| Drug Name: | Etretinate (54350-48-0) |
|---|---|
| PubChem ID: | 5282375 |
| SMILES: | CCOC(=O)/C=C(C)/C=C/C=C(C)/C=C/C1=C(C(=C(C=C1C)OC)C)C |
| InchiKey: | HQMNCQVAMBCHCO-DJRRULDNSA-N |
| Therapeutic Category: | Dermatologic Agents, Keratolytic Agents |
| Molecular Weight (dalton) | : | 354.49 |
| LogP | : | 5.64556 |
| Ring Count | : | 1 |
| Hydrogen Bond Acceptor Count | : | 3 |
| Hydrogen Bond Donor Count | : | 0 |
| Total Polar Surface Area | : | 35.53 |
This panel provides information on interacting drugs and their ADRs along with references
| Interacting drug | Toxicity | Interaction Type | Mechanism | Reference |
|---|---|---|---|---|
| Methotrexate (59-05-2) | Hepatotoxicity | Synergistic | Not understood | Methotrexate and retinoids in combination for psoriasis |
This panel provides drug-protein interaction and their ADRs along with references
| Toxicity | Interacting Protein | Mechanism | Reference |
|---|---|---|---|
| Disturb Lipoprotein Metabolism | Lipoprotein lipase precursor (P06858) | Etretinate often generates side effects which disturb lipoprotein metabolism;it appeared that the decrease of LPL activity in this case was mainly due to the administration of etretinate. [ ADR Type 1 ] | A case of psoriasis vulgaris whose lipoprotein lipase activity decreased during treatment with etretinate |
| Disturb Lipoprotein Metabolism | Peroxiredoxin (Q13162) | Etretinate often generates side effects which disturb lipoprotein metabolism;it appeared that the decrease of LPL activity in this case was mainly due to the administration of etretinate [ ADR Type 1 ] | A case of psoriasis vulgaris whose lipoprotein lipase activity decreased during treatment with etretinate |
| Hypertriglyceridemia | Retinoic acid receptor (P10276) | Retinoid-induced hypertriglyceridemia is mediated by retinoic acid receptors (RARs) and/or by retinoid X receptors (RXRs). [ ADR Type 2 ] | Retinoid-induced hypertriglyceridemia in rats is mediated by retinoic acid receptors |
| Hypertriglyceridemia | Retinoic acid receptor (P19793) | Retinoid-induced hypertriglyceridemia is mediated by retinoic acid receptors (RARs) and/or by retinoid X receptors (RXRs) [ ADR Type 2 ] | Retinoid-induced hypertriglyceridemia in rats is mediated by retinoic acid receptors |
This panel provides drug-food interactions and their ADRs along with references
| Food | Toxicity | Reference |
|---|
This panel provides information on metabolites and their ADRs along with references
| Metabolite | Toxicity | Place of Metabolism | Mechanism | Reference |
|---|
This panel provides information on drug category