InAADR

Drug Information

Drug Name: Clofarabine (123318-82-1)
PubChem ID: 119182
SMILES: C1=NC2=C(N1[C@H]3[C@H]([C@@H]([C@H](O3)CO)O)F)N=C(N=C2N)Cl
InchiKey: WDDPHFBMKLOVOX-AYQXTPAHSA-N
Therapeutic Category: Antimetabolites, Antineoplastic Agents, Noxae

Computed Drug Properties

Molecular Weight (dalton): 303.681
LogP: -0.3494
Ring Count: 2
Hydrogen Bond Acceptor Count: 8
Hydrogen Bond Donor Count: 3
Total Polar Surface Area: 119.31

This panel provides information on interacting drugs and their ADRs along with references

Interacting drug Toxicity Interaction Type Mechanism Reference

This panel provides drug-protein interaction and their ADRs along with references

Toxicity Interacting Protein Mechanism Reference

This panel provides drug-food interactions and their ADRs along with references

Food Toxicity Reference

This panel provides information on metabolites and their ADRs along with references

Metabolite Toxicity Place of Metabolism Mechanism Reference

This panel provides information on drug category

Toxicity Source
Abdominal Compartment Syndrome MetaADEDB
Abdominal Pain ADReCS
Abdominal Pain ADReCS
Abdominal Tenderness MetaADEDB
Abnormal Dreams MetaADEDB
Abnormal Lfts MetaADEDB
Acid Reflux MetaADEDB
Acidosis MetaADEDB
Activities Of Daily Living Impaired MetaADEDB
Acute Graft Versus Host Disease MetaADEDB
Acute Graft Versus Host Disease In Intestine MetaADEDB
Acute Graft Versus Host Disease In Liver MetaADEDB
Acute Kidney Failure MetaADEDB
Acute Leukaemia SIDER
Acute Myeloid Leukaemia SIDER
Acute Myeloid Leukaemia Recurrent MetaADEDB
Acute Respiratory Failure MetaADEDB
Adenopathy MetaADEDB
Adrenal Insufficiency MetaADEDB
Adrenal Neoplasm MetaADEDB
Adynamic Ileus MetaADEDB
Afib MetaADEDB
Agitated MetaADEDB
Agitation ADReCS
Alanine Aminotransferase Increased ADReCS
Alkalosis Hypochloraemic MetaADEDB
Allergic Dermatitis MetaADEDB
Alopecia PROTECT
Alpha Haemolytic Streptococcal Infection MetaADEDB
Amylase Increased PROTECT
Anaemia ADReCS
Anal Abscess MetaADEDB
Anal Fistula MetaADEDB
Androgen Deficiency MetaADEDB
Anemia Aplastic MetaADEDB
Angiitis MetaADEDB
Angiopathy ADReCS
Anorexia ADReCS
Anticonvulsant Drug Level Decreased MetaADEDB
Anuria MetaADEDB
Anxiety ADReCS
Aortic Aneurysm SIDER
Aortic Dissection SIDER
Aortic Thrombosis MetaADEDB
Aortic Valve Sclerosis MetaADEDB
Arrhythmia MetaADEDB
Arterial Pressure Nos Decreased MetaADEDB
Arthralgia ADReCS
Ascites MetaADEDB
Aspartate Aminotransferase Increase MetaADEDB
Aspartate Aminotransferase Increased ADReCS
Aspergillosis MetaADEDB
Aspiration Pneumonia MetaADEDB
Asthenia ADReCS
Asystole MetaADEDB
Atelectasis MetaADEDB
Atrial Tachycardia MetaADEDB
Aura MetaADEDB
Axonal Neuropathy MetaADEDB
Back Pain ADReCS
Bacteraemia ADReCS
Bacteria Sputum Identified MetaADEDB
Bacteria Stool Identified MetaADEDB
Bacterial Infection ADReCS
Bacterial Sepsis MetaADEDB
Bacterial Test Positive MetaADEDB
Bacterial Toxaemia MetaADEDB
Bile Duct Obstruction MetaADEDB
Biliary Dilatation MetaADEDB
Bilirubin Conjugated Increased MetaADEDB
Blast Cell Count Decreased MetaADEDB
Bleb MetaADEDB
Bleeding Hemorrhoids MetaADEDB
Blood Amylase Increased MetaADEDB
Blood Bilirubin Increased ADReCS
Blood Creatinine Increased ADReCS
Blood Culture Positive MetaADEDB
Blood Electrolytes Decreased MetaADEDB
Blood Phosphorus Decreased MetaADEDB
Blood Potassium Decreased MetaADEDB
Blood Potassium Increased MetaADEDB
Blood Pressure Systolic Decreased MetaADEDB
Blood Test Abnormal MetaADEDB
Blood Urea MetaADEDB
Blood Uric Acid MetaADEDB
Blood Uric Acid Increased ADReCS
Body Temperature Increased ADReCS
Bone Disorder ADReCS
Bone Marrow Depression MetaADEDB
Bone Marrow Failure ADReCS
Bone Pain ADReCS
Bowel Sounds Abnormal MetaADEDB
Bradycardia MetaADEDB
Brain Scan Abnormal MetaADEDB
Breath Sounds Abnormal MetaADEDB
Bronchial Wall Thickening MetaADEDB
Bronchiectasis MetaADEDB
Burn Oesophageal MetaADEDB
Burning Sensation MetaADEDB
Caecitis ADReCS
Candida Infection MetaADEDB
Candidiasis ADReCS
Capillary Leak Syndrome ADReCS
Cardiac Decompensation MetaADEDB
Cardiac Disorder ADReCS
Cardiac Enlargement MetaADEDB
Cardio-Respiratory Arrest MetaADEDB
Cardioactive Drug Level MetaADEDB
Carotid Artery Occlusion MetaADEDB
Catatonia MetaADEDB
Catheter Site Cellulitis MetaADEDB
Catheter Site Discharge MetaADEDB
Catheter Site Erythema MetaADEDB
Catheter Site Infection MetaADEDB
Catheter Site Necrosis MetaADEDB
Cell Death ADReCS
Cellulitis ADReCS
Cellulitis Gangrenous MetaADEDB
Central Nervous System Infection MetaADEDB
Central Nervous System Lesion MetaADEDB
Cerebral Ischaemia MetaADEDB
Chest Infection MetaADEDB
Chest Pain MetaADEDB
Chills ADReCS
Chloroma MetaADEDB
Choking Sensation MetaADEDB
Cholangiolitis MetaADEDB
Cholecystitis MetaADEDB
Cholecystitis Acute PROTECT
Cholelithiasis PROTECT
Clostridial Infection MetaADEDB
Clostridium Colitis ADReCS
Clostridium Difficile Colitis PROTECT
Clostridium Difficile Toxin Test Positive MetaADEDB
Colitis MetaADEDB
Computerised Tomogram MetaADEDB
Confabulation MetaADEDB
Congenital Mitral Valve Incompetence MetaADEDB
Congenital Tracheomalacia MetaADEDB
Congenital Tricuspid Valve Incompetence MetaADEDB
Conjunctival Deposit MetaADEDB
Constipation ADReCS
Contusion PROTECT
Corona Virus Infection MetaADEDB
Corynebacterium Infection MetaADEDB
Cough ADReCS
Creatinine Increased SIDER
Csf Protein MetaADEDB
Culture Positive MetaADEDB
Culture Stool Positive MetaADEDB
Cutaneous Mycosis MetaADEDB
Cytokine Storm MetaADEDB
Cytolysis ADReCS
Dacrocystitis MetaADEDB
Death ADReCS
Decerebration MetaADEDB
Decreased Appetite ADReCS
Dehydration PROTECT
Depressed Level Of Consciousness MetaADEDB
Dermatitis ADReCS
Dermatitis Bullous MetaADEDB
Dermatosis MetaADEDB
Device Related Infection ADReCS
Dialysis MetaADEDB
Diarrhea MetaADEDB
Diarrhoea ADReCS
Dilatation Ventricular MetaADEDB
Discomfort ADReCS
Disease Progression MetaADEDB
Diverticular Perforation MetaADEDB
Dizziness ADReCS
Dizziness Exertional MetaADEDB
Drug Withdrawal Headache MetaADEDB
Dry Skin ADReCS
Dyspnoea ADReCS
Ear Ache MetaADEDB
Edema Extremities MetaADEDB
Effusion ADReCS
Electrocardiogram Pr Shortened MetaADEDB
Electrocardiogram Qrs Complex Abnormal MetaADEDB
Electrocardiogram T Wave Abnormal MetaADEDB
Electrocardiogram T Wave Amplitude Decreased MetaADEDB
Electrolyte Disorder MetaADEDB
Electromechanical Dissociation MetaADEDB
Emesis MetaADEDB
Encephalitis MetaADEDB
Enterobacter Bacteraemia MetaADEDB
Enterobacter Sepsis MetaADEDB
Enterococcal Bacteraemia ADReCS
Enterococcal Infection MetaADEDB
Enterococcal Sepsis MetaADEDB
Enterocolitis PROTECT
Enterocolitis Infectious MetaADEDB
Epidermolysis MetaADEDB
Epiglottitis MetaADEDB
Epistaxis ADReCS
Epstein-Barr Virus Test Positive MetaADEDB
Eruption MetaADEDB
Erythema ADReCS
Erythema Multiforme MetaADEDB
Escherichia Bacteraemia ADReCS
Escherichia Infection MetaADEDB
Escherichia Sepsis ADReCS
Excoriation MetaADEDB
Extremity Pain MetaADEDB
Eye Infection Toxoplasmal MetaADEDB
Facial Bones Fracture MetaADEDB
Fatigue ADReCS
Febrile Neutropenia ADReCS
Feeling Abnormal ADReCS
Feeling Hot PROTECT
Fluid Imbalance MetaADEDB
Fluid Overload MetaADEDB
Flushing ADReCS
Fungal Infection ADReCS
Fungal Rash MetaADEDB
Fungal Sepsis ADReCS
Fungus Serology Test Positive MetaADEDB
Gastroenteritis Adenovirus ADReCS
Gastrointestinal Disorder SIDER
Gastrointestinal Fungal Infection MetaADEDB
Gastrointestinal Oedema MetaADEDB
Gastrointestinal Pain ADReCS
Gastrointestinal Ulcer MetaADEDB
General Physical Health Deterioration MetaADEDB
Generalised Erythema PROTECT
Gingival Bleeding ADReCS
Haemangioma MetaADEDB
Haemangioma Of Liver MetaADEDB
Haematemesis PROTECT
Haematoma PROTECT
Haematotoxicity MetaADEDB
Haematuria ADReCS
Haemodialysis MetaADEDB
Haemoglobin ADReCS
Haemorrhage ADReCS
Haemorrhage Intracranial MetaADEDB
Haemorrhage Rectum MetaADEDB
Haemorrhagic Hepatic Cyst MetaADEDB
Haemosiderosis MetaADEDB
Hallucinations Mixed MetaADEDB
Headache ADReCS
Heart Rate Increased MetaADEDB
Hepatic Infection Fungal MetaADEDB
Hepatitis B Core Antigen Positive MetaADEDB
Hepatitis B Positive MetaADEDB
Hepatobiliary Disease ADReCS
Hepatocellular Injury PROTECT
Hepatomegaly ADReCS
Hepatorenal Failure MetaADEDB
Hepatosplenomegaly MetaADEDB
Hepatotoxicity ADReCS
Herpes Nos SIDER
Herpes Ophthalmic MetaADEDB
Herpes Simplex ADReCS
Herpes Virus Infection ADReCS
Herpes Zoster ADReCS
High Blood Pressure MetaADEDB
Hyperbilirubinaemia ADReCS
Hypercapnia MetaADEDB
Hypercoagulation MetaADEDB
Hyperhidrosis PROTECT
Hypermagnesaemia MetaADEDB
Hypersensitivity PROTECT
Hypertension ADReCS
Hyperuricaemia ADReCS
Hypoacusis PROTECT
Hypokalaemia MetaADEDB
Hypophosphataemia MetaADEDB
Hypoproteinaemia MetaADEDB
Hypotension ADReCS
Hypotension Orthostatic MetaADEDB
Hypoxia MetaADEDB
Ill-Defined Disorder ADReCS
Infection ADReCS
Infection Upper Respiratory MetaADEDB
Infestation SIDER
Infestation Nos SIDER
Inflammation ADReCS
Influenza ADReCS
Injection Site Pain ADReCS
Irritability ADReCS
Ischaemia MetaADEDB
Jaundice ADReCS
Kidney Enlargement MetaADEDB
Kidney Failure MetaADEDB
Klebsiella Infection MetaADEDB
Klebsiella Sepsis MetaADEDB
Laceration MetaADEDB
Left Ventricular Dysfunction ADReCS
Left Ventricular Systolic Dysfunction SIDER
Lethargy ADReCS
Leucopenia MetaADEDB
Leukaemic Infiltration Hepatic MetaADEDB
Leukopenia ADReCS
Leukopenia Neonatal MetaADEDB
Lip Dry MetaADEDB
Lipase MetaADEDB
Lipase Increased PROTECT
Liver Scan Abnormal MetaADEDB
Lower Respiratory Tract Infection Fungal MetaADEDB
Lung Consolidation MetaADEDB
Lung Edema MetaADEDB
Lung Infection MetaADEDB
Lung Infiltration MetaADEDB
Lymphadenopathy Mediastinal MetaADEDB
Lymphocytes Decreased MetaADEDB
Lymphopenia ADReCS
Malaise ADReCS
Mastoid Disorder MetaADEDB
Mediastinal Disorder SIDER
Medical Device Complication MetaADEDB
Mental Disorder SIDER
Mental Status Changes ADReCS
Metabolic Encephalopathy MetaADEDB
Microangiopathic Haemolytic Anaemia MetaADEDB
Mouth Bleeding MetaADEDB
Mouth Haemorrhage ADReCS
Mouth Ulceration PROTECT
Mucosal Inflammation ADReCS
Multi-Organ Failure ADReCS
Muscle Disorder MetaADEDB
Musculoskeletal Chest Pain PROTECT
Musculoskeletal Discomfort ADReCS
Myalgia ADReCS
Myelodysplastic Syndrome Transformation MetaADEDB
Nasogastric Output High MetaADEDB
Nausea ADReCS
Neck Mass MetaADEDB
Neck Pain PROTECT
Necrolysis Epidermal SIDER
Neoplasm ADReCS
Nephropathy Toxic ADReCS
Nephrotic Syndrome MetaADEDB
Nervous System Disorder SIDER
Neumonia MetaADEDB
Neuropathy Peripheral PROTECT
Neutropenia ADReCS
Neutropenic Colitis PROTECT
Neutropenic Infection MetaADEDB
Neutropenic Sepsis MetaADEDB
Neutrophil Count Abnormal MetaADEDB
Nocardiosis MetaADEDB
Nodule Skin MetaADEDB
Non-Hodgkin Lymphoma MetaADEDB
Obliterative Bronchiolitis MetaADEDB
Obstruction MetaADEDB
Obstructive Airways Disorder MetaADEDB
Occult Blood Positive MetaADEDB
Ocular Toxicity MetaADEDB
Oedema ADReCS
Oedema Peripheral PROTECT
Opportunistic Infection MetaADEDB
Optic Nerve Sheath Haemorrhage MetaADEDB
Optic Neuritis MetaADEDB
Oral Candidiasis ADReCS
Oropharyngeal Discomfort ADReCS
Oropharyngeal Pain ADReCS
Pain ADReCS
Pain In Extremity ADReCS
Palmar-Plantar Erythrodysaesthesia Syndrome ADReCS
Pancreatitis ADReCS
Paraesthesia PROTECT
Parainfluenzae Virus Infection ADReCS
Paranoia MetaADEDB
Paraparesis MetaADEDB
Pathogen Resistance MetaADEDB
Pedal Pulse Absent MetaADEDB
Pedal Pulse Decreased MetaADEDB
Pericardial Effusion ADReCS
Pericardial Rub MetaADEDB
Pericarditis PROTECT
Peripheral Ischaemia MetaADEDB
Peripheral Sensory Neuropathy MetaADEDB
Peritoneal Effusion MetaADEDB
Petechiae ADReCS
Platelet Count Abnormal MetaADEDB
Pleural Calcification MetaADEDB
Pleural Disorder ADReCS
Pleural Effusion ADReCS
Pneumatosis MetaADEDB
Pneumonia ADReCS
Pneumonia Adenoviral MetaADEDB
Pneumonia Fungal ADReCS
Pneumonia Klebsiella MetaADEDB
Pneumonia Primary Atypical ADReCS
Pneumothorax Spontaneous Tension MetaADEDB
Portal Hypertension MetaADEDB
Proctalgia ADReCS
Pruritus ADReCS
Pseudomonal Sepsis MetaADEDB
Psychoses MetaADEDB
Pulmonary Congestion MetaADEDB
Pulmonary Function Test Decreased MetaADEDB
Pulmonary Hypertension MetaADEDB
Pulmonary Oedema ADReCS
Pulmonary Veno-Occlusive Disease MetaADEDB
Pyrexia ADReCS
Rash ADReCS
Rash Erythematous PROTECT
Rash Generalised PROTECT
Rash Maculo-Papular PROTECT
Rash Pruritic ADReCS
Rectal Fissure MetaADEDB
Refusal Of Treatment By Relative MetaADEDB
Renal Failure Acute ADReCS
Renal Impairment MetaADEDB
Renal Tubular Necrosis MetaADEDB
Respiratory Disorder MetaADEDB
Respiratory Distress ADReCS
Respiratory Failure MetaADEDB
Respiratory Syncytial Virus Infection ADReCS
Restlessness PROTECT
Retinal Bleeding MetaADEDB
Retrograde Portal Vein Flow MetaADEDB
Rhabdomyosarcoma MetaADEDB
Rigors SIDER
Scar MetaADEDB
Sensation Of Foreign Body MetaADEDB
Sepsis ADReCS
Sepsis Syndrome MetaADEDB
Septic Shock ADReCS
Sickness SIDER
Sinusitis ADReCS
Skin Desquamation MetaADEDB
Skin Exfoliation PROTECT
Skin Hyperpigmentation PROTECT
Skin Lesion MetaADEDB
Skin Oedema MetaADEDB
Small Intestinal Obstruction MetaADEDB
Soft Tissue Necrosis MetaADEDB
Somnolence ADReCS
Spleen Disorder MetaADEDB
Splenic Infection MetaADEDB
Splenic Lesion MetaADEDB
Staphylococcal Bacteraemia ADReCS
Staphylococcal Infection ADReCS
Staphylococcal Sepsis ADReCS
Stevens-Johnson Syndrome ADReCS
Stomatitis ADReCS
Streptococcal Bacteraemia MetaADEDB
Stridor MetaADEDB
Sudden Death MetaADEDB
Supraventricular Tachycardia MetaADEDB
Systemic Inflammatory Response Syndrome ADReCS
T-Cell Lymphoma MetaADEDB
Tachycardia ADReCS
Tachypnoea ADReCS
Tenderness ADReCS
Therapy Non-Responder MetaADEDB
Throat Sore SIDER
Thrombocytopenia ADReCS
Tonic Clonic Movements MetaADEDB
Toxic Encephalopathy MetaADEDB
Toxic Epidermal Necrolysis ADReCS
Transaminases Increased MetaADEDB
Transfusion Reaction ADReCS
Tremor ADReCS
Tumour Lysis Syndrome ADReCS
Ultrasound Kidney MetaADEDB
Unresponsive To Stimuli MetaADEDB
Unresponsive To Verbal Stimuli MetaADEDB
Upper Respiratory Tract Infection ADReCS
Urethral Disorder SIDER
Urinary Tract Disorder SIDER
Urinary Tract Infection Pseudomonal MetaADEDB
Urosepsis MetaADEDB
Vaginal Cellulitis MetaADEDB
Vaginal Lesion MetaADEDB
Vein Discolouration MetaADEDB
Venoocclusive Disease ADReCS
Venous Pressure Jugular Increased MetaADEDB
Vertigo ADReCS
Virus Urine Test Positive MetaADEDB
Vomiting ADReCS
Weight Decreased ADReCS
Wheeze MetaADEDB
White Blood Cell Disorder MetaADEDB

InAADR: Drug-Protein-ADRs database