| Drug Name: | Diclofenac (15307-86-5) |
|---|---|
| PubChem ID: | 3033 |
| SMILES: | C1=CC=C(C(=C1)CC(=O)O)NC2=C(C=CC=C2Cl)Cl |
| InchiKey: | DCOPUUMXTXDBNB-UHFFFAOYSA-N |
| Therapeutic Category: | Analgesics, Anti-Inflammatory Agents, Antirheumatic Agents, Cyclooxygenase Inhibitors, Enzyme Inhibitors, Peripheral Nervous System Agents, Sensory System Agents |
| Molecular Weight (dalton) | : | 296.153 |
| LogP | : | 4.3641 |
| Ring Count | : | 2 |
| Hydrogen Bond Acceptor Count | : | 2 |
| Hydrogen Bond Donor Count | : | 2 |
| Total Polar Surface Area | : | 49.33 |
This panel provides information on interacting drugs and their ADRs along with references
| Interacting drug | Toxicity | Interaction Type | Mechanism | Reference |
|---|---|---|---|---|
| Acetylsalicylic acid (50-78-2) | Disorder Gastrointestinal | Additive | Mechanisms behind the pharmacokinetic changes is the rates of absorption and renal clearance and competition for plasma protein binding | Upper gastrointestinal bleeding among users of NSAIDs: a population-based cohort study in Denmark |
This panel provides drug-protein interaction and their ADRs along with references
| Toxicity | Interacting Protein | Mechanism | Reference |
|---|---|---|---|
| Hepatotoxicity | Cytochrome P450 2C9 (P11712) | The biotransformation of diclofenac to M2 is P450 2C9-dependent@ whereas metabolism of the drug to M1 and M3 involves mainly P450 3A4. Although P450s 2C9 and 3A4 both catalyze the bioactivation of diclofenac@ P450 2C9 is capable of producing the benzoquinone imine intermediate at lower drug concentrations which may be more clinically relevant. [ ADR Type 2 ] | Roles of human hepatic cytochrome P450s 2C9 and 3A4 in the metabolic activation of diclofenac |
| Hepatotoxicity | Cytochrome P450 3A4 (P08684) | The biotransformation of diclofenac to M2 is P450 2C9-dependent@ whereas metabolism of the drug to M1 and M3 involves mainly P450 3A4 Although P450s 2C9 and 3A4 both catalyze the bioactivation of diclofenac@ P450 2C9 is capable of producing the benzoquinone imine intermediate at lower drug concentrations which may be more clinically relevant |
This panel provides drug-food interactions and their ADRs along with references
| Food | Toxicity | Reference |
|---|
This panel provides information on metabolites and their ADRs along with references
| Metabolite | Toxicity | Place of Metabolism | Mechanism | Reference |
|---|---|---|---|---|
| 5-hydroxydiclofenac | Hepatotoxicity | Liver | Diclofenac toxicity to hepatocytes: a role for drug metabolism in cell toxicity | |
| N!5-dihydroxydiclofenac | Hepatotoxicity | Liver | Diclofenac toxicity to hepatocytes: a role for drug metabolism in cell toxicity |
This panel provides information on drug category