InAADR

Drug Information

Drug Name: Flunitrazepam (1622-62-4)
PubChem ID: 3380
SMILES: CN1C(=O)CN=C(C2=C1C=CC(=C2)[N+](=O)[O-])C3=CC=CC=C3F
InchiKey: PPTYJKAXVCCBDU-UHFFFAOYSA-N
Therapeutic Category: Anti-Anxiety Agents, Central Nervous System Agents, Central Nervous System Depressants, GABA Agents, GABA Modulators, Neurotransmitter Agents, Psychotropic Drugs, Tranquilizing Agents

Computed Drug Properties

Molecular Weight (dalton): 313.288
LogP: 2.5477
Ring Count: 2
Hydrogen Bond Acceptor Count: 4
Hydrogen Bond Donor Count: 0
Total Polar Surface Area: 75.81

This panel provides information on interacting drugs and their ADRs along with references

Interacting drug Toxicity Interaction Type Mechanism Reference

This panel provides drug-protein interaction and their ADRs along with references

Toxicity Interacting Protein Mechanism Reference

This panel provides drug-food interactions and their ADRs along with references

Food Toxicity Reference

This panel provides information on metabolites and their ADRs along with references

Metabolite Toxicity Place of Metabolism Mechanism Reference

This panel provides information on drug category

Toxicity Source
Abdominal Compartment Syndrome MetaADEDB
Abdominal Pain MetaADEDB
Abdominal Symptom MetaADEDB
Abnormal Eeg MetaADEDB
Abnormal Gait MetaADEDB
Abnormal Movements MetaADEDB
Abortion MetaADEDB
Abulia MetaADEDB
Abuse MetaADEDB
Accident MetaADEDB
Activation Syndrome MetaADEDB
Acute Brain Syndrome MetaADEDB
Acute Kidney Failure MetaADEDB
Acute Respiratory Distress Syndrome MetaADEDB
Acute Respiratory Failure MetaADEDB
Adenopathy MetaADEDB
Adh Inappropriate MetaADEDB
Adrenal Carcinoma MetaADEDB
Adynamic Ileus MetaADEDB
Aggression MetaADEDB
Agitated MetaADEDB
Agranulocytoses MetaADEDB
Alanine Aminotransferase Increased MetaADEDB
Alcohol Poisoning MetaADEDB
Alcoholic Intoxication MetaADEDB
Alcoholic Liver Disease MetaADEDB
Alcoholism MetaADEDB
Altered State Of Consciousness MetaADEDB
Alveolitis MetaADEDB
Amenorrhea MetaADEDB
Amnesia MetaADEDB
Amnesia Anterograde MetaADEDB
Anaemia MetaADEDB
Anaesthesia MetaADEDB
Analgesic Drug Level Increased MetaADEDB
Anhidrosis MetaADEDB
Anorexia MetaADEDB
Anosmia MetaADEDB
Anoxia MetaADEDB
Anticholinergic Syndrome MetaADEDB
Antidepressant Drug Clearance Decreased MetaADEDB
Antidiuretic Hormone Abnormality MetaADEDB
Anuria MetaADEDB
Anxiety MetaADEDB
Apathy MetaADEDB
Aphthous Stomatitis MetaADEDB
Apnea MetaADEDB
Arrhythmia MetaADEDB
Arterial Occlusive Diseases MetaADEDB
Arterial Pressure Nos Decreased MetaADEDB
Ascites MetaADEDB
Aspartate Aminotransferase Increase MetaADEDB
Asphyxia MetaADEDB
Aspiration Pneumonia MetaADEDB
Attempted Suicide MetaADEDB
Atypical Mycobacterial Infection MetaADEDB
Aura MetaADEDB
Automatism MetaADEDB
Autonomic Instability MetaADEDB
Behcet Syndrome MetaADEDB
Beta 2 Microglobulin Increased MetaADEDB
Biliary Anastomosis MetaADEDB
Biliary Fibrosis MetaADEDB
Biloma MetaADEDB
Bipolar Disorder MetaADEDB
Bipolar I Disorder MetaADEDB
Birth Trauma MetaADEDB
Bladder Retention MetaADEDB
Blepharoptosis MetaADEDB
Blood Albumin Decreased MetaADEDB
Blood Alkaline Phosphatase Increased MetaADEDB
Blood Beta-D-Glucan Increased MetaADEDB
Blood Chloride Abnormal MetaADEDB
Blood Chloride Decreased MetaADEDB
Blood Chloride Increased MetaADEDB
Blood Cholesterol Decreased MetaADEDB
Blood Cholinesterase Decreased MetaADEDB
Blood Cortisol Increased MetaADEDB
Blood Creatine Increased MetaADEDB
Blood Creatine Phosphokinase Increased MetaADEDB
Blood Creatine Phosphokinase Mb Increased MetaADEDB
Blood Glucose Abnormal MetaADEDB
Blood Glucose Fluctuation MetaADEDB
Blood In Urine MetaADEDB
Blood Lactate Dehydrogenase MetaADEDB
Blood Lactate Dehydrogenase Increased MetaADEDB
Blood Magnesium Increased MetaADEDB
Blood Parathyroid Hormone Increased MetaADEDB
Blood Phosphorus Decreased MetaADEDB
Blood Potassium MetaADEDB
Blood Potassium Decreased MetaADEDB
Blood Potassium Increased MetaADEDB
Blood Pressure Immeasurable MetaADEDB
Blood Pressure Systolic Decreased MetaADEDB
Blood Prolactin Increased MetaADEDB
Blood Sodium MetaADEDB
Blood Sodium Increased MetaADEDB
Blood Triglycerides Decreased MetaADEDB
Blood Urea Decreased MetaADEDB
Blunted Affect MetaADEDB
Body Temperature MetaADEDB
Body Temperature Increased MetaADEDB
Bone Marrow Failure MetaADEDB
Bradypnoea MetaADEDB
Brain Stem Haemorrhage MetaADEDB
Breast Pain MetaADEDB
Bronchoalveolar Lavage MetaADEDB
Bruxism MetaADEDB
Bulbar Palsy MetaADEDB
C-Reactive Protein Abnormal MetaADEDB
C-Reactive Protein Increased MetaADEDB
Caesarean Section MetaADEDB
Calculus Urinary MetaADEDB
Carbohydrate Antigen 19-9 MetaADEDB
Carcinoid Syndrome MetaADEDB
Carcinoma Of The Colon MetaADEDB
Cardiac Death MetaADEDB
Cardiac Failure MetaADEDB
Cardiac Failure Acute MetaADEDB
Cardiac Function Test Abnormal MetaADEDB
Cardiac Hypertrophy MetaADEDB
Cardiac Perforation MetaADEDB
Cardio-Respiratory Arrest MetaADEDB
Cardiogenic Shock MetaADEDB
Cardiomyopathy MetaADEDB
Cardiotoxicity MetaADEDB
Cardiovascular Insufficiency MetaADEDB
Cardioversion MetaADEDB
Cataplexy MetaADEDB
Catatonia MetaADEDB
Catheterisation Cardiac MetaADEDB
Central Nervous System Lesion MetaADEDB
Cerebellar Infarction MetaADEDB
Cerebral Artery Occlusion MetaADEDB
Cerebral Infarct MetaADEDB
Chemotherapeutic Drug Level Increased MetaADEDB
Chloroma MetaADEDB
Choking MetaADEDB
Chronic Fatigue Syndrome MetaADEDB
Citrobacter Infection MetaADEDB
Cogwheel Rigidity MetaADEDB
Colpitis MetaADEDB
Coma MetaADEDB
Communication Disorder MetaADEDB
Completed Suicide MetaADEDB
Computerised Tomogram Thorax Abnormal MetaADEDB
Condition Aggravated MetaADEDB
Confusion MetaADEDB
Conjunctival Deposit MetaADEDB
Conjunctival Hyperaemia MetaADEDB
Consciousness Fluctuating MetaADEDB
Constipated MetaADEDB
Contracted Bladder MetaADEDB
Convulsions Grand Mal MetaADEDB
Corneal Erosion MetaADEDB
Crying MetaADEDB
Csf Lymphocyte Count Increased MetaADEDB
Csf Protein MetaADEDB
Cutaneous Ulcer MetaADEDB
Deafness Neurosensory MetaADEDB
Decreased Activity MetaADEDB
Delusion MetaADEDB
Dementia Alzheimer Type MetaADEDB
Depressed Level Of Consciousness MetaADEDB
Depressed Mood MetaADEDB
Depressive Disorder MetaADEDB
Depressive Disorder Major MetaADEDB
Depressive Symptom MetaADEDB
Dermatitis Medicamentosa MetaADEDB
Dermatitis Seborrheic MetaADEDB
Detached Retina MetaADEDB
Diabetes Insipidus MetaADEDB
Dialysis MetaADEDB
Diaphragmalgia MetaADEDB
Diet Refusal MetaADEDB
Diplopia MetaADEDB
Disease Of Liver MetaADEDB
Disinhibition MetaADEDB
Disorders Of Excessive Somnolence MetaADEDB
Disseminated Intravascular Coagulation MetaADEDB
Dissociative Fugue MetaADEDB
Disuse Syndrome MetaADEDB
Dizziness MetaADEDB
Drowsiness MetaADEDB
Drug Abuser MetaADEDB
Drug Administered At Inappropriate Site MetaADEDB
Drug Diversion MetaADEDB
Drug Exposure Via Breast Milk MetaADEDB
Drug Interaction MetaADEDB
Drug Toxicity MetaADEDB
Drug Withdrawal MetaADEDB
Drug Withdrawal Syndrome Neonatal MetaADEDB
Dysgraphia MetaADEDB
Dyslalia MetaADEDB
Dyspnea MetaADEDB
Dyspnea Exertional MetaADEDB
Dyspnoea Exacerbated MetaADEDB
Dysthymic Disorder MetaADEDB
Dysuria MetaADEDB
Ear Pruritus MetaADEDB
Early Morning Awakening MetaADEDB
Eating Disorder MetaADEDB
Echocardiogram Abnormal MetaADEDB
Electrocardiogram Qt Corrected Interval Prolonged MetaADEDB
Elevated Mood MetaADEDB
Embolism Pulmonary MetaADEDB
Empyema MetaADEDB
Encephalitis MetaADEDB
Encephalitis Allergic MetaADEDB
Encephalopathy MetaADEDB
Enteritis Infectious MetaADEDB
Enterococcal Infection MetaADEDB
Enterocolitis MetaADEDB
Enterocolitis Bacterial MetaADEDB
Enterocolitis Infectious MetaADEDB
Eosinophil Percentage Decreased MetaADEDB
Erectile Dysfunction MetaADEDB
Erosive Oesophagitis MetaADEDB
Erythema Annulare MetaADEDB
Erythema Multiforme MetaADEDB
Erythropenia MetaADEDB
Esophageal Stenosis MetaADEDB
Euphoric Mood MetaADEDB
Excessive Salivation MetaADEDB
Excessive Thirst MetaADEDB
Extensor Plantar Response MetaADEDB
Extrapyramidal Disorder MetaADEDB
Extrasystoles Ventricular MetaADEDB
Eyelid Function Disorder MetaADEDB
Eyelids Pruritus MetaADEDB
Facial Palsy MetaADEDB
Facial Spasm MetaADEDB
Faecal Incontinence MetaADEDB
Faecal Volume Increased MetaADEDB
Faecaloma MetaADEDB
Family Stress MetaADEDB
Feeding Disorder Neonatal MetaADEDB
Feeling Of Relaxation MetaADEDB
Fluid Intake Reduced MetaADEDB
Food Allergy MetaADEDB
Galactorrhea MetaADEDB
Gamma-Glutamyltransferase Increased MetaADEDB
Gastric Cancer MetaADEDB
Gastric Ulcer Haemorrhage MetaADEDB
Gastroduodenitis MetaADEDB
Gastrointestinal Hypomotility MetaADEDB
Glomerulosclerosis MetaADEDB
Glossoptosis MetaADEDB
Graft Infection MetaADEDB
Granulocyte Count Decreased MetaADEDB
Grip Strength MetaADEDB
Haemodialysis MetaADEDB
Haemorrhage Subcutaneous MetaADEDB
Haemorrhagic Cerebral Infarction MetaADEDB
Head Titubation MetaADEDB
Heart Arrest MetaADEDB
Heart Rate Increased MetaADEDB
Hepatic Function Abnormal MetaADEDB
Hepatitis Acute MetaADEDB
Hiccough MetaADEDB
High Density Lipoprotein Increased MetaADEDB
Hiv Positive MetaADEDB
Hordeolum MetaADEDB
Hostility MetaADEDB
Hyperaesthesia MetaADEDB
Hyperalimentation MetaADEDB
Hyperammonaemia MetaADEDB
Hyperhidrosis MetaADEDB
Hyperkinesis MetaADEDB
Hyperprolactinaemia MetaADEDB
Hypertension MetaADEDB
Hypertonia MetaADEDB
Hypertonia Neonatal MetaADEDB
Hyperventilation MetaADEDB
Hypoaesthesia MetaADEDB
Hypoalbuminaemia MetaADEDB
Hypoglycaemia Neonatal MetaADEDB
Hypomania MetaADEDB
Hypophagia MetaADEDB
Hypoproteinaemia MetaADEDB
Hyporeflexia MetaADEDB
Hypothyroid MetaADEDB
Hypotonia MetaADEDB
Hypotonia Neonatal MetaADEDB
Hypoxic Encephalopathy MetaADEDB
Ild MetaADEDB
Ileal Ulcer MetaADEDB
Impulse-Control Disorder MetaADEDB
Impulsive Behaviour MetaADEDB
Inadequate Diet MetaADEDB
Incoherent MetaADEDB
Incontinence MetaADEDB
Increased White Blood Cell Count MetaADEDB
Infected Epidermal Cyst MetaADEDB
Infection In An Immunocompromised Host MetaADEDB
Infection Susceptibility Increased MetaADEDB
Infection Viral MetaADEDB
Injection Site Nodule MetaADEDB
Injury Asphyxiation MetaADEDB
Intention Tremor MetaADEDB
Intentional Drug Misuse MetaADEDB
Intentional Misuse MetaADEDB
Intentional Self-Injury MetaADEDB
Intervertebral Discitis MetaADEDB
Intestinal Hypomotility MetaADEDB
Intracranial Tumour Haemorrhage MetaADEDB
Intranasal Paraesthesia MetaADEDB
Intubation MetaADEDB
Ischemia MetaADEDB
Japan Coma Scale Abnormal MetaADEDB
Jejunal Perforation MetaADEDB
Jejunitis MetaADEDB
Kidney Diseases MetaADEDB
Klebsiella Infection MetaADEDB
Laboratory Test Interference MetaADEDB
Leucopenia MetaADEDB
Leukoencephalopathy MetaADEDB
Leukopenia Neonatal MetaADEDB
Life Support MetaADEDB
Lip Ulceration MetaADEDB
Locked-In Syndrome MetaADEDB
Logorrhoea MetaADEDB
Lung Neoplasm Malignant MetaADEDB
Lymphocyte Percentage Decreased MetaADEDB
Lymphocyte Stimulation Test Positive MetaADEDB
Macrocytosis MetaADEDB
Major Depression MetaADEDB
Malignant Neoplasm Progression MetaADEDB
Mallory-Weiss Syndrome MetaADEDB
Meconium Stain MetaADEDB
Megacolon MetaADEDB
Meige Syndrome MetaADEDB
Melaena Neonatal MetaADEDB
Meningitides MetaADEDB
Menstrual Disorder MetaADEDB
Metabolic Acidosis MetaADEDB
Metamyelocyte Count Increased MetaADEDB
Metastases To Central Nervous System MetaADEDB
Miosis MetaADEDB
Monoplegia MetaADEDB
Mood Altered MetaADEDB
Morphea MetaADEDB
Motor Skills Disorders MetaADEDB
Mouth Breathing MetaADEDB
Multiple Drug Overdose MetaADEDB
Multiple Drug Overdose Intentional MetaADEDB
Multiple Sclerosis Relapse MetaADEDB
Murder MetaADEDB
Muscle Necrosis MetaADEDB
Muscle Tightness MetaADEDB
Musculoskeletal Stiffness MetaADEDB
Myelocyte Count Increased MetaADEDB
Myofascitis MetaADEDB
Myoglobin Blood Increased MetaADEDB
Myoglobin Urine Present MetaADEDB
Nasopharyngitis MetaADEDB
Neonatal Asphyxia MetaADEDB
Neoplasia MetaADEDB
Neumonia MetaADEDB
Neurogenic Bladder MetaADEDB
Neuroleptic Malignant Syndrome MetaADEDB
Neurosis MetaADEDB
Neutrophilia MetaADEDB
Nikolsky Sign MetaADEDB
Nuclear Magnetic Resonance Imaging Abnormal MetaADEDB
Nystagmus MetaADEDB
Oculomucocutaneous Syndrome MetaADEDB
Open Wound MetaADEDB
Oral Herpes MetaADEDB
Oral Intake Reduced MetaADEDB
Oropharyngeal Pain MetaADEDB
Orthopnea MetaADEDB
Ovarian Cancer MetaADEDB
Overdose MetaADEDB
Pain MetaADEDB
Palsies MetaADEDB
Parapsoriasis MetaADEDB
Parkinson MetaADEDB
Parkinsonian Gait MetaADEDB
Paronychia MetaADEDB
Paroxysmal Perceptual Alteration MetaADEDB
Partner Stress MetaADEDB
Patient Restraint MetaADEDB
Pedal Pulse Absent MetaADEDB
Periarthritis MetaADEDB
Pericardial Haemorrhage MetaADEDB
Persecutory Delusion MetaADEDB
Persistent Foetal Circulation MetaADEDB
Personality Change MetaADEDB
Pharyngeal Erythema MetaADEDB
Pharyngotonsillitis MetaADEDB
Phlebitis MetaADEDB
Phobia MetaADEDB
Photosensitive Rash MetaADEDB
Physical Assault MetaADEDB
Piloerection MetaADEDB
Pleural Effusion MetaADEDB
Pleurisy MetaADEDB
Pms MetaADEDB
Pneumocystis Jiroveci Pneumonia MetaADEDB
Pneumonia Staphylococcal MetaADEDB
Pollakiuria MetaADEDB
Poriomania MetaADEDB
Post Procedural Bile Leak MetaADEDB
Postoperative Complications MetaADEDB
Protein Total Decreased MetaADEDB
Psychiatric Symptom MetaADEDB
Psychomotor Agitation MetaADEDB
Psychomotor Skills Impaired MetaADEDB
Psychotic Disorders MetaADEDB
Pulmonary Arrest MetaADEDB
Pulmonary Infarction MetaADEDB
Pyelonephritis Acute MetaADEDB
Red Blood Cell Count Increased MetaADEDB
Reflux Esophagitis MetaADEDB
Renal Atrophy MetaADEDB
Renin Increased MetaADEDB
Respiratory Disorder MetaADEDB
Respiratory Disorder Neonatal MetaADEDB
Respiratory Failure MetaADEDB
Respiratory Rate Increased MetaADEDB
Retinal Vasculitis MetaADEDB
Retrocollis MetaADEDB
Reye Syndrome MetaADEDB
Rhabdomyolysis MetaADEDB
Rhinitis MetaADEDB
Schizophrenia MetaADEDB
Seizures MetaADEDB
Self Injurious Behaviour MetaADEDB
Self-Injurious Ideation MetaADEDB
Sensory Disturbance MetaADEDB
Sepsis Syndrome MetaADEDB
Sexual Abuse MetaADEDB
Sexual Offence MetaADEDB
Silent Myocardial Infarction MetaADEDB
Skin Laceration MetaADEDB
Skin Lesion MetaADEDB
Sleep Disorder MetaADEDB
Sleep Disorders MetaADEDB
Sleep Initiation And Maintenance Disorders MetaADEDB
Sleep Phase Rhythm Disturbance MetaADEDB
Sleep-Related Eating Disorder MetaADEDB
Soliloquy MetaADEDB
Somatisation Disorder MetaADEDB
Somatoform Disorder MetaADEDB
Speech Disorder MetaADEDB
Sputum Retention MetaADEDB
Status Epilepticus MetaADEDB
Stevens-Johnson Syndrome MetaADEDB
Subileus MetaADEDB
Substance Abuse MetaADEDB
Substance Withdrawal Syndrome MetaADEDB
Sudden Death MetaADEDB
Tachycardia MetaADEDB
Tachycardia Ventricular MetaADEDB
Tarsal Tunnel Syndrome MetaADEDB
Tearfulness MetaADEDB
Testes Pain MetaADEDB
Theft MetaADEDB
Thrombocytopenia MetaADEDB
Thrombophlebitis MetaADEDB
Thrombosis MetaADEDB
Tinnitus MetaADEDB
Total Lung Capacity Decreased MetaADEDB
Transmission Of Drug Via Semen MetaADEDB
Unevaluable Event MetaADEDB
Unresponsive To Verbal Stimuli MetaADEDB
Upper Gastrointestinal Bleeding MetaADEDB
Urine Colour Abnormal MetaADEDB
Urine Output Increased MetaADEDB
Vascular Stent Insertion MetaADEDB
Venous Thrombosis MetaADEDB
Venous Thrombosis Limb MetaADEDB
Vertigo Positional MetaADEDB
Vital Capacity Decreased MetaADEDB
Water Intoxication MetaADEDB
Weight Gain Poor MetaADEDB
Wheeze MetaADEDB
Zinc Sulphate Turbidity Decreased MetaADEDB

InAADR: Drug-Protein-ADRs database