InAADR

Drug Information

Drug Name: Chlorambucil (305-03-3)
PubChem ID: 2708
SMILES: C1=CC(=CC=C1CCCC(=O)O)N(CCCl)CCCl
InchiKey: JCKYGMPEJWAADB-UHFFFAOYSA-N
Therapeutic Category: Alkylating Agents, Antineoplastic Agents, Noxae

Computed Drug Properties

Molecular Weight (dalton): 304.217
LogP: 3.3779
Ring Count: 1
Hydrogen Bond Acceptor Count: 2
Hydrogen Bond Donor Count: 1
Total Polar Surface Area: 40.54

This panel provides information on interacting drugs and their ADRs along with references

Interacting drug Toxicity Interaction Type Mechanism Reference
Prednisone (53-03-2) Generalised Tonic-Clonic Seizure Additives The seizures in this patient may have been due to the additive effects of both drugs Chlorambucil/prednisone-induced seizures in a patient with non-Hodgkin's lymphoma

This panel provides drug-protein interaction and their ADRs along with references

Toxicity Interacting Protein Mechanism Reference

This panel provides drug-food interactions and their ADRs along with references

Food Toxicity Reference

This panel provides information on metabolites and their ADRs along with references

Metabolite Toxicity Place of Metabolism Mechanism Reference

This panel provides information on drug category

Toxicity Source
Abdominal Pain ADReCS
Abnormal Gait MetaADEDB
Abnormal Movements MetaADEDB
Abnormalities Drug-Induced MetaADEDB
Abscess Bacterial MetaADEDB
Acute Kidney Injury MetaADEDB
Acute Leukaemia MetaADEDB
Acute Myeloblastic Leukemia MetaADEDB
Acute Myelomonocytic Leukaemia MetaADEDB
Adenocarcinoma MetaADEDB
Aggression ADReCS
Agitated MetaADEDB
Agitation ADReCS
Agraphia MetaADEDB
Alopecia ADReCS
Amenorrhea MetaADEDB
Amenorrhoea ADReCS
Anaemia ADReCS
Anemia Hemolytic MetaADEDB
Anemia Megaloblastic MetaADEDB
Angioedema ADReCS
Anhidrosis MetaADEDB
Anorexia ADReCS
Aortic Arteriosclerosis MetaADEDB
Aplasia Pure Red Cell MetaADEDB
Apoplexy MetaADEDB
Apoptosis MetaADEDB
Arteriosclerosis MetaADEDB
Arthritis Rheumatoid MetaADEDB
Assisted Fertilisation ADReCS
Asthenia ADReCS
Ataxia ADReCS
Atrophy ADReCS
Aura MetaADEDB
Autoimmune Neutropenia MetaADEDB
Autoimmune Thrombocytopenia MetaADEDB
Bacterial Infection MetaADEDB
Behcet Syndrome MetaADEDB
Bladder Pain ADReCS
Blepharospasm MetaADEDB
Blindness Cortical MetaADEDB
Blood Brain Barrier Defect MetaADEDB
Blood Uric Acid Increased ADReCS
Blurred Vision MetaADEDB
Body Dysmorphic Disorder MetaADEDB
Body Temperature Increased ADReCS
Bone Marrow Depression SIDER
Bone Marrow Diseases MetaADEDB
Bone Marrow Disorder MetaADEDB
Bone Marrow Failure ADReCS
Bone Marrow Failure Syndromes MetaADEDB
Bradycardia MetaADEDB
Breakthrough Bleeding MetaADEDB
Bronchial Neoplasms MetaADEDB
Bronchitis MetaADEDB
Bronchitis MetaADEDB
Bronchopneumonia MetaADEDB
Burning Sensation Mucosal MetaADEDB
Cancer MetaADEDB
Candida Infection MetaADEDB
Carcinoma MetaADEDB
Carcinoma Squamous Cell MetaADEDB
Carcinoma Transitional Cell MetaADEDB
Cardiac Murmur MetaADEDB
Cardiomyopathy MetaADEDB
Carotid Artery Stenosis MetaADEDB
Cartilage Development Disorder MetaADEDB
Cataract MetaADEDB
Cell Death ADReCS
Cell Marker Increased MetaADEDB
Cell Transformation Neoplastic MetaADEDB
Central Nervous System Diseases MetaADEDB
Cerebellar Atrophy MetaADEDB
Cerebral Calcification MetaADEDB
Cerebral Toxoplasmosis MetaADEDB
Cholangiolitis MetaADEDB
Cholestasis MetaADEDB
Chromosome Abnormality MetaADEDB
Circumstance Or Information Capable Of Leading To Medication Error MetaADEDB
Citrobacter Sepsis MetaADEDB
Confabulation MetaADEDB
Confusional State ADReCS
Contraindication To Medical Treatment MetaADEDB
Convulsion ADReCS
Convulsions Generalised SIDER
Convulsions Grand Mal MetaADEDB
Coombs Indirect Test Positive MetaADEDB
Cough ADReCS
Cutaneous Hypersensitivity SIDER
Cystitis ADReCS
Cystitis Noninfective ADReCS
Cytolysis ADReCS
Decreased Appetite ADReCS
Deep Vein Thromboses MetaADEDB
Demyelination MetaADEDB
Dermatitis ADReCS
Dermatitis Atopic ADReCS
Diabetes MetaADEDB
Diarrhoea ADReCS
Diffuse Large B-Cell Lymphoma MetaADEDB
Disease Of Liver MetaADEDB
Disease Progression ADReCS
Disorder Lung MetaADEDB
Disorder Renal MetaADEDB
Drug Eruptions MetaADEDB
Drug Exposure During Pregnancy MetaADEDB
Drug Fever ADReCS
Drug Hypersensitivity MetaADEDB
Drug Toxicity MetaADEDB
Drug-Induced Liver Injury MetaADEDB
Dyspnoea ADReCS
Dyspnoea Exacerbated MetaADEDB
Elevated Erythrocyte Sedimentation Rate MetaADEDB
Embolic Stroke MetaADEDB
Emphysema MetaADEDB
Encephalitis MetaADEDB
Endocarditis Candida MetaADEDB
Enlarged Liver MetaADEDB
Enlarged Spleen MetaADEDB
Eosinophilia MetaADEDB
Epilepsies Myoclonic MetaADEDB
Epilepsies Partial MetaADEDB
Epilepsy Tonic-Clonic MetaADEDB
Erythema ADReCS
Erythema Infectiosum MetaADEDB
Erythema Multiforme ADReCS
Exanthema MetaADEDB
Eye Swelling MetaADEDB
Facial Dysmorphism MetaADEDB
Fatigue ADReCS
Febrile Neutropenia ADReCS
Feeling Abnormal ADReCS
Fertilization SIDER
Fetal Diseases MetaADEDB
Fever MetaADEDB
Fibrosis ADReCS
Gangrene MetaADEDB
Gastric Dilatation MetaADEDB
Gastroenteritis Radiation MetaADEDB
Gastrointestinal Pain ADReCS
General Physical Health Deterioration MetaADEDB
Generalised Erythema MetaADEDB
Giardiasis MetaADEDB
Glomerulonephritis Membranous MetaADEDB
Haemolysis MetaADEDB
Haemolytic Anaemia ADReCS
Haemorrhage Rectum MetaADEDB
Haemorrhagic Hepatic Cyst MetaADEDB
Hallucination ADReCS
Hallucinations MetaADEDB
Helicobacter Infection MetaADEDB
Hematologic Neoplasms MetaADEDB
Hematuria MetaADEDB
Hemiplegia MetaADEDB
Hepatotoxicity ADReCS
Hypersensitivity ADReCS
Hyperuricaemia ADReCS
Hypogammaglobulinaemia MetaADEDB
Hypovolaemia MetaADEDB
Hypoxia ADReCS
Immunosuppression ADReCS
Inappropriate Adh Syndrome MetaADEDB
Inappropriate Antidiuretic Hormone Secretion SIDER
Infection ADReCS
Infertility ADReCS
Inflammatory Bowel Disease MetaADEDB
Infusion Site Mobility Decreased MetaADEDB
Interstitial Lung Disease ADReCS
Interstitial Pneumonia SIDER
Intestinal Diseases MetaADEDB
Intracardiac Thrombus MetaADEDB
Jaundice ADReCS
Jc Virus Infection MetaADEDB
Kidney Diseases MetaADEDB
Kidney Infection MetaADEDB
Lacunar Infarction MetaADEDB
Leukaemia ADReCS
Leukemia MetaADEDB
Leukemia Lymphocytic Chronic B-Cell MetaADEDB
Leukoencephalopathy MetaADEDB
Leukopenia ADReCS
Lichenoid Keratosis MetaADEDB
Limb Deformity MetaADEDB
Liver Failure Acute MetaADEDB
Liver Neoplasms MetaADEDB
Low Set Ears MetaADEDB
Lower Limb Deformity MetaADEDB
Lower Respiratory Tract Infection Viral MetaADEDB
Lung Fibrosis Interstitial SIDER
Lung Neoplasms MetaADEDB
Lupus Erythematosus Systemic MetaADEDB
Lupus Nephritis MetaADEDB
Lymphadenopathy ADReCS
Lymphadenopathy Mediastinal MetaADEDB
Lymphatic Diseases MetaADEDB
Lymphoma MetaADEDB
Lymphoma Large B-Cell Diffuse MetaADEDB
Lymphoma Non-Hodgkin MetaADEDB
Lymphopenia ADReCS
Mammary Neoplasms Animal MetaADEDB
Meningoencephalitis MetaADEDB
Mental Disorder MetaADEDB
Metastatic Neoplasm ADReCS
Molluscum Contagiosum MetaADEDB
Mood Disorder Due To A General Medical Condition MetaADEDB
Mouth Ulceration ADReCS
Mucosal Inflammation ADReCS
Multi-Organ Failure MetaADEDB
Multifocal Leukoencephalopathy MetaADEDB
Muscle Twitching ADReCS
Muscle Weakness MetaADEDB
Myelodysplasia MetaADEDB
Myelopathy MetaADEDB
Myoclonus ADReCS
Nausea ADReCS
Necrolysis Epidermal SIDER
Neoplasm Malignant ADReCS
Neoplasm Recurrence MetaADEDB
Neoplasms Experimental MetaADEDB
Nephritic Syndrome MetaADEDB
Nephrosis Lipoid MetaADEDB
Nephrotic Syndrome MetaADEDB
Neumonia MetaADEDB
Neural Tube Defects MetaADEDB
Neuritis ADReCS
Neuropathy ADReCS
Neuropathy Peripheral ADReCS
Neutropenia ADReCS
Neutropenic Sepsis MetaADEDB
Obstruction ADReCS
Oculogyration MetaADEDB
Oedema ADReCS
Optic Atrophy ADReCS
Oral Infection MetaADEDB
Oral Torus MetaADEDB
Ovarian Cyst MetaADEDB
Ovarian Mass MetaADEDB
Pain ADReCS
Pancreatic Diseases MetaADEDB
Pancreatic Disorder SIDER
Pancytopenia ADReCS
Paralysis ADReCS
Paralysis Flaccid ADReCS
Paresis ADReCS
Peripheral Motor Neuropathy ADReCS
Peripheral Nervous System Diseases MetaADEDB
Peripheral Sensory Neuropathy ADReCS
Pharyngeal Disorder MetaADEDB
Pneumonia ADReCS
Pneumonia Fungal MetaADEDB
Pneumonia Mycoplasmal MetaADEDB
Premature Baby MetaADEDB
Premature Labour MetaADEDB
Pruritus ADReCS
Pseudomonal Sepsis MetaADEDB
Puberty ADReCS
Pulmonary Fibrosis ADReCS
Pulmonary Toxicity ADReCS
Pyelonephritis Chronic MetaADEDB
Rales ADReCS
Rash ADReCS
Relapsing Fever MetaADEDB
Renal Cyst MetaADEDB
Renal Failure ADReCS
Renal Failure Acute ADReCS
Renal Injury MetaADEDB
Respiratory Distress ADReCS
Respiratory Insufficiency MetaADEDB
Reticulocytopenia MetaADEDB
Retinitis Viral MetaADEDB
Rhesus Antibodies Positive MetaADEDB
Sarcoma Experimental MetaADEDB
Second Primary Malignancy SIDER
Seizures SIDER
Serum Sickness MetaADEDB
Sinus Disorder MetaADEDB
Skin Hyperpigmentation ADReCS
Skin Necrosis MetaADEDB
Social Avoidant Behaviour ADReCS
Speech Disorder MetaADEDB
Status Epilepticus MetaADEDB
Sterility SIDER
Stevens-Johnson Syndrome ADReCS
Stomatitis ADReCS
Streptococcal Infection MetaADEDB
Subacute Endocarditis MetaADEDB
Synovitis MetaADEDB
T-Cell Lymphoma MetaADEDB
Testicular Atrophy ADReCS
Testicular Diseases MetaADEDB
Thrombocytopenia ADReCS
Tooth Impacted MetaADEDB
Toxic Epidermal Necrolysis ADReCS
Treatment Related Secondary Malignancy ADReCS
Tremor ADReCS
Ulcer ADReCS
Ureteric Obstruction ADReCS
Uric Acid Level Increased SIDER
Urinary Bladder Neoplasms MetaADEDB
Urine Output ADReCS
Urticaria ADReCS
Vascular Calcification MetaADEDB
Vision Disorders MetaADEDB
Vitamin B 12 Deficiency MetaADEDB
Vomiting ADReCS
Waldenstrom Macroglobulinemia MetaADEDB
Walking Disability MetaADEDB
Withdrawn SIDER

InAADR: Drug-Protein-ADRs database