| Drug Name: | urokinase-type Plasminogen activator (uPA) (CASNA00115) |
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This panel provides information on interacting drugs and their ADRs along with references
| Interacting drug | Toxicity | Interaction Type | Mechanism | Reference |
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This panel provides drug-protein interaction and their ADRs along with references
| Toxicity | Interacting Protein | Mechanism | Reference |
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| Cellular Migration | Mitogen-activated protein kinase(ERK) (P28482) | uPA-induced ERK activation and stimulation of cellular migration [ ADR Type 2 ] | Myosin light chain kinase functions downstream of Ras/ERK to promote migration of urokinase-type plasminogen activator-stimulated cells in an integrin-selective manner |
| Diabetes Mellitus | Mitogen-activated protein kinase(ERK) (P28482) | Urban minority HIV-infected patients receiving combination antiretroviral therapy including a protease inhibitor may be at increased risk for the development of hyperglycemia and diabetes mellitus Risk factors for diabetes mellitus should be identified and blood glucose monitored in all patients receiving protease inhibitors [ ADR Type 2 ] | Myosin light chain kinase functions downstream of Ras/ERK to promote migration of urokinase-type plasminogen activator-stimulated cells in an integrin-selective manner |
| Hyperglycemia | Mitogen-activated protein kinase(ERK) (P28482) | Urban minority HIV-infected patients receiving combination antiretroviral therapy including a protease inhibitor may be at increased risk for the development of hyperglycemia and diabetes mellitus Risk factors for diabetes mellitus should be identified and blood glucose monitored in all patients receiving protease inhibitors [ ADR Type 2 ] | Myosin light chain kinase functions downstream of Ras/ERK to promote migration of urokinase-type plasminogen activator-stimulated cells in an integrin-selective manner |
This panel provides drug-food interactions and their ADRs along with references
| Food | Toxicity | Reference |
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This panel provides information on metabolites and their ADRs along with references
| Metabolite | Toxicity | Place of Metabolism | Mechanism | Reference |
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This panel provides information on drug category
| Toxicity | Source |
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