| Drug Name: | Epinephrine (51-43-4) |
|---|---|
| PubChem ID: | 5816 |
| SMILES: | CNC[C@@H](C1=CC(=C(C=C1)O)O)O |
| InchiKey: | UCTWMZQNUQWSLP-VIFPVBQESA-N |
| Therapeutic Category: | Adrenergic Agents, Adrenergic Agonists, Adrenergic alpha-Agonists, Adrenergic beta-Agonists, Anti-Asthmatic Agents, Autonomic Agents, Bronchodilator Agents, Cardiovascular Agents, Mydriatics, Neurotransmitter Agents, Peripheral Nervous System Agents, Respiratory System Agents, Sympathomimetics, Vasoconstrictor Agents |
| Molecular Weight (dalton) | : | 183.207 |
| LogP | : | 0.3506 |
| Ring Count | : | 1 |
| Hydrogen Bond Acceptor Count | : | 4 |
| Hydrogen Bond Donor Count | : | 4 |
| Total Polar Surface Area | : | 72.72 |
This panel provides information on interacting drugs and their ADRs along with references
| Interacting drug | Toxicity | Interaction Type | Mechanism | Reference |
|---|---|---|---|---|
| Entacapone (130929-57-6) | Heart Rate Increased | Synergistic | Tolcapone inhibit the enzyme catechol-O-methyl transferase (COMT), which is concerned with the metabolism of drugs such as adrenaline (epinephrine) | The effect of entacapone on disposition and hemodynamic effects of intravenous isoproterenol and epinephrine |
This panel provides drug-protein interaction and their ADRs along with references
| Toxicity | Interacting Protein | Mechanism | Reference |
|---|---|---|---|
| Cytotoxicity | Glutathione reductase (P00390) | Pretreatment of cells with 100 microM 1,3-bis(2-chloroethyl)-1-nitrosourea which inhibits glutathione reductase,increased the sensitivity of these cells to the epinephrine plasma,which was found to be cytotoxic when incubated with isolated heart cells. [ ADR Type 1 ] | Epinephrine-induced cytotoxicity of rat plasma Its effects on isolated cardiac myocytes Lab |
| Inflammation | Interleukin-8 (P10145) | Epinephrine-induced enhancement of IL-8 production@which may be relevant for the understanding of endogenous and therapeutic stress hormone influences on IL-8 mediated inflammation [ ADR Type 5 ] | Lipopolysaccharide-induced interleukin 8 production by human whole blood is enhanced by epinephrine and inhibited by hydrocortisone |
| Myocardial Infarction | Creatine phosphokinase MB isoenzyme (CPK-MB) (P00007) | Persistently abnormal electrocardiograms and elevated creatine phosphokinase MB isoenzyme (CPK-MB) levels suggested a myocardial infarction had occurred after racemic epinephrine administration [ ADR Type 2 ] | Pediatric myocardial infarction after racemic epinephrine administration |
| Platelet Aggregation | Alpha-2A adrenergic receptor (P08913) | Alpha 2-Adrenoceptor(epinephrine and UK 14304)-mediated platelet aggregation could represent a better marker than inhibition of adenylate cyclase to assess functional changes of the receptor in depression. [ ADR Type 1 ] | Alpha 2-adrenoceptor-mediated inhibition of platelet adenylate cyclase and induction of aggregation in major depression Effect of long-term cyclic antidepressant drug treatment |
| Suppression In Human Obesity | Leptin (P41159) | Plasma leptin levels decreased by the end of the infusion@and ob messenger ribonucleic acid levels were significantly reduced (decrease amounting to 47 +/- 5% of basal values)@which provides evidence for epinephrine-induced suppression in human obesity [ ADR Type 1 ] | Regulation of ob gene expression: evidence for epinephrine-induced suppression in human obesity |
This panel provides drug-food interactions and their ADRs along with references
| Food | Toxicity | Reference |
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This panel provides information on metabolites and their ADRs along with references
| Metabolite | Toxicity | Place of Metabolism | Mechanism | Reference |
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This panel provides information on drug category