InAADR

Drug Information

Drug Name: Darifenacin (133099-04-4)
PubChem ID: 444031
SMILES: C1CN(C[C@@H]1C(C2=CC=CC=C2)(C3=CC=CC=C3)C(=O)N)CCC4=CC5=C(C=C4)OCC5
InchiKey: HXGBXQDTNZMWGS-RUZDIDTESA-N
Therapeutic Category: Cholinergic Agents, Cholinergic Antagonists, Muscarinic Antagonists, Neurotransmitter Agents, Urological Agents

Computed Drug Properties

Molecular Weight (dalton): 426.56
LogP: 3.9575
Ring Count: 3
Hydrogen Bond Acceptor Count: 3
Hydrogen Bond Donor Count: 1
Total Polar Surface Area: 55.56

This panel provides information on interacting drugs and their ADRs along with references

Interacting drug Toxicity Interaction Type Mechanism Reference

This panel provides drug-protein interaction and their ADRs along with references

Toxicity Interacting Protein Mechanism Reference

This panel provides drug-food interactions and their ADRs along with references

Food Toxicity Reference
Grapefruit Juice Constipation Grapefruit-medication interactions: forbidden fruit or avoidable consequences?
Grapefruit Juice Urinary Retention Grapefruit-medication interactions: forbidden fruit or avoidable consequences?

This panel provides information on metabolites and their ADRs along with references

Metabolite Toxicity Place of Metabolism Mechanism Reference

This panel provides information on drug category

Toxicity Source
Abdominal Pain ADReCS
Abnormal Behaviour MetaADEDB
Abnormal Dreams MetaADEDB
Abnormal Vision MetaADEDB
Abuse MetaADEDB
Accidental Injury ADReCS
Accidental Overdose MetaADEDB
Aching Joints MetaADEDB
Acute Myocardial Infarction MetaADEDB
Acute Retention Of Urine SIDER
Ageusia MetaADEDB
Alanine Aminotransferase Increased SIDER
Angioedema ADReCS
Anhedonia MetaADEDB
Anorgasmia MetaADEDB
Aptyalism MetaADEDB
Arthralgia ADReCS
Arthritis Rheumatoid MetaADEDB
Aspartate Aminotransferase Increased SIDER
Asthenia ADReCS
Atrioventricular Block First Degree MetaADEDB
Attempted Suicide MetaADEDB
Autoimmune Hepatitis MetaADEDB
Avascular Necrosis MetaADEDB
Back Ache MetaADEDB
Back Pain ADReCS
Bacterial Test Positive MetaADEDB
Basophil Percentage Increased MetaADEDB
Benign Prostatic Hyperplasia ADReCS
Benign Prostatic Hypertrophy SIDER
Bladder Catheter Temporary MetaADEDB
Bladder Catheterisation MetaADEDB
Bladder Pain ADReCS
Bleeding Vaginal MetaADEDB
Blindness ADReCS
Blood Alkaline Phosphatase MetaADEDB
Blood Urine Present MetaADEDB
Blurred Vision MetaADEDB
Bone Spur MetaADEDB
Bradypnoea MetaADEDB
Brain Hypoxia MetaADEDB
Breakthrough Bleeding MetaADEDB
Breast Tenderness MetaADEDB
Bronchitis ADReCS
Bruise MetaADEDB
Burn Oesophageal MetaADEDB
Bursitis MetaADEDB
Buttock Pain MetaADEDB
Cancer MetaADEDB
Candida Infection MetaADEDB
Cardiac Decompensation MetaADEDB
Cardiac Murmur MetaADEDB
Cardiac Output Decreased MetaADEDB
Cerebral Ischaemia MetaADEDB
Cerebrovascular Accident ADReCS
Cervical Myelopathy MetaADEDB
Chapped Lips MetaADEDB
Chill MetaADEDB
Cholecystectomies MetaADEDB
Cholecystitis Acute MetaADEDB
Cholecystitis Infective MetaADEDB
Cholesterol Granuloma MetaADEDB
Coagulation Test Abnormal MetaADEDB
Cold Extremities MetaADEDB
Colitis Ischaemic MetaADEDB
Colonic Polyp MetaADEDB
Colostomy MetaADEDB
Completed Suicide MetaADEDB
Complex Partial Seizures MetaADEDB
Concomitant Disease Aggravated MetaADEDB
Confusional State ADReCS
Conjunctival Deposit MetaADEDB
Constipated MetaADEDB
Constipation ADReCS
Constipation Chronic SIDER
Corneal Ulcer MetaADEDB
Cough ADReCS
Cough Increased ADReCS
Cystitis Radiation MetaADEDB
Cysto MetaADEDB
Cystocele MetaADEDB
Deglutition Disorder MetaADEDB
Dependence MetaADEDB
Depressed Mood PROTECT
Dermatitis ADReCS
Dermatosis MetaADEDB
Detrusor Hyperreflexia SIDER
Diabetes Mellitus Inadequate Control MetaADEDB
Diabetes Mellitus Non-Insulin-Dependent MetaADEDB
Diarrhoea ADReCS
Difficult To Wean From Ventilator MetaADEDB
Disease Complication MetaADEDB
Disorder Retinal MetaADEDB
Disturbance In Attention MetaADEDB
Dizziness ADReCS
Drowsiness MetaADEDB
Drug Administered At Inappropriate Site MetaADEDB
Drug Administration Error MetaADEDB
Drug Ineffective MetaADEDB
Drug Withdrawal Headache MetaADEDB
Dry Eye ADReCS
Dry Mouth ADReCS
Dry Skin ADReCS
Dry Throat MetaADEDB
Dysgeusia ADReCS
Dyspepsia ADReCS
Dyspnoea PROTECT
Dysuria MetaADEDB
Early Morning Awakening MetaADEDB
Eating Disorder MetaADEDB
Economic Problem MetaADEDB
Effusion MetaADEDB
Emotional Disorder MetaADEDB
Emotional Distress MetaADEDB
Encephalitis MetaADEDB
Endotracheal Intubation Complication MetaADEDB
Enterococcal Sepsis MetaADEDB
Enuresis MetaADEDB
Erectile Dysfunction ADReCS
Eruption MetaADEDB
Excessive Sleepiness MetaADEDB
Excessive Thirst MetaADEDB
Eye Pain MetaADEDB
Eye Pruritus MetaADEDB
Face Oedema ADReCS
Faecal Disimpaction MetaADEDB
Family Stress MetaADEDB
Fat Tissue Increased MetaADEDB
Fatigue MetaADEDB
Feeling Abnormal ADReCS
Feeling Guilty MetaADEDB
Flatulence ADReCS
Fracture Treatment MetaADEDB
Frustration MetaADEDB
Gallbladder Cholesterolosis MetaADEDB
Gastrointestinal Pain ADReCS
Gastrointestinal Surgery MetaADEDB
Hair Texture Abnormal MetaADEDB
Hallucination ADReCS
Head Injury MetaADEDB
Headache ADReCS
Heart Rate Abnormal MetaADEDB
Helicobacter Gastritis MetaADEDB
Hepatic Congestion MetaADEDB
Herpes Zoster MetaADEDB
Hyperhidrosis ADReCS
Hyperkeratosis MetaADEDB
Hyperreflexia ADReCS
Hypersensitivity ADReCS
Hypertension ADReCS
Hypertonia MetaADEDB
Hypertonic Bladder ADReCS
Hypertrophy ADReCS
Hypothyroid MetaADEDB
Immune Reconstitution Syndrome MetaADEDB
Impaired Driving Ability MetaADEDB
Impaired Gastric Emptying MetaADEDB
Increased Appetite MetaADEDB
Infection Upper Respiratory MetaADEDB
Infection Urinary Tract MetaADEDB
Influenza ADReCS
Injection Site Dermatitis MetaADEDB
Injury PROTECT
Insomnia ADReCS
Intestinal Functional Disorder ADReCS
Intubation MetaADEDB
Irritability ADReCS
Irritable Bowel Syndrome ADReCS
Itch MetaADEDB
Lacrimation Increased MetaADEDB
Left Atrial Dilatation MetaADEDB
Ligament Sprain MetaADEDB
Lip Disorder MetaADEDB
Lip Dry MetaADEDB
Lip Exfoliation MetaADEDB
Lung Infection MetaADEDB
Malignant Hypertension MetaADEDB
Mass Excision MetaADEDB
Mean Cell Haemoglobin Increased MetaADEDB
Meniscus Lesion MetaADEDB
Mental Disability ADReCS
Mental Status Changes MetaADEDB
Micturition Urgency MetaADEDB
Migraine With Aura MetaADEDB
Mitral Valve Prolapse MetaADEDB
Mood Altered PROTECT
Mouth Ulceration ADReCS
Multifocal Leukoencephalopathy MetaADEDB
Multiple Injuries MetaADEDB
Multiple Sclerosis MetaADEDB
Multiple Sclerosis Relapse MetaADEDB
Muscle Injury MetaADEDB
Musculoskeletal Discomfort ADReCS
Musculoskeletal Pain MetaADEDB
Mutism MetaADEDB
Mycosis Fungoides MetaADEDB
Nasal Dryness PROTECT
Nasal Sinus Congestion MetaADEDB
Nasopharyngitis MetaADEDB
Nausea ADReCS
Negative Thoughts MetaADEDB
Neuralgia MetaADEDB
Neuropathy Peripheral MetaADEDB
Obstructive Airways Disorder ADReCS
Oedema ADReCS
Oedema Peripheral ADReCS
Oncologic Complication MetaADEDB
Optic Ischaemic Neuropathy MetaADEDB
Oral Disorder MetaADEDB
Pain ADReCS
Palpitations ADReCS
Paraesthesia Oral MetaADEDB
Periorbital Haematoma MetaADEDB
Peripheral Sensorimotor Neuropathy MetaADEDB
Pharyngitis ADReCS
Pharyngolaryngeal Pain MetaADEDB
Pitting Oedema MetaADEDB
Platelet Aggregation MetaADEDB
Pollakiuria MetaADEDB
Post Herpetic Neuralgia MetaADEDB
Productive Cough MetaADEDB
Prostatic Hypertrophy SIDER
Pruritus ADReCS
Pulmonary Hypertension MetaADEDB
Pulmonary Infarction MetaADEDB
Quadriparesis MetaADEDB
Rash ADReCS
Reading Disorder MetaADEDB
Respiratory Rate Increased MetaADEDB
Respiratory Tract Infection ADReCS
Retinal Artery Thrombosis MetaADEDB
Rhinitis ADReCS
Right Heart Failure MetaADEDB
Secretion Discharge MetaADEDB
Sepsis Syndrome MetaADEDB
Sinusitis ADReCS
Skeletal Injury MetaADEDB
Skin Lesion MetaADEDB
Sleep Talking MetaADEDB
Sleep Walking MetaADEDB
Social Avoidant Behaviour MetaADEDB
Social Problem MetaADEDB
Somnolence ADReCS
Sputum Discoloured MetaADEDB
Stomatitis ADReCS
Stool Analysis Abnormal MetaADEDB
Stress MetaADEDB
Stress Incontinence MetaADEDB
Sudden Onset Of Sleep MetaADEDB
Sweating SIDER
Swollen Tongue MetaADEDB
Tachycardia ADReCS
Tardive Dyskinesia MetaADEDB
Tendinitis MetaADEDB
Tendon Injury MetaADEDB
Terminal State MetaADEDB
Therapeutic Response Unexpected MetaADEDB
Therapy Responder MetaADEDB
Thinking Abnormal ADReCS
Throat Tightness MetaADEDB
Tobacco User MetaADEDB
Trichorrhexis MetaADEDB
Troponin Increased MetaADEDB
Ulcer ADReCS
Ulcerative Stomatitis SIDER
Unresponsive To Stimuli MetaADEDB
Urethral Disorder SIDER
Urge Incontinence MetaADEDB
Urinary Retention ADReCS
Urinary Tract Disorder ADReCS
Urinary Tract Infection ADReCS
Urinary Tract Infection Enterococcal MetaADEDB
Vaginal Burning Sensation MetaADEDB
Vaginal Infection ADReCS
Vaginal Inflammation ADReCS
Vascular Resistance Systemic Increased MetaADEDB
Viral Upper Respiratory Tract Infection MetaADEDB
Vision Blurred PROTECT
Visual Acuity Reduced ADReCS
Visual Impairment ADReCS
Vitamin B 12 Deficiency MetaADEDB
Vomiting ADReCS
Weight Decreased ADReCS
Weight Increased ADReCS

InAADR: Drug-Protein-ADRs database