InAADR

Drug Information

Drug Name: Nalidixic Acid (389-08-2)
PubChem ID: 4421
SMILES: CCN1C=C(C(=O)C2=C1N=C(C=C2)C)C(=O)O
InchiKey: MHWLWQUZZRMNGJ-UHFFFAOYSA-N
Therapeutic Category: Anti-Bacterial Agents, Anti-Infective Agents, Antineoplastic Agents, Enzyme Inhibitors, Nucleic Acid Synthesis Inhibitors, Topoisomerase II Inhibitors, Topoisomerase Inhibitors

Computed Drug Properties

Molecular Weight (dalton): 232.239
LogP: 1.42302
Ring Count: 2
Hydrogen Bond Acceptor Count: 4
Hydrogen Bond Donor Count: 1
Total Polar Surface Area: 72.19

This panel provides information on interacting drugs and their ADRs along with references

Interacting drug Toxicity Interaction Type Mechanism Reference
Acenocoumarol (152-72-7) Bleeding Antagonistic Uncertain. It is not clear what factors might have been responsible in those cases where the effects of the anticoagulants were increased. nalidixic acid can displace acenocoumarol from its binding sites on human plasma albumin, but this mechanism on its own is almost certainly not the full explanation Nicoumalone and nalidixic acid interaction
Warfarin (81-81-2) Bleeding Antagonistic Uncertain. It is not clear what factors might have been responsible in those cases where the effects of the anticoagulants were increased Letter: Interaction of nalidixic acid and warfarin

This panel provides drug-protein interaction and their ADRs along with references

Toxicity Interacting Protein Mechanism Reference

This panel provides drug-food interactions and their ADRs along with references

Food Toxicity Reference

This panel provides information on metabolites and their ADRs along with references

Metabolite Toxicity Place of Metabolism Mechanism Reference

This panel provides information on drug category

Toxicity Source
Abdominal Pain ADReCS
Abducens Nerve Diseases MetaADEDB
Acid-Base Imbalance MetaADEDB
Acidosis ADReCS
Anaemia ADReCS
Anaphylactic Shock ADReCS
Anaphylactoid Reaction ADReCS
Anemia Hemolytic MetaADEDB
Anemia Hemolytic Autoimmune MetaADEDB
Angioedema ADReCS
Arteriosclerosis ADReCS
Arthralgia ADReCS
Asthenia ADReCS
Blister ADReCS
Cerebral Arteriosclerosis ADReCS
Cholestasis ADReCS
Cochlear Diseases MetaADEDB
Colour Blindness Acquired ADReCS
Confusion MetaADEDB
Convulsion ADReCS
Cranial Nerve Paralysis ADReCS
Dermatitis ADReCS
Dermatitis Bullous ADReCS
Diarrhoea ADReCS
Diplopia ADReCS
Disturbance In Attention ADReCS
Dizziness ADReCS
Drowsiness SIDER
Drug-Induced Liver Injury MetaADEDB
Dysentery MetaADEDB
Dysentery Bacillary MetaADEDB
Eosinophilia ADReCS
Epilepsy ADReCS
Epilepsy Tonic-Clonic MetaADEDB
Erythema ADReCS
Erythema Multiforme ADReCS
Eye Diseases MetaADEDB
Fontanelle Bulging ADReCS
Gastrointestinal Pain ADReCS
Glucose-6-Phosphate Dehydrogenase Deficiency ADReCS
Haemolytic Anaemia ADReCS
Hallucinations MetaADEDB
Headache ADReCS
Hyperglycemia MetaADEDB
Intracranial Hypertension MetaADEDB
Intracranial Pressure Increased ADReCS
Jaundice MetaADEDB
Joint Stiffness ADReCS
Kidney Diseases MetaADEDB
Left Atrial Dilatation ADReCS
Left Atrial Hypertrophy ADReCS
Leukopenia ADReCS
Metabolic Acidosis ADReCS
Muscular Diseases MetaADEDB
Muscular Weakness ADReCS
Musculoskeletal Discomfort ADReCS
Musculoskeletal Stiffness ADReCS
Nausea ADReCS
Nerve Paralysis SIDER
Neuropathy ADReCS
Neuropathy Peripheral ADReCS
Optic Neuritis ADReCS
Overdose MetaADEDB
Pain ADReCS
Papilledema MetaADEDB
Papilloedema ADReCS
Paraesthesia ADReCS
Paralysis ADReCS
Peripheral Sensory Neuropathy ADReCS
Photophobia ADReCS
Photosensitivity SIDER
Photosensitivity Reaction ADReCS
Pruritus ADReCS
Pseudotumor Cerebri MetaADEDB
Psychoses Substance-Induced MetaADEDB
Psychotic Disorder ADReCS
Rash ADReCS
Respiration Disorders MetaADEDB
Seizures MetaADEDB
Shock ADReCS
Somnolence ADReCS
Stevens-Johnson Syndrome ADReCS
Stiffness SIDER
Strabismus MetaADEDB
Subjective Visual Disturbances SIDER
Swelling ADReCS
Thrombocytopenia ADReCS
Unconsciousness MetaADEDB
Urinary Tract Infections MetaADEDB
Urologic Diseases MetaADEDB
Urticaria ADReCS
Vertigo ADReCS
Visual Acuity Reduced ADReCS
Visual Disturbance ADReCS
Visual Impairment ADReCS
Vith Nerve Paralysis ADReCS
Vomiting ADReCS
Weakness SIDER

InAADR: Drug-Protein-ADRs database