKey: VKQFCGNPDRICFG-UHFFFAOYSA-N
Therapeutic Category: Antihypertensive Agents, Calcium Channel Blockers, Cardiovascular Agents, Membrane Transport Modulators, Vasodilator Agents

Computed Drug Properties

Molecular Weight (dalton): 388.42
LogP: 3.2018
Ring Count: 1
Hydrogen Bond Acceptor Count: 7
Hydrogen Bond Donor Count: 1
Total Polar Surface Area: 107.77

This panel provides information on interacting drugs and their ADRs along with references

Interacting drug Toxicity Interaction Type Mechanism Reference

This panel provides drug-protein interaction and their ADRs along with references

Toxicity Interacting Protein Mechanism Reference

This panel provides information on metabolites and their ADRs along with references

Metabolite Toxicity Place of Metabolism Mechanism Reference

This panel provides information on drug category

Toxicity Source
Abdominal Discomfort MetaADEDB
Abdominal Distension MetaADEDB
Abnormal Dreams ADReCS
Abnormal Gait MetaADEDB
Abnormal Movements MetaADEDB
Accelerated Hypertension MetaADEDB
Aching Joints MetaADEDB
Aching Muscles MetaADEDB
Acid Reflux MetaADEDB
Acne ADReCS
Acute Coronary Syndrome ADReCS
Acute Kidney Injury MetaADEDB
Acute Respiratory Failure MetaADEDB
Adenopathy MetaADEDB
Adrenal Neoplasm MetaADEDB
Afib MetaADEDB
Agranulocytoses MetaADEDB
Alopecia ADReCS
Amblyopia ADReCS
Amnesia ADReCS
Anaemia ADReCS
Anaesthesia MetaADEDB
Angina Pectoris MetaADEDB
Angina Stable MetaADEDB
Angioedema ADReCS
Anhedonia MetaADEDB
Anhidrosis MetaADEDB
Anorexia ADReCS
Anosmia MetaADEDB
Anxiety ADReCS
Aortic Arteriosclerosis MetaADEDB
Aortic Regurgitation MetaADEDB
Aortic Stenosis MetaADEDB
Aphthous Stomatitis MetaADEDB
Apoplexy MetaADEDB
Arrhythmia MetaADEDB
Arterial Occlusive Disease MetaADEDB
Arteriosclerotic Heart Disease MetaADEDB
Arthralgia ADReCS
Arthritis ADReCS
Arthritis Bacterial MetaADEDB
Artificial Crown Procedure MetaADEDB
Aspartate Aminotransferase Increase MetaADEDB
Asthenia MetaADEDB
Asthma ADReCS
Ataxia ADReCS
Atelectasis MetaADEDB
Atherosclerosis MetaADEDB
Atrial Fibrillation ADReCS
Atrioventricular Block SIDER
Atrioventricular Block First Degree ADReCS
Atrophy MetaADEDB
Autoimmune Hepatitis MetaADEDB
Bacillus Infection MetaADEDB
Back Ache MetaADEDB
Balance Disorder MetaADEDB
Bile Duct Stenosis MetaADEDB
Biliary Dilatation MetaADEDB
Biliary Fibrosis MetaADEDB
Binocular Eye Movement Disorder MetaADEDB
Biopsy Gingival MetaADEDB
Birth Defect MetaADEDB
Bladder Cancer MetaADEDB
Bladder Operation MetaADEDB
Bleeding Gums MetaADEDB
Blepharitis ADReCS
Blindness ADReCS
Blood Calcium Increased MetaADEDB
Blood Creatine Phosphokinase Increased ADReCS
Blood Creatinine Increased ADReCS
Blood Culture Positive MetaADEDB
Blood In Urine MetaADEDB
Blood Lactate Dehydrogenase Increased MetaADEDB
Blood Potassium Decreased MetaADEDB
Blood Potassium Increased MetaADEDB
Blood Pressure Fluctuation MetaADEDB
Blood Pressure Inadequately Controlled MetaADEDB
Blood Pressure Systolic Increased MetaADEDB
Blood Sodium MetaADEDB
Blood Urea Increased ADReCS
Blood Uric Acid MetaADEDB
Bloody Discharge MetaADEDB
Body Height Decreased MetaADEDB
Body Temperature Increased ADReCS
Bone Disorder MetaADEDB
Bone Pain MetaADEDB
Bone Spur MetaADEDB
Bradycardia MetaADEDB
Brain Oedema MetaADEDB
Brain Stem Infarction MetaADEDB
Breath Sounds Abnormal MetaADEDB
Bronchopneumonia MetaADEDB
Bulging MetaADEDB
Calculus Ureteric MetaADEDB
Cardiac Decompensation MetaADEDB
Cardiac Disease MetaADEDB
Cardiac Enlargement MetaADEDB
Cardiac Failure ADReCS
Cardiac Failure Congestive ADReCS
Cardiac Fibrillation ADReCS
Cardiac Infection MetaADEDB
Cardiac Ischemia MetaADEDB
Cardiac Murmur ADReCS
Cardioactive Drug Level Increased MetaADEDB
Cardiomegaly MetaADEDB
Cardiomyopathy MetaADEDB
Cardiovascular Diseases MetaADEDB
Carotid Arteriosclerosis MetaADEDB
Carpal Tunnel MetaADEDB
Cartilage Development Disorder MetaADEDB
Cartilage Injury MetaADEDB
Cellulitis ADReCS
Cerebellar Haemorrhage MetaADEDB
Cerebral Ischaemia ADReCS
Cerebrovascular Accident ADReCS
Cervicalgia MetaADEDB
Chest Discomfort ADReCS
Chest Pain ADReCS
Chest Tightness ADReCS
Chill MetaADEDB
Chills ADReCS
Choking Sensation MetaADEDB
Cholangitis Sclerosing MetaADEDB
Cholecystitis MetaADEDB
Chronic Fatigue Syndrome MetaADEDB
Chronic Kidney Disease MetaADEDB
Chronic Left Ventricular Failure MetaADEDB
Chronic Obstructive Airway Disease MetaADEDB
Chronic Sinusitis MetaADEDB
Cold Sweat MetaADEDB
Colectomy MetaADEDB
Colitis ADReCS
Colon Operation MetaADEDB
Colon Spastic MetaADEDB
Colpitis MetaADEDB
Coma MetaADEDB
Communication Disorder MetaADEDB
Confusional State ADReCS
Congenital Mitral Valve Incompetence MetaADEDB
Conjunctivitis ADReCS
Constipated MetaADEDB
Coronary Artery Stenosis MetaADEDB
Coronary Disease MetaADEDB
Costochondritis MetaADEDB
Cough ADReCS
Cough Increased ADReCS
Cramp Muscle SIDER
Cramps Of Lower Extremities SIDER
Cushingoid MetaADEDB
Cutaneous Candidiasis MetaADEDB
Cutaneous Ulcer MetaADEDB
Cyst MetaADEDB
Debridement MetaADEDB
Decreased Appetite ADReCS
Decubitus Ulcer MetaADEDB
Deep Vein Thromboses MetaADEDB
Dementia Alzheimer Type MetaADEDB
Demyelination MetaADEDB
Dental Abscess MetaADEDB
Dental Pain MetaADEDB
Depression ADReCS
Dermatitis ADReCS
Dermatitis Exfoliative ADReCS
Detached Retina MetaADEDB
Detachment Psychological SIDER
Diabetes MetaADEDB
Diabetes Mellitus ADReCS
Diabetes Mellitus Non-Insulin-Dependent MetaADEDB
Diabetic Gastroparesis MetaADEDB
Diabetic Neuropathy MetaADEDB
Dialysis MetaADEDB
Diarrhea MetaADEDB
Diarrhoea ADReCS
Discomfort ADReCS
Disorder Renal MetaADEDB
Dissociation ADReCS
Disturbance In Sexual Arousal ADReCS
Diverticulum MetaADEDB
Dizziness ADReCS
Drug Administration Error MetaADEDB
Drug Hypersensitivity MetaADEDB
Drug Ineffective MetaADEDB
Drug Withdrawal Headache MetaADEDB
Dry Mouth ADReCS
Dry Skin ADReCS
Dysgeusia ADReCS
Dyspepsia ADReCS
Dysphagia ADReCS
Dyspnoea ADReCS
Dysstasia MetaADEDB
Dysuria ADReCS
Ear Ache MetaADEDB
Ear Congestion MetaADEDB
Ear Infection ADReCS
Ear Pain ADReCS
Eating Disorder MetaADEDB
Ecchymosis ADReCS
Ecg Signs Of Ventricular Hypertrophy MetaADEDB
Economic Problem MetaADEDB
Edema MetaADEDB
Edema Extremities MetaADEDB
Effusion ADReCS
Electrocardiogram Change MetaADEDB
Electrocardiogram Poor R-Wave Progression MetaADEDB
Electrocardiogram St Segment Abnormal MetaADEDB
Electrocardiogram T Wave Inversion MetaADEDB
Electromechanical Dissociation MetaADEDB
Emotional Distress MetaADEDB
Empyema MetaADEDB
Endotracheal Intubation Complication MetaADEDB
Enteritis MetaADEDB
Enterococcal Sepsis MetaADEDB
Enterocolitis MetaADEDB
Enterovesical Fistula MetaADEDB
Epistaxis ADReCS
Erectile Dysfunction ADReCS
Erythema MetaADEDB
Erythema Multiforme MetaADEDB
Escherichia Infection MetaADEDB
Esophageal Ulcer MetaADEDB
Excess Potassium MetaADEDB
Excessive Thirst MetaADEDB
Extrapyramidal Disorder MetaADEDB
Extrasystoles ADReCS
Extremity Contracture MetaADEDB
Extremity Pain MetaADEDB
Eye Pain MetaADEDB
Eye Pruritus ADReCS
Eye Swelling MetaADEDB
Eyelid Irritation MetaADEDB
Face Oedema ADReCS
Facial Flushing MetaADEDB
Facial Palsy MetaADEDB
Faeces Discoloured MetaADEDB
Fat Tissue Increased MetaADEDB
Fatigue MetaADEDB
Fear Of Falling MetaADEDB
Feeling Abnormal ADReCS
Fib MetaADEDB
Fibroids MetaADEDB
Fibrous Histiocytoma MetaADEDB
Fibula Fracture MetaADEDB
Flatulence ADReCS
Fluid Overload MetaADEDB
Flushing MetaADEDB
Foot Fracture MetaADEDB
Formication MetaADEDB
Fungal Skin Infection ADReCS
Gambling MetaADEDB
Gangrene MetaADEDB
Gastric Disorder MetaADEDB
Gastritis ADReCS
Gastrointestinal Haemorrhage ADReCS
Gastrointestinal Sounds Abnormal MetaADEDB
Gingival Disorder MetaADEDB
Gingival Hyperplasia ADReCS
Gingival Oedema MetaADEDB
Glaucoma ADReCS
Glossitis ADReCS
Gout ADReCS
Gynaecomastia ADReCS
Haematuria ADReCS
Haemodialysis MetaADEDB
Haemodynamic Instability MetaADEDB
Haemoglobin ADReCS
Haemorrhage ADReCS
Haemorrhage Intracranial MetaADEDB
Haemorrhage Rectum MetaADEDB
Hair Growth Abnormal MetaADEDB
Headache ADReCS
Heart Attack MetaADEDB
Heart Failure MetaADEDB
Heart Injury MetaADEDB
Heart Valve Replacement MetaADEDB
Helicobacter Gastritis MetaADEDB
Hemiplegia MetaADEDB
Hepatic Function Abnormal ADReCS
Hepatic Neoplasm Malignant MetaADEDB
Hepatocellular Damage MetaADEDB
Hepatomegaly ADReCS
Herpes Nos SIDER
Herpes Simplex ADReCS
Herpes Virus Infection ADReCS
Herpes Zoster ADReCS
Homocystinaemia MetaADEDB
Hyperalimentation MetaADEDB
Hyperhidrosis ADReCS
Hyperlipaemia MetaADEDB
Hyperplasia ADReCS
Hypersensitivity ADReCS
Hypertension ADReCS
Hypertonia ADReCS
Hypoaesthesia ADReCS
Hypoaesthesia Oral MetaADEDB
Hypokalaemia ADReCS
Hypophagia MetaADEDB
Hypoproteinaemia MetaADEDB
Hypotension ADReCS
Hypoxia MetaADEDB
Ill-Defined Disorder ADReCS
Impaired Healing MetaADEDB
Impingement Syndrome MetaADEDB
Implantable Defibrillator Insertion MetaADEDB
Impotence ADReCS
Incoherent MetaADEDB
Increased Appetite ADReCS
Infarction ADReCS
Infection Urinary Tract MetaADEDB
Influenza ADReCS
Inner Ear Inflammation MetaADEDB
Insomnia ADReCS
International Normalised Ratio Decreased MetaADEDB
Intervertebral Disc Degeneration MetaADEDB
Intervertebral Disc Herniation MetaADEDB
Intervertebral Disc Space Narrowing MetaADEDB
Intestinal Diseases MetaADEDB
Intraocular Pressure Decreased MetaADEDB
Ischaemia ADReCS
Ischemia MetaADEDB
Itch MetaADEDB
Jaw Operation MetaADEDB
Joint Contracture MetaADEDB
Joint Stiffness MetaADEDB
Jugular Vein Distension ADReCS
Keratitis ADReCS
Keratoconjunctivitis SIDER
Kidney Failure MetaADEDB
Lacrimation Increased ADReCS
Lacunar Infarction MetaADEDB
Large Intestinal Ulcer MetaADEDB
Laryngitis ADReCS
Left Ventricular Hypertrophy MetaADEDB
Leg Cramps ADReCS
Lethargy MetaADEDB
Leucopenia MetaADEDB
Leukopenia ADReCS
Libido Decreased ADReCS
Life Expectancy Shortened MetaADEDB
Limb Discomfort MetaADEDB
Lip Blister MetaADEDB
Liver Function Test Abnormal ADReCS
Local Swelling MetaADEDB
Loss Of Consciousness ADReCS
Lung Fibrosis MetaADEDB
Lung Infiltration MetaADEDB
Lymphocytosis MetaADEDB
Macular Oedema MetaADEDB
Malaise ADReCS
Maxillofacial Operation MetaADEDB
Melaena ADReCS
Mental Disability ADReCS
Microangiopathic Haemolytic Anaemia MetaADEDB
Migraine ADReCS
Mitral Valve Disease MetaADEDB
Monarthritis MetaADEDB
Mouth Pain MetaADEDB
Mouth Ulcer MetaADEDB
Mouth Ulceration ADReCS
Multiple Allergies MetaADEDB
Multiple Injuries MetaADEDB
Multiple Myeloma MetaADEDB
Muscle Necrosis MetaADEDB
Muscle Spasms ADReCS
Muscle Weakness MetaADEDB
Muscular Weakness ADReCS
Musculoskeletal Discomfort ADReCS
Musculoskeletal Pain MetaADEDB
Musculoskeletal Stiffness MetaADEDB
Myalgia ADReCS
Myasthenia SIDER
Myocardial Infarction ADReCS
Myocardial Ischemia MetaADEDB
Myositis ADReCS
Nasopharyngitis MetaADEDB
Nausea ADReCS
Near Syncope MetaADEDB
Nephrolithiasis MetaADEDB
Nervousness ADReCS
Neumonia MetaADEDB
Neurosis MetaADEDB
Neutrophil Count Decreased MetaADEDB
Nocturia ADReCS
Non-Cardiac Chest Pain MetaADEDB
Normochromic Normocytic Anaemia MetaADEDB
Oedema ADReCS
Oedema Peripheral ADReCS
Oesophageal Ulcer Haemorrhage MetaADEDB
Oliguria MetaADEDB
Oral Fungal Infection MetaADEDB
Oral Herpes MetaADEDB
Orchitis MetaADEDB
Oropharyngeal Pain MetaADEDB
Orthopnea MetaADEDB
Orthostatic Hypotension ADReCS
Osteoarthritis MetaADEDB
Osteopenia MetaADEDB
Osteoporosis MetaADEDB
Otitis SIDER
Otitis Media ADReCS
Pain ADReCS
Pain Pelvic MetaADEDB
Pallor MetaADEDB
Palpitation MetaADEDB
Palpitations ADReCS
Pancreatitis Chronic MetaADEDB
Paraesthesia ADReCS
Parkinson MetaADEDB
Periarthritis MetaADEDB
Petechiae ADReCS
Pharyngitis ADReCS
Photosensitivity SIDER
Photosensitivity Reaction ADReCS
Pickwickian Syndrome MetaADEDB
Plasmacytoma MetaADEDB
Plasmacytosis MetaADEDB
Pleural Disorder ADReCS
Pleural Effusion ADReCS
Pleurisy MetaADEDB
Pneumonia Viral MetaADEDB
Pollakiuria ADReCS
Polymyalgia Rheumatica MetaADEDB
Post Nasal Drip MetaADEDB
Post Procedural Complication MetaADEDB
Post Procedural Oedema MetaADEDB
Postmenopausal Bleeding MetaADEDB
Postoperative Wound Complication MetaADEDB
Presbyopia MetaADEDB
Prescribed Overdose MetaADEDB
Procedural Pain MetaADEDB
Prothrombin Time Abnormal MetaADEDB
Prothrombin Time Prolonged MetaADEDB
Pruritus ADReCS
Pruritus Generalised MetaADEDB
Psoriasis MetaADEDB
Pulmonary Valve Incompetence MetaADEDB
Purulence MetaADEDB
Pyrexia ADReCS
Rales ADReCS
Rash ADReCS
Rash Generalised MetaADEDB
Rash Maculo-Papular ADReCS
Rash Pustular ADReCS
Respiration Abnormal MetaADEDB
Respiratory Tract Congestion MetaADEDB
Retinal Bleeding MetaADEDB
Retinal Detachment ADReCS
Reversible Posterior Leukoencephalopathy Syndrome MetaADEDB
Rhagades MetaADEDB
Rhinitis ADReCS
Road Traffic Accident MetaADEDB
Scoliosis MetaADEDB
Scotoma MetaADEDB
Scrotal Swelling MetaADEDB
Sensation Of Heaviness MetaADEDB
Shock ADReCS
Sick Sinus Syndrome MetaADEDB
Silent Myocardial Infarction MetaADEDB
Sinus Disorder MetaADEDB
Sinusitis ADReCS
Skin Discolouration ADReCS
Skin Hypertrophy MetaADEDB
Skin Necrosis MetaADEDB
Skin Odour Abnormal MetaADEDB
Skin Tightness MetaADEDB
Skin Ulcer ADReCS
Sleep Apnea MetaADEDB
Sleep Disorder MetaADEDB
Small Bowel Angioedema MetaADEDB
Small Intestinal Obstruction MetaADEDB
Soft Tissue Necrosis MetaADEDB
Somnolence ADReCS
Speech Disorder MetaADEDB
Spinal Disorder MetaADEDB
Spinal Osteoarthritis MetaADEDB
Spinning Sensation MetaADEDB
Spleen Disorder MetaADEDB
Spondylolisthesis MetaADEDB
Spondylosis MetaADEDB
Staphylococcal Infection MetaADEDB
Stomatitis ADReCS
Stress MetaADEDB
Supraventricular Tachycardia ADReCS
Surgery MetaADEDB
Sweating SIDER
Swollen Tongue MetaADEDB
Syncope ADReCS
Systolic Ejection Murmur SIDER
Tachycardia ADReCS
Tenosynovitis ADReCS
Tension ADReCS
Thinking Abnormal ADReCS
Thrombosis MetaADEDB
Thyroiditis ADReCS
Tinnitus ADReCS
Tooth Disease MetaADEDB
Tooth Extraction MetaADEDB
Transient Ischaemic Attack MetaADEDB
Treatment Noncompliance MetaADEDB
Tremor ADReCS
Ulcer ADReCS
Unevaluable Event MetaADEDB
Unresponsive To Stimuli MetaADEDB
Urticaria ADReCS
Uterine Cancer MetaADEDB
Uterine Prolapse MetaADEDB
Vaginal Haemorrhage ADReCS
Vaginal Infection ADReCS
Vaginal Inflammation ADReCS
Vasodilation SIDER
Vasodilation Procedure ADReCS
Venous Insufficiency ADReCS
Ventricular Dysfunction Left MetaADEDB
Ventricular Extrasystoles ADReCS
Vertigo ADReCS
Visual Acuity Reduced ADReCS
Visual Disturbance MetaADEDB
Visual Impairment ADReCS
Vitamin B 12 Deficiency MetaADEDB
Vitreous Floaters ADReCS
Walking Aid User MetaADEDB
Weight Decreased ADReCS
Weight Gain MetaADEDB
Weight Increased ADReCS
Wheezing ADReCS
Wheezing Inspiratory SIDER
Wound Drainage MetaADEDB
Wound Necrosis MetaADEDB

InAADR: Drug-Protein-ADRs database