InAADR

Drug Information

Drug Name: Estramustine (2998-57-4)
PubChem ID: 259331
SMILES: C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2O)CCC4=C3C=CC(=C4)OC(=O)N(CCCl)CCCl
InchiKey: FRPJXPJMRWBBIH-RBRWEJTLSA-N
Therapeutic Category: Alkylating Agents, Antineoplastic Agents, Noxae

Computed Drug Properties

Molecular Weight (dalton): 440.411
LogP: 5.182
Ring Count: 1
Hydrogen Bond Acceptor Count: 3
Hydrogen Bond Donor Count: 1
Total Polar Surface Area: 49.77

This panel provides information on interacting drugs and their ADRs along with references

Interacting drug Toxicity Interaction Type Mechanism Reference

This panel provides drug-protein interaction and their ADRs along with references

Toxicity Interacting Protein Mechanism Reference

This panel provides drug-food interactions and their ADRs along with references

Food Toxicity Reference

This panel provides information on metabolites and their ADRs along with references

Metabolite Toxicity Place of Metabolism Mechanism Reference

This panel provides information on drug category

Toxicity Source
Abdominal Discomfort ADReCS
Abdominal Hernia MetaADEDB
Abdominal Infection MetaADEDB
Abdominal Pain MetaADEDB
Abdominal Pain MetaADEDB
Abnormal Movements MetaADEDB
Abscess MetaADEDB
Accelerated Hypertension MetaADEDB
Acute Coronary Syndrome ADReCS
Acute Kidney Failure MetaADEDB
Acute Myeloblastic Leukemia MetaADEDB
Acute Respiratory Failure MetaADEDB
Adenopathy MetaADEDB
Adrenal Insufficiency MetaADEDB
Affect Lability ADReCS
Afib MetaADEDB
Agraphia MetaADEDB
Alanine Aminotransferase MetaADEDB
Allergic Rhinitis MetaADEDB
Alopecia ADReCS
Amnesia MetaADEDB
Anaemia ADReCS
Anaesthesia MetaADEDB
Anemia MetaADEDB
Angioedema ADReCS
Anhedonia MetaADEDB
Anorexia ADReCS
Anxiety ADReCS
Aortic Arteriosclerosis MetaADEDB
Aphthous Stomatitis MetaADEDB
Apoplexy MetaADEDB
Arterial Haemorrhage MetaADEDB
Arterial Pressure Nos Decreased MetaADEDB
Aseptic Necrosis Bone MetaADEDB
Aspartate Aminotransferase Abnormal ADReCS
Asthenia ADReCS
Back Ache MetaADEDB
Balance Disorder ADReCS
Belching MetaADEDB
Benign Neoplasm Of Bladder MetaADEDB
Beta Haemolytic Streptococcal Infection MetaADEDB
Bile Duct Stone MetaADEDB
Biopsy Site Unspecified Abnormal MetaADEDB
Bleeding Gums MetaADEDB
Blood Bilirubin Abnormal ADReCS
Blood Calcium MetaADEDB
Blood Chloride Decreased MetaADEDB
Blood In Urine MetaADEDB
Blood Lactate Dehydrogenase Increased ADReCS
Blood Product Transfusion MetaADEDB
Blood Sodium MetaADEDB
Body Temperature Increased MetaADEDB
Bone Debridement MetaADEDB
Bone Disorder MetaADEDB
Bone Fracture Spontaneous MetaADEDB
Bone Infection MetaADEDB
Bone Marrow Depression MetaADEDB
Bone Marrow Diseases MetaADEDB
Bone Marrow Failure MetaADEDB
Bone Operation MetaADEDB
Bone Pain MetaADEDB
Bowel Movement Irregularity MetaADEDB
Bradypnoea MetaADEDB
Brain Ischemia MetaADEDB
Brain Stem Infarction MetaADEDB
Breast Enlargement ADReCS
Bronchiectasis MetaADEDB
Bronchitis MetaADEDB
Calcinosis MetaADEDB
Calculus Ureteric MetaADEDB
Cardiac Arrest ADReCS
Cardiac Decompensation MetaADEDB
Cardiac Disorder ADReCS
Cardiac Failure ADReCS
Cardiac Failure Congestive ADReCS
Cardiac Ischemia MetaADEDB
Cardiac Murmur MetaADEDB
Cardiovascular Diseases MetaADEDB
Cartilage Development Disorder MetaADEDB
Cataract MetaADEDB
Cataract Operation MetaADEDB
Cellulitis MetaADEDB
Central obesity MetaADEDB
Central Venous Catheterisation MetaADEDB
Cerebral Atrophy MetaADEDB
Cerebral Infarct MetaADEDB
Cerebrovascular Accident ADReCS
Cervical Spinal Stenosis MetaADEDB
Cervicalgia MetaADEDB
Cervicobrachial Syndrome MetaADEDB
Chest Pain ADReCS
Chill MetaADEDB
Choking Sensation MetaADEDB
Cholecystectomies MetaADEDB
Clostridial Infection MetaADEDB
Clostridium Difficile Colitis MetaADEDB
Colitis MetaADEDB
Colon Spastic MetaADEDB
Coma MetaADEDB
Confusional State ADReCS
Constipated MetaADEDB
Contusion ADReCS
Cor Pulmonale MetaADEDB
Cough MetaADEDB
Cramp Muscle SIDER
Cramps Of Lower Extremities SIDER
Csf Protein MetaADEDB
Culture Positive MetaADEDB
Cyst MetaADEDB
Cyst Removal MetaADEDB
Dacryostenosis Acquired MetaADEDB
Death MetaADEDB
Debridement MetaADEDB
Decreased Appetite ADReCS
Decreased Interest MetaADEDB
Deglutition Disorder MetaADEDB
Demyelination MetaADEDB
Dental Abscess MetaADEDB
Dental Care MetaADEDB
Dental Caries MetaADEDB
Dental Fistula MetaADEDB
Dental Pain MetaADEDB
Dental Prosthesis Placement MetaADEDB
Depression ADReCS
Dermal Cyst MetaADEDB
Dermatitis ADReCS
Diarrhea MetaADEDB
Diarrhoea ADReCS
Disequilibrium Syndrome SIDER
Disorder Peripheral Vascular MetaADEDB
Disseminated Intravascular Coagulation MetaADEDB
Disturbance In Sexual Arousal ADReCS
Diuresis SIDER
Diverticulum MetaADEDB
Dizziness Exertional MetaADEDB
Drowsiness MetaADEDB
Drug Intolerance MetaADEDB
Drug Prescribing Error MetaADEDB
Drug Toxicity MetaADEDB
Drug-Induced Liver Injury MetaADEDB
Dry Skin ADReCS
Dysphonia ADReCS
Dyspnoea ADReCS
Dysuria MetaADEDB
Early Morning Awakening MetaADEDB
Eating Disorder MetaADEDB
Edema MetaADEDB
Edema Extremities MetaADEDB
Elevated Erythrocyte Sedimentation Rate MetaADEDB
Elevated Prostate Specific Antigen MetaADEDB
Embolism ADReCS
Embolism Pulmonary MetaADEDB
Embolism Venous ADReCS
Emotional Distress ADReCS
Emphysema MetaADEDB
Encephalomalacia MetaADEDB
Endotracheal Intubation MetaADEDB
Enterocolitis MetaADEDB
Epistaxis MetaADEDB
Erectile Dysfunction MetaADEDB
Erosive Oesophagitis MetaADEDB
Erythema Migrans MetaADEDB
Excess Potassium MetaADEDB
Eye Pain ADReCS
Eye Pruritus MetaADEDB
Faecal Occult Blood Positive MetaADEDB
Failure To Thrive MetaADEDB
Fatigue MetaADEDB
Febrile Neutropenia MetaADEDB
Feeding Tube Insertion MetaADEDB
Feeling Abnormal ADReCS
Flatulence ADReCS
Fluid Overload MetaADEDB
Fluid Retention ADReCS
Flushing ADReCS
Formication MetaADEDB
Gastrointestinal Bleed MetaADEDB
Gastrointestinal Diseases MetaADEDB
Gastrointestinal Disorder ADReCS
Gastrointestinal Haemorrhage ADReCS
Gastrointestinal Symptom Nos SIDER
Gastrointestinal Tract Irritation ADReCS
General Physical Health Deterioration MetaADEDB
Gingival Erythema MetaADEDB
Gingival Infection MetaADEDB
Gingival Oedema MetaADEDB
Gingival Pain MetaADEDB
Gliosis MetaADEDB
Gynaecomastia ADReCS
Haemangioma MetaADEDB
Haematemesis MetaADEDB
Haematoma MetaADEDB
Haemoglobin ADReCS
Haemorrhage ADReCS
Haemorrhage Rectum MetaADEDB
Haemorrhagic Hepatic Cyst MetaADEDB
Haemorrhoids MetaADEDB
Headache ADReCS
Heart Diseases MetaADEDB
Heart Failure MetaADEDB
Heat Exhaustion MetaADEDB
Hemolytic-Uremic Syndrome MetaADEDB
Hernia Hiatal MetaADEDB
Hernia Inguinal MetaADEDB
Hernia Repair MetaADEDB
Hesitancy MetaADEDB
High Blood Pressure MetaADEDB
Hoarseness SIDER
Hot Flash MetaADEDB
Hot Flush ADReCS
Hydronephrosis MetaADEDB
Hydroureter MetaADEDB
Hypercalcaemia ADReCS
Hypercalcemia MetaADEDB
Hyperhidrosis ADReCS
Hyperlipaemia MetaADEDB
Hypertension ADReCS
Hypertensive Angiopathy MetaADEDB
Hypertonia MetaADEDB
Hypertrophy ADReCS
Hypoaesthesia MetaADEDB
Hypocalcemia MetaADEDB
Hypogeusia MetaADEDB
Hypomagnesaemia MetaADEDB
Hypophagia MetaADEDB
Hypophosphataemia MetaADEDB
Hypotension MetaADEDB
Hypotonia MetaADEDB
Idiopathic Thrombocytopenic Purpura MetaADEDB
Ild MetaADEDB
Impaired Healing MetaADEDB
Increased Tendency To Bruise ADReCS
Infarction ADReCS
Infected Sebaceous Cyst MetaADEDB
Infection MetaADEDB
Infection Urinary Tract MetaADEDB
Insomnia ADReCS
International Normalised Ratio Decreased MetaADEDB
International Normalised Ratio Increased MetaADEDB
Intervertebral Disc Herniation MetaADEDB
Itch MetaADEDB
Jaw Operation MetaADEDB
Kyphosis MetaADEDB
Lacrimation SIDER
Lacrimation Increased ADReCS
Leg Cramps ADReCS
Lethargy ADReCS
Leucopenia MetaADEDB
Leukoencephalopathy MetaADEDB
Leukopenia ADReCS
Leukopenia Neonatal MetaADEDB
Libido Decreased ADReCS
Limb Injury MetaADEDB
Liposarcoma MetaADEDB
Liver Diseases MetaADEDB
Localized Exfoliation SIDER
Loose Tooth MetaADEDB
Loss Of Weight MetaADEDB
Lung Fibrosis MetaADEDB
Lung Infiltration MetaADEDB
Lung Neoplasm MetaADEDB
Lymphadenopathy Mediastinal MetaADEDB
Markedly Reduced Dietary Intake MetaADEDB
Meniscus Lesion MetaADEDB
Menopausal Symptoms ADReCS
Mental Impairment MetaADEDB
Metabolic Acidosis MetaADEDB
Metastases To Central Nervous System MetaADEDB
Metastases To Lung MetaADEDB
Micturition Urgency MetaADEDB
Mood Swings ADReCS
Mouth Pain MetaADEDB
Mucosal Inflammation MetaADEDB
Muscle Mass MetaADEDB
Muscle Spasms ADReCS
Muscle Strain MetaADEDB
Muscle Weakness MetaADEDB
Muscular Weakness ADReCS
Musculoskeletal Pain MetaADEDB
Myelodysplasia MetaADEDB
Myocardial Infarction ADReCS
Myocardial Ischaemia ADReCS
Myocardial Ischemia MetaADEDB
Nasal Odour MetaADEDB
Nasopharyngitis MetaADEDB
Nausea ADReCS
Neck Mass MetaADEDB
Nephrolithiasis MetaADEDB
Neumonia MetaADEDB
Neuropathy Peripheral MetaADEDB
Neutropenia MetaADEDB
Night Sweats ADReCS
Nutritional Condition Abnormal MetaADEDB
Obstruction Gastric MetaADEDB
Oedema ADReCS
Onycholysis MetaADEDB
Oral Cavity Fistula MetaADEDB
Oral Infection MetaADEDB
Osteoarthritis MetaADEDB
Osteopenia MetaADEDB
Osteosarcoma Metastatic MetaADEDB
Ovarian Neoplasms MetaADEDB
Pain ADReCS
Pain Pelvic MetaADEDB
Pancreatitis MetaADEDB
Paraesthesia Oral MetaADEDB
Parotid Gland Enlargement MetaADEDB
Pco2 Decreased MetaADEDB
Periodontal Disease MetaADEDB
Pharyngolaryngeal Pain MetaADEDB
Physical Disability MetaADEDB
Pigmentation Disorder ADReCS
Platelet Count MetaADEDB
Pleural Effusion MetaADEDB
Pollakiuria MetaADEDB
Polyuria ADReCS
Primary Sequestrum MetaADEDB
Proctalgia MetaADEDB
Proctitis MetaADEDB
Prostate Cancer Recurrent MetaADEDB
Prostatic Haemorrhage MetaADEDB
Prostatic Neoplasms MetaADEDB
Prothrombin Time Prolonged MetaADEDB
Pruritus ADReCS
Pulmonary Congestion MetaADEDB
Pulmonary Embolism ADReCS
Pulmonary Radiation Injury MetaADEDB
Purulent Discharge MetaADEDB
Radiotherapy MetaADEDB
Rash ADReCS
Renal Cyst MetaADEDB
Renal Tubular Acidosis MetaADEDB
Respiratory Rate Increased MetaADEDB
Rib Fracture MetaADEDB
Risus Sardonicus MetaADEDB
Septic Shock MetaADEDB
Sinus Disorder MetaADEDB
Sinusitis MetaADEDB
Skin Atrophy ADReCS
Skin Exfoliation ADReCS
Spinal Column Stenosis MetaADEDB
Spinal Cord Compression MetaADEDB
Spinal Haemangioma MetaADEDB
Spinal Osteoarthritis MetaADEDB
Spondylopathy Traumatic MetaADEDB
Supraventricular Tachycardia MetaADEDB
Sweating SIDER
Telangiectases MetaADEDB
Tenderness ADReCS
Tendinitis MetaADEDB
Thirst ADReCS
Thoracic Vertebral Fracture MetaADEDB
Throat Irritation ADReCS
Thrombocytopenia ADReCS
Thromboembolism ADReCS
Thrombophlebitis ADReCS
Thrombosis MetaADEDB
Tinnitus ADReCS
Tongue Diseases MetaADEDB
Tooth Extraction MetaADEDB
Tooth Fracture MetaADEDB
Tooth Infection MetaADEDB
Tooth Repair MetaADEDB
Transaminases Increased ADReCS
Upper Respiratory Disorder ADReCS
Urine Flow Decreased MetaADEDB
Urine Output Increased ADReCS
Venous Thromboembolism MetaADEDB
Venous Thrombosis MetaADEDB
Ventricular Fibrillation MetaADEDB
Vertebroplasty MetaADEDB
Vomiting ADReCS
Weakness SIDER
Wrong Drug Administered MetaADEDB
X-Ray MetaADEDB

InAADR: Drug-Protein-ADRs database