InAADR

Drug Information

Drug Name: Lomustine (13010-47-4)
PubChem ID: 3950
SMILES: C1CCC(CC1)NC(=O)N(CCCl)N=O
InchiKey: GQYIWUVLTXOXAJ-UHFFFAOYSA-N
Therapeutic Category: Alkylating Agents, Antineoplastic Agents, Noxae

Computed Drug Properties

Molecular Weight (dalton): 233.699
LogP: 2.2509
Ring Count: 0
Hydrogen Bond Acceptor Count: 3
Hydrogen Bond Donor Count: 1
Total Polar Surface Area: 61.77

This panel provides information on interacting drugs and their ADRs along with references

Interacting drug Toxicity Interaction Type Mechanism Reference
Theophylline (58-55-9) Thrombocytopenia Synergistic theophylline inhibited the activity of phosphodiesterase within the platelets, thereby increasing cyclic AMP levels and disrupting normal platelet function, while lomustine causes thrombocytopenia. Theophylline-induced lomustine toxicity

This panel provides drug-protein interaction and their ADRs along with references

Toxicity Interacting Protein Mechanism Reference

This panel provides drug-food interactions and their ADRs along with references

Food Toxicity Reference

This panel provides information on metabolites and their ADRs along with references

Metabolite Toxicity Place of Metabolism Mechanism Reference

This panel provides information on drug category

Toxicity Source
Acute Leukaemia ADReCS
Alopecia ADReCS
Anaemia ADReCS
Anemia MetaADEDB
Anemia Aplastic MetaADEDB
Astrocytoma MetaADEDB
Ataxia ADReCS
Atrophy ADReCS
Azotaemia ADReCS
Blindness ADReCS
Blood Alkaline Phosphatase Increased ADReCS
Blood Bilirubin Increased ADReCS
Bone Marrow Diseases MetaADEDB
Bone Marrow Failure ADReCS
Brain Diseases MetaADEDB
Brain Edema MetaADEDB
Brain Neoplasms MetaADEDB
Carcinoma Bronchogenic MetaADEDB
Central Nervous System Neoplasms MetaADEDB
Cerebral Hemorrhage MetaADEDB
Cholestasis MetaADEDB
Death ADReCS
Depressive Disorder MetaADEDB
Disorientation ADReCS
Drug Toxicity MetaADEDB
Drug-Induced Liver Injury MetaADEDB
Dysarthria ADReCS
Dysplasia ADReCS
Eye Neoplasms MetaADEDB
Fasting ADReCS
Fatigue MetaADEDB
Fibrosis ADReCS
Gastrointestinal Diseases MetaADEDB
Gastrointestinal Toxicity ADReCS
Glioblastoma MetaADEDB
Glioma MetaADEDB
Hearing Loss MetaADEDB
Heart Diseases MetaADEDB
Heart Failure MetaADEDB
Hematoma Subdural MetaADEDB
Histiocytic Disorders Malignant MetaADEDB
Hodgkin Disease MetaADEDB
Hyperplasia MetaADEDB
Kidney Diseases MetaADEDB
Kidney Failure Chronic MetaADEDB
Kidney Small ADReCS
Lethargy ADReCS
Leukaemia ADReCS
Leukopenia ADReCS
Liver Failure MetaADEDB
Lung Infiltration ADReCS
Lung Neoplasms MetaADEDB
Lymphoma MetaADEDB
Melanoma MetaADEDB
Myelodysplastic Syndrome ADReCS
Myelosuppression SIDER
Myocardial Infarction MetaADEDB
Nausea ADReCS
Neoplasms MetaADEDB
Neoplasms Experimental MetaADEDB
Neoplasms Neuroepithelial MetaADEDB
Nephritis Interstitial MetaADEDB
Neutropenia MetaADEDB
Oligodendroglioma MetaADEDB
Optic Atrophy ADReCS
Osteoarthritis ADReCS
Overdose MetaADEDB
Pancreatic Neoplasms MetaADEDB
Pancytopenia ADReCS
Pulmonary Fibrosis ADReCS
Pulmonary Toxicity ADReCS
Renal Failure ADReCS
Renal Injury ADReCS
Renal Insufficiency MetaADEDB
Sarcoma Experimental MetaADEDB
Small Cell Lung Carcinoma MetaADEDB
Stomatitis ADReCS
Thrombocytopenia ADReCS
Transaminases Increased ADReCS
Vipoma MetaADEDB
Visual Disturbance ADReCS
Visual Impairment ADReCS
Vomiting ADReCS

InAADR: Drug-Protein-ADRs database