InAADR

Drug Information

Drug Name: Lubiprostone (136790-76-6)
PubChem ID: 22055035
SMILES: CCCCC(C1(CCC2C(O1)CC(=O)C2CCCCCCC(=O)O)O)(F)F
InchiKey: WGFOBBZOWHGYQH-UHFFFAOYSA-N
Therapeutic Category: Chloride Channel Agonists, Membrane Transport Modulators

Computed Drug Properties

Molecular Weight (dalton): 390.467
LogP: 4.3099
Ring Count: 0
Hydrogen Bond Acceptor Count: 4
Hydrogen Bond Donor Count: 2
Total Polar Surface Area: 83.83

This panel provides information on interacting drugs and their ADRs along with references

Interacting drug Toxicity Interaction Type Mechanism Reference

This panel provides drug-protein interaction and their ADRs along with references

Toxicity Interacting Protein Mechanism Reference

This panel provides drug-food interactions and their ADRs along with references

Food Toxicity Reference

This panel provides information on metabolites and their ADRs along with references

Metabolite Toxicity Place of Metabolism Mechanism Reference

This panel provides information on drug category

Toxicity Source
Abdominal Adhesions MetaADEDB
Abdominal Discomfort ADReCS
Abdominal Distension SIDER
Abdominal Distension ADReCS
Abdominal Hernia MetaADEDB
Abdominal Pain ADReCS
Abdominal Pain ADReCS
Abdominal Pain ADReCS
Abdominal Rigidity ADReCS
Abdominal Tenderness ADReCS
Abnormal Bowel Sounds SIDER
Abnormal Ecg MetaADEDB
Abnormal Gait MetaADEDB
Abnormal Loss Of Weight MetaADEDB
Abnormal Movements MetaADEDB
Abscess Oral MetaADEDB
Acantholysis MetaADEDB
Accident MetaADEDB
Acid Reflux MetaADEDB
Actinomycosis MetaADEDB
Activated Partial Thromboplastin Time Prolonged MetaADEDB
Activities Of Daily Living Impaired MetaADEDB
Acute Kidney Failure MetaADEDB
Acute Phase Reaction MetaADEDB
Acute Respiratory Distress Syndrome MetaADEDB
Adenoma Benign ADReCS
Administration Site Pain MetaADEDB
Adnexitis MetaADEDB
Adrenal Mass MetaADEDB
Agraphia MetaADEDB
Alanine Aminotransferase Increased ADReCS
Altered Bowel Function MetaADEDB
Altered State Of Consciousness MetaADEDB
Alveoloplasty MetaADEDB
Amnesia MetaADEDB
Anaemia Of Chronic Disease MetaADEDB
Anaemia Of Malignant Disease MetaADEDB
Angiopathy ADReCS
Anhedonia MetaADEDB
Anhidrosis MetaADEDB
Anorexia ADReCS
Anticonvulsant Drug Level Decreased MetaADEDB
Anxiety ADReCS
Aortic Aneurysm SIDER
Aortic Dissection SIDER
Application Site Erythema MetaADEDB
Application Site Nodule MetaADEDB
Arterial Pressure Nos Decreased MetaADEDB
Arthralgia ADReCS
Arthritis MetaADEDB
Aseptic Necrosis Bone MetaADEDB
Aspartate Aminotransferase Increased ADReCS
Assisted Fertilisation ADReCS
Asteatosis MetaADEDB
Asthenia ADReCS
Asthma ADReCS
Atrial Tachycardia MetaADEDB
Atrioventricular Block First Degree MetaADEDB
Atrophy MetaADEDB
Attempted Suicide MetaADEDB
Aura MetaADEDB
Azotaemia MetaADEDB
Back Ache MetaADEDB
Back Injury MetaADEDB
Back Pain ADReCS
Bacteraemia MetaADEDB
Bedridden MetaADEDB
Belching MetaADEDB
Benign Tumour Excision MetaADEDB
Biopsy Liver Abnormal MetaADEDB
Birth Defect MetaADEDB
Bite MetaADEDB
Bladder Inflammation MetaADEDB
Bladder Operation MetaADEDB
Bleeding Gums MetaADEDB
Blindness Transient MetaADEDB
Blindness Unilateral MetaADEDB
Blood Cholesterol MetaADEDB
Blood Chromogranin A Increased MetaADEDB
Blood Parathyroid Hormone Increased MetaADEDB
Blood Potassium Decreased MetaADEDB
Blood Pressure Systolic Increased MetaADEDB
Blood Prolactin Increased MetaADEDB
Blurred Vision MetaADEDB
Body Temperature Increased ADReCS
Bone Cancer Metastatic MetaADEDB
Bone Debridement MetaADEDB
Bone Density Decreased MetaADEDB
Bone Disorder MetaADEDB
Bone Erosion MetaADEDB
Bone Fragmentation MetaADEDB
Bone Lesion MetaADEDB
Bone Neoplasm Malignant MetaADEDB
Bone Pain MetaADEDB
Bone Scan Abnormal MetaADEDB
Bone Spur MetaADEDB
Borborygmi SIDER
Bowel Movement Irregularity MetaADEDB
Brain Oedema MetaADEDB
Breast Cancer Metastatic MetaADEDB
Breast Cancer Recurrent MetaADEDB
Breast Feeding ADReCS
Bronchitis ADReCS
Bulging MetaADEDB
Bundle Branch Block Right MetaADEDB
Burning Sensation Mucosal MetaADEDB
Carcinogenicity SIDER
Carcinoid Tumour MetaADEDB
Carcinoid Tumour Of The Appendix MetaADEDB
Cardiac Decompensation MetaADEDB
Cardiac Enlargement MetaADEDB
Cardiac Enzymes Increased MetaADEDB
Cardiac Valve Vegetation MetaADEDB
Cardiomyopathy MetaADEDB
Carotid Artery Disease MetaADEDB
Carotid Artery Stenosis MetaADEDB
Cellulitis MetaADEDB
Central Nervous System Inflammation MetaADEDB
Central Venous Catheter Removal MetaADEDB
Central Venous Catheterisation MetaADEDB
Cerebral Artery Embolism MetaADEDB
Cerebral Artery Occlusion MetaADEDB
Cerebral Artery Thrombosis MetaADEDB
Cerebral Atrophy MetaADEDB
Cervical Discharge MetaADEDB
Cervicalgia MetaADEDB
Chest Discomfort ADReCS
Chest Pain ADReCS
Chill MetaADEDB
Chills ADReCS
Choking Sensation MetaADEDB
Chronic Sinusitis MetaADEDB
Clavicle Fracture MetaADEDB
Clumsiness MetaADEDB
Coated Tongue MetaADEDB
Cognitive Disorder MetaADEDB
Cold Sweat ADReCS
Colitis MetaADEDB
Colitis Ischaemic MetaADEDB
Colon Spastic MetaADEDB
Colpitis MetaADEDB
Congenital Mitral Valve Incompetence MetaADEDB
Congestive Cardiomyopathy MetaADEDB
Connective Tissue Disorder SIDER
Constipated MetaADEDB
Constipation ADReCS
Cough ADReCS
Cramp Muscle SIDER
Csf Protein MetaADEDB
Cyst MetaADEDB
Decreased Appetite ADReCS
Decubitus Ulcer MetaADEDB
Defaecation Urgency ADReCS
Deglutition Disorder MetaADEDB
Dehydration MetaADEDB
Dental Abscess MetaADEDB
Dental Fistula MetaADEDB
Dental Prosthesis Placement MetaADEDB
Depression ADReCS
Dermatitides MetaADEDB
Dermatitis ADReCS
Dermatosis MetaADEDB
Device Related Infection MetaADEDB
Diarrhea MetaADEDB
Diarrhoea ADReCS
Diplopia MetaADEDB
Discomfort ADReCS
Disorder Lung MetaADEDB
Disorder Renal MetaADEDB
Diverticulum MetaADEDB
Dizziness ADReCS
Dizziness Exertional MetaADEDB
Drug Administration Error MetaADEDB
Drug Exposure During Pregnancy MetaADEDB
Drug Hypersensitivity MetaADEDB
Drug Interaction SIDER
Drug Tolerance MetaADEDB
Drug Withdrawal Headache MetaADEDB
Dry Mouth ADReCS
Duodenal Ulcer MetaADEDB
Dysgeusia ADReCS
Dyspepsia ADReCS
Dyspnea Exertional MetaADEDB
Dyspnoea ADReCS
Early Morning Awakening MetaADEDB
Early Satiety MetaADEDB
Economic Problem MetaADEDB
Eczema MetaADEDB
Edema Extremities MetaADEDB
Ejection Fraction Decreased MetaADEDB
Electrocardiogram Change MetaADEDB
Electrolyte Imbalance ADReCS
Embolic Stroke MetaADEDB
Emesis MetaADEDB
Emotional Disorder MetaADEDB
Emotional Distress MetaADEDB
Endocarditis MetaADEDB
Endodontic Procedure MetaADEDB
Epistaxis MetaADEDB
Eructation ADReCS
Eruption MetaADEDB
Erythema ADReCS
Erythema Annulare MetaADEDB
Essential Hypertension MetaADEDB
Excessive Granulation Tissue MetaADEDB
Extremity Pain MetaADEDB
Eye Pain MetaADEDB
Face Injury MetaADEDB
Facial Flushing MetaADEDB
Facial Neuralgia MetaADEDB
Faecal Incontinence ADReCS
Faeces Hard ADReCS
Family Stress MetaADEDB
Fatigue ADReCS
Feeling Abnormal ADReCS
Fertilization SIDER
Fib MetaADEDB
Fibroids MetaADEDB
Fibroma MetaADEDB
Fibromyalgia ADReCS
Fibrous Histiocytoma MetaADEDB
Fistula MetaADEDB
Flatulence ADReCS
Fluid Overload MetaADEDB
Flushing ADReCS
Formication MetaADEDB
Frequent Bowel Movements ADReCS
Gallbladder Cancer MetaADEDB
Gastric Bypass MetaADEDB
Gastric Dilatation MetaADEDB
Gastric Disorder ADReCS
Gastric Ulcer MetaADEDB
Gastritis ADReCS
Gastroenteritis ADReCS
Gastrointestinal Discomfort ADReCS
Gastrointestinal Disorder SIDER
Gastrointestinal Infection MetaADEDB
Gastrointestinal Pain ADReCS
Gastrointestinal Sounds Abnormal ADReCS
Gastrooesophageal Reflux Disease ADReCS
Genital Pain MetaADEDB
Gingival Graft MetaADEDB
Gingival Oedema MetaADEDB
Granuloma MetaADEDB
Gynaecomastia MetaADEDB
Haematemesis MetaADEDB
Haemoglobin ADReCS
Haemorrhage ADReCS
Haemothorax MetaADEDB
Hand-Foot-And-Mouth Disease MetaADEDB
Headache ADReCS
Heart Rate Increased ADReCS
Hematoma Subdural MetaADEDB
Hepatic Adenoma ADReCS
Hepatic Impairment ADReCS
Hepatocellular Adenoma SIDER
Hesitancy MetaADEDB
High Blood Pressure MetaADEDB
High Frequency Ablation MetaADEDB
Hip Arthroplasty MetaADEDB
Hip Fracture MetaADEDB
Hot Flush ADReCS
Hydronephrosis MetaADEDB
Hyperbaric Oxygen Therapy MetaADEDB
Hyperhidrosis ADReCS
Hyperkeratosis MetaADEDB
Hyperlipaemia MetaADEDB
Hyperparathyroidism MetaADEDB
Hypersensitivity ADReCS
Hypertension ADReCS
Hypertonia MetaADEDB
Hypoaesthesia ADReCS
Hypoaesthesia Facial MetaADEDB
Hypoalbuminaemia MetaADEDB
Hypophagia MetaADEDB
Hypovolaemia MetaADEDB
Ichthyosis MetaADEDB
Ill-Defined Disorder ADReCS
Impaired Gastric Emptying MetaADEDB
Impaired Healing MetaADEDB
Impetigo MetaADEDB
Incisional Drainage MetaADEDB
Incontinence ADReCS
Incorrect Route Of Drug Administration MetaADEDB
Increased Platelet Count MetaADEDB
Induration MetaADEDB
Infection ADReCS
Infection Urinary Tract MetaADEDB
Infestation SIDER
Infestation Nos SIDER
Influenza ADReCS
Influenza Like Illness MetaADEDB
Initial Insomnia MetaADEDB
Injection Site Erythema MetaADEDB
Injection Site Pruritus MetaADEDB
Injury Of Neck MetaADEDB
Insomnia ADReCS
Intention Tremor MetaADEDB
Intermittent Claudication MetaADEDB
International Normalised Ratio Increased MetaADEDB
Intervertebral Disc Herniation MetaADEDB
Intestinal Functional Disorder ADReCS
Intra-Uterine Contraceptive Device Insertion MetaADEDB
Intracranial Hypotension MetaADEDB
Ischaemic Cerebral Infarction MetaADEDB
Itch MetaADEDB
Jaw Fracture MetaADEDB
Jaw Operation MetaADEDB
Joint Effusion MetaADEDB
Joint Sprain MetaADEDB
Joint Swelling ADReCS
Kidney Failure MetaADEDB
Large Intestinal Ulcer MetaADEDB
Lethargy ADReCS
Leucopenia MetaADEDB
Light Sensitivity MetaADEDB
Liver Disorder ADReCS
Liver Operation MetaADEDB
Liver Scan Abnormal MetaADEDB
Loose Tooth MetaADEDB
Loss Of Consciousness ADReCS
Loss Of Weight MetaADEDB
Lumbar Spinal Stenosis MetaADEDB
Lymphocyte Count Decreased MetaADEDB
Lymphoma ADReCS
Macular Oedema MetaADEDB
Malaise ADReCS
Malnourished MetaADEDB
Mania MetaADEDB
Mediastinal Disorder SIDER
Medication Residue MetaADEDB
Melanocytic Naevus MetaADEDB
Menopausal Symptoms ADReCS
Menstrual Disorder MetaADEDB
Mental Disorder SIDER
Metabolic Encephalopathy MetaADEDB
Metastases To Adrenals MetaADEDB
Metastases To Liver MetaADEDB
Metastases To Lung MetaADEDB
Metastases To Lymph Nodes MetaADEDB
Metastatic Pain MetaADEDB
Mitral Valve Prolapse MetaADEDB
Mitral Valve Repair MetaADEDB
Mouth Injury MetaADEDB
Mouth Pain MetaADEDB
Mucosal Inflammation MetaADEDB
Multifocal Leukoencephalopathy MetaADEDB
Multiple Injuries MetaADEDB
Multiple Myeloma MetaADEDB
Multiple Sclerosis MetaADEDB
Multiple Sclerosis Relapse MetaADEDB
Muscle Inflammation MetaADEDB
Muscle Rigidity ADReCS
Muscle Spasms ADReCS
Muscle Weakness MetaADEDB
Musculoskeletal Chest Pain MetaADEDB
Musculoskeletal Discomfort ADReCS
Musculoskeletal Disorder MetaADEDB
Myalgia ADReCS
Myelopathy MetaADEDB
Nail Tinea MetaADEDB
Nasal Disorder MetaADEDB
Nasal Septal Operation MetaADEDB
Nasal Septum Disorder MetaADEDB
Nasopharyngitis ADReCS
Nausea ADReCS
Neck Mass MetaADEDB
Neoplasm ADReCS
Neoplasm Malignant ADReCS
Nephrolithiasis MetaADEDB
Nervous System Disorder SIDER
Nervousness ADReCS
Neumonia MetaADEDB
Nitrite Urine MetaADEDB
Nodule On Extremity MetaADEDB
Nuclear Magnetic Resonance Imaging Abnormal MetaADEDB
Obstruction Gastric MetaADEDB
Obstructive Uropathy MetaADEDB
Oedema ADReCS
Oedema Peripheral ADReCS
Oesophageal Cancer Metastatic MetaADEDB
Oesophageal Mucosal Hyperplasia MetaADEDB
Oophorectomy MetaADEDB
Oophorectomy Bilateral MetaADEDB
Optic Neuritis MetaADEDB
Oral Cavity Fistula MetaADEDB
Oral Discharge MetaADEDB
Oral Herpes MetaADEDB
Oral Infection MetaADEDB
Oral Mucosa Atrophy MetaADEDB
Oral Surgery MetaADEDB
Oropharyngeal Pain ADReCS
Oscillopsia MetaADEDB
Osteolysis MetaADEDB
Osteomyelitis MetaADEDB
Osteopenia MetaADEDB
Osteoporosis MetaADEDB
Osteosclerosis MetaADEDB
Overdose MetaADEDB
Pain ADReCS
Pain In Extremity ADReCS
Pain In Throat MetaADEDB
Painful Respiration ADReCS
Pallor ADReCS
Palmar-Plantar Erythrodysaesthesia Syndrome MetaADEDB
Palpitation MetaADEDB
Palpitations ADReCS
Palsies MetaADEDB
Paracentesis MetaADEDB
Paraesthesia ADReCS
Paraesthesia Oral MetaADEDB
Paraplegia MetaADEDB
Parathyroid Tumour Benign MetaADEDB
Parathyroidectomy MetaADEDB
Pelvic Peritoneal Adhesions MetaADEDB
Penile Prosthesis Insertion MetaADEDB
Periodontal Disease MetaADEDB
Perivascular Dermatitis MetaADEDB
Pharyngolaryngeal Pain SIDER
Plasmacytosis MetaADEDB
Pollakiuria ADReCS
Polycystic Ovaries MetaADEDB
Polyuria MetaADEDB
Post Procedural Complication MetaADEDB
Post Procedural Haemorrhage MetaADEDB
Post Thrombotic Syndrome MetaADEDB
Postmenopausal Bleeding MetaADEDB
Pregnancy SIDER
Pregnancy On Oral Contraceptive MetaADEDB
Presyncope ADReCS
Primary Sequestrum MetaADEDB
Procedural Complication MetaADEDB
Prostate Cancer Recurrent MetaADEDB
Protein Total Decreased MetaADEDB
Pseudomonas Infection MetaADEDB
Pupil Fixed MetaADEDB
Purulent Discharge MetaADEDB
Radiotherapy MetaADEDB
Rash ADReCS
Rebound Effect ADReCS
Rectal Haemorrhage ADReCS
Regurgitation MetaADEDB
Renal Cancer MetaADEDB
Renal Impairment ADReCS
Respiratory Disorder MetaADEDB
Respiratory Failure MetaADEDB
Respiratory Tract Infection ADReCS
Retching ADReCS
Retinal Bleeding MetaADEDB
Retinal Ischaemia MetaADEDB
Retinal Vascular Occlusion MetaADEDB
Retroperitoneal Lymphadenopathy MetaADEDB
Rhinorrhea MetaADEDB
Rhonchi MetaADEDB
Rib Fracture MetaADEDB
Rigors SIDER
Risus Sardonicus MetaADEDB
Road Traffic Accident MetaADEDB
Salivary Duct Obstruction MetaADEDB
Shock ADReCS
Sinusitis ADReCS
Skin Fibrosis MetaADEDB
Skin Irritation ADReCS
Skin Neoplasm Excision MetaADEDB
Sleep Apnea MetaADEDB
Small Intestinal Obstruction MetaADEDB
Social Problem MetaADEDB
Spinal Column Stenosis MetaADEDB
Spinal Deformity MetaADEDB
Spinal Osteoarthritis MetaADEDB
Spinning Sensation MetaADEDB
Staring MetaADEDB
Stem Cell Transplant MetaADEDB
Stomach Discomfort ADReCS
Stress Fracture MetaADEDB
Sweating SIDER
Swelling ADReCS
Syncope ADReCS
Syncope Vasovagal ADReCS
Tachycardia ADReCS
Temperature Intolerance MetaADEDB
Tenderness ADReCS
Tension ADReCS
Teratogenicity ADReCS
Testicular Disorder ADReCS
Therapy Regimen Changed MetaADEDB
Throat Tightness ADReCS
Thyroid Cancer MetaADEDB
Thyroid Cyst MetaADEDB
Thyroid Neoplasia MetaADEDB
Thyroidectomy MetaADEDB
Tooth Disease MetaADEDB
Tooth Extraction MetaADEDB
Tooth Fracture MetaADEDB
Tooth Infection MetaADEDB
Tooth Loss MetaADEDB
Tooth Repair MetaADEDB
Torsade De Pointes MetaADEDB
Tremor ADReCS
Ulcer MetaADEDB
Underdose MetaADEDB
Unevaluable Event MetaADEDB
Unresponsive To Stimuli MetaADEDB
Upper Respiratory Tract Infection ADReCS
Upset Stomach SIDER
Urethral Caruncle MetaADEDB
Urethral Papilloma MetaADEDB
Urinary Tract Infection ADReCS
Urticaria ADReCS
Vertigo ADReCS
Viith Nerve Paralysis MetaADEDB
Viral Diarrhoea ADReCS
Viral Infection ADReCS
Volvulus MetaADEDB
Vomiting ADReCS
Weight Increased ADReCS
Wheeze MetaADEDB
Wound Dehiscence MetaADEDB
Wound Drainage MetaADEDB

InAADR: Drug-Protein-ADRs database