InAADR

Drug Information

Drug Name: Mitotane (53-19-0)
PubChem ID: 4211
SMILES: C1=CC=C(C(=C1)C(C2=CC=C(C=C2)Cl)C(Cl)Cl)Cl
InchiKey: JWBOIMRXGHLCPP-UHFFFAOYSA-N
Therapeutic Category: Antineoplastic Agents

Computed Drug Properties

Molecular Weight (dalton): 320.046
LogP: 5.929
Ring Count: 2
Hydrogen Bond Acceptor Count: 0
Hydrogen Bond Donor Count: 0
Total Polar Surface Area: 0

This panel provides information on interacting drugs and their ADRs along with references

Interacting drug Toxicity Interaction Type Mechanism Reference

This panel provides drug-protein interaction and their ADRs along with references

Toxicity Interacting Protein Mechanism Reference

This panel provides drug-food interactions and their ADRs along with references

Food Toxicity Reference

This panel provides information on metabolites and their ADRs along with references

Metabolite Toxicity Place of Metabolism Mechanism Reference

This panel provides information on drug category

Toxicity Source
Abnormal Gait MetaADEDB
Abnormal Lfts MetaADEDB
Accidental Exposure MetaADEDB
Ache SIDER
Aching Muscles MetaADEDB
Acute Kidney Failure MetaADEDB
Adrenal Cortex Diseases MetaADEDB
Adrenal Gland Cancer Metastatic MetaADEDB
Adrenal Gland Neoplasms MetaADEDB
Adrenal Insufficiency PROTECT
Adrenocortical Carcinoma MetaADEDB
Aggression PROTECT
Agitated MetaADEDB
Alanine Aminotransferase Abnormal MetaADEDB
Albuminuria ADReCS
Alopecia MetaADEDB
Amnesia MetaADEDB
Anaemia PROTECT
Anorexia ADReCS
Antiviral Drug Level Above Therapeutic MetaADEDB
Aplasia Pure Red Cell MetaADEDB
Asthenia PROTECT
Ataxia PROTECT
Autoimmune Hepatitis PROTECT
Balance Disorder PROTECT
Bile Duct Obstruction MetaADEDB
Bile Duct Stone MetaADEDB
Bladder Pain ADReCS
Bleeding Time Prolonged PROTECT
Blood Alkaline Phosphatase Abnormal MetaADEDB
Blood Alkaline Phosphatase Increased MetaADEDB
Blood Cholesterol Increased PROTECT
Blood Coagulation Disorders MetaADEDB
Blood Cortisol Increased MetaADEDB
Blood Count Abnormal MetaADEDB
Blood Lactate Dehydrogenase Increased MetaADEDB
Blood Potassium Decreased MetaADEDB
Blood Triglycerides Increased PROTECT
Blood Uric Acid Decreased PROTECT
Bone Density Increased MetaADEDB
Bone Fracture Spontaneous MetaADEDB
Bruise MetaADEDB
Central Nervous System Diseases MetaADEDB
Cerebellar Ataxia MetaADEDB
Cerebral Thrombosis MetaADEDB
Chemotherapeutic Drug Level Increased MetaADEDB
Cholestatic Liver Injury PROTECT
Condition Aggravated MetaADEDB
Confabulation MetaADEDB
Confusional State PROTECT
Cushing Syndrome MetaADEDB
Cystitis ADReCS
Cystitis Haemorrhagic ADReCS
Cystitis Noninfective ADReCS
Cytolytic Hepatitis MetaADEDB
Decreased Appetite ADReCS
Dehydroepiandrosterone Decreased MetaADEDB
Demyelination MetaADEDB
Depression ADReCS
Dermatitis ADReCS
Diarrhea MetaADEDB
Diarrhoea ADReCS
Diplopia ADReCS
Disease Of Liver MetaADEDB
Disturbance In Attention MetaADEDB
Dizziness ADReCS
Drowsiness MetaADEDB
Drug Level Below Therapeutic MetaADEDB
Drug Toxicity MetaADEDB
Drug-Induced Liver Injury MetaADEDB
Dysarthria PROTECT
Dysgeusia PROTECT
Dyspepsia PROTECT
Emesis MetaADEDB
Encephalopathy PROTECT
Eosinophil Count Increased MetaADEDB
Epigastric Discomfort PROTECT
Erectile Dysfunction MetaADEDB
Eruption MetaADEDB
Exanthema MetaADEDB
Excess Potassium MetaADEDB
Febrile Neutropenia MetaADEDB
Flushing ADReCS
Formication MetaADEDB
Fungal Infection PROTECT
Gastrointestinal Bleed MetaADEDB
Gastrointestinal Diseases MetaADEDB
General Physical Health Deterioration MetaADEDB
Generalized Aching SIDER
Globulinuria MetaADEDB
Growth Retardation PROTECT
Gynaecomastia PROTECT
Haematuria ADReCS
Headache PROTECT
Hemorrhage MetaADEDB
Hepatic Enzyme MetaADEDB
Hepatic Enzyme Increased PROTECT
Hepatitis B Positive MetaADEDB
Hepatocellular Injury PROTECT
Hypercholesterolaemia PROTECT
Hyperpyrexia ADReCS
Hypertension ADReCS
Hypertriglyceridaemia PROTECT
Hypogonadism MetaADEDB
Hypokalaemia MetaADEDB
Hypotension ADReCS
Hypothyroid MetaADEDB
Hypothyroidism PROTECT
Hypouricaemia PROTECT
Hypovolaemic Shock MetaADEDB
Ichthyosis ADReCS
Ichthyosis Acquired ADReCS
Increased Platelet Count MetaADEDB
Irritation Skin MetaADEDB
Jaundice MetaADEDB
Kidney Failure MetaADEDB
Kidney Infection MetaADEDB
Language Disorders MetaADEDB
Lens Disorder ADReCS
Lenticular Opacities ADReCS
Lethargy ADReCS
Leucopenia MetaADEDB
Leukopenia PROTECT
Leukopenia Neonatal MetaADEDB
Liver Injury PROTECT
Long Qt Syndrome MetaADEDB
Loss Of Weight MetaADEDB
Lymphocytes Decreased MetaADEDB
Maculopathy PROTECT
Malignant Neoplasm Progression MetaADEDB
Memory Disorders MetaADEDB
Memory Impairment PROTECT
Mental Disorders MetaADEDB
Mental Impairment PROTECT
Mental Retardation PROTECT
Metastases To Liver MetaADEDB
Movement Disorder PROTECT
Mucosal Inflammation PROTECT
Muscle Weakness MetaADEDB
Muscular Weakness PROTECT
Nausea ADReCS
Necrosis MetaADEDB
Neoplasm Progression MetaADEDB
Neurological Examination Abnormal MetaADEDB
Neuromuscular Manifestations MetaADEDB
Neuropathic Pain MetaADEDB
Neutrophil Count Decreased MetaADEDB
Orthostatic Hypotension ADReCS
Overdose MetaADEDB
Pain ADReCS
Pain Pelvic MetaADEDB
Paraesthesia PROTECT
Parapharyngeal Abscess MetaADEDB
Parkinsonism PROTECT
Pelvic Venous Thrombosis MetaADEDB
Performance Status Decreased MetaADEDB
Peripheral Nervous System Diseases MetaADEDB
Pituitary Acth Hypersecretion MetaADEDB
Platelet Count MetaADEDB
Polyneuropathy PROTECT
Protein Bound Iodine Decreased ADReCS
Proteinuria PROTECT
Pseudotumor Cerebri MetaADEDB
Rash ADReCS
Renal Impairment MetaADEDB
Retinal Disorder ADReCS
Retinal Toxicity PROTECT
Retinopathy ADReCS
Salivary Hypersecretion PROTECT
Shock Haemorrhagic MetaADEDB
Skin Toxicity ADReCS
Sleep Apnea MetaADEDB
Sleep Disorder MetaADEDB
Somnolence ADReCS
Speech Disorder MetaADEDB
Spinning Sensation MetaADEDB
Stevens-Johnson Syndrome MetaADEDB
Sudden Death MetaADEDB
Thrombocytopenia PROTECT
Transaminases Increased MetaADEDB
Traumatic Fracture MetaADEDB
Tremor MetaADEDB
Tumour Necrosis MetaADEDB
Vena Cava Thrombosis MetaADEDB
Vertigo ADReCS
Vestibular Disorder PROTECT
Vision Blurred ADReCS
Visual Disturbance MetaADEDB
Visual Impairment PROTECT
Vomiting ADReCS

InAADR: Drug-Protein-ADRs database